IL126071A - Process for the preparation of n-methyl-d-phenylalanyl-n [1-(3-[aminoiminomethyl) amino] propyl]-3, 3-difluoro-2-oxohexyl)-l-prolinamide - Google Patents

Process for the preparation of n-methyl-d-phenylalanyl-n [1-(3-[aminoiminomethyl) amino] propyl]-3, 3-difluoro-2-oxohexyl)-l-prolinamide

Info

Publication number
IL126071A
IL126071A IL12607197A IL12607197A IL126071A IL 126071 A IL126071 A IL 126071A IL 12607197 A IL12607197 A IL 12607197A IL 12607197 A IL12607197 A IL 12607197A IL 126071 A IL126071 A IL 126071A
Authority
IL
Israel
Prior art keywords
aminoiminomethyl
prolinamide
oxohexyl
phenylalanyl
difluoro
Prior art date
Application number
IL12607197A
Other versions
IL126071A0 (en
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of IL126071A0 publication Critical patent/IL126071A0/en
Publication of IL126071A publication Critical patent/IL126071A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12607197A 1996-03-26 1997-02-25 Process for the preparation of n-methyl-d-phenylalanyl-n [1-(3-[aminoiminomethyl) amino] propyl]-3, 3-difluoro-2-oxohexyl)-l-prolinamide IL126071A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62472196A 1996-03-26 1996-03-26
PCT/US1997/002869 WO1997035874A1 (en) 1996-03-26 1997-02-25 Process for the preparation of n-methyl-d-phenylalanyl-n-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-l-prolinamide

Publications (2)

Publication Number Publication Date
IL126071A0 IL126071A0 (en) 1999-05-09
IL126071A true IL126071A (en) 2003-06-24

Family

ID=24503070

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12607197A IL126071A (en) 1996-03-26 1997-02-25 Process for the preparation of n-methyl-d-phenylalanyl-n [1-(3-[aminoiminomethyl) amino] propyl]-3, 3-difluoro-2-oxohexyl)-l-prolinamide

Country Status (13)

Country Link
EP (1) EP1012165A1 (en)
JP (1) JP2000507267A (en)
KR (1) KR20000004991A (en)
CN (1) CN1121410C (en)
AR (1) AR006366A1 (en)
AU (1) AU710040B2 (en)
BR (1) BR9708369A (en)
CA (1) CA2250583C (en)
IL (1) IL126071A (en)
NO (1) NO984490L (en)
NZ (1) NZ331432A (en)
WO (1) WO1997035874A1 (en)
ZA (1) ZA972506B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors

Also Published As

Publication number Publication date
AU2055097A (en) 1997-10-17
CN1214691A (en) 1999-04-21
JP2000507267A (en) 2000-06-13
EP1012165A1 (en) 2000-06-28
WO1997035874A1 (en) 1997-10-02
NO984490D0 (en) 1998-09-25
NO984490L (en) 1998-09-25
CA2250583C (en) 2003-01-14
AU710040B2 (en) 1999-09-09
ZA972506B (en) 1997-09-26
CN1121410C (en) 2003-09-17
NZ331432A (en) 2000-03-27
AR006366A1 (en) 1999-08-25
CA2250583A1 (en) 1997-10-02
IL126071A0 (en) 1999-05-09
KR20000004991A (en) 2000-01-25
BR9708369A (en) 1999-08-03

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees