AR006366A1 - PROCEDURE FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- [1- [3 - [(AMINOIMINOMETIL) AMINO] PROPIL] -3,3-DIFLUORO-2-OXOHEXIL] -L-PROLINAMIDE - Google Patents

PROCEDURE FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- [1- [3 - [(AMINOIMINOMETIL) AMINO] PROPIL] -3,3-DIFLUORO-2-OXOHEXIL] -L-PROLINAMIDE

Info

Publication number
AR006366A1
AR006366A1 ARP970101169A ARP970101169A AR006366A1 AR 006366 A1 AR006366 A1 AR 006366A1 AR P970101169 A ARP970101169 A AR P970101169A AR P970101169 A ARP970101169 A AR P970101169A AR 006366 A1 AR006366 A1 AR 006366A1
Authority
AR
Argentina
Prior art keywords
prolinamide
phenylalanyl
difluoro
amino
methyl
Prior art date
Application number
ARP970101169A
Other languages
Spanish (es)
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR006366A1 publication Critical patent/AR006366A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedimiento para preparar N-metil-D-fenilalanil-N-[1-[3-[(amino] propil]-3,3-difluoro-2-oxohexil]-L-prolinamida o una sal farmacéuticamenteaceptable de la misma y un intermediario clave por guanilación directa de intermediarios deDa kin-West.Process for preparing N-methyl-D-phenylalanyl-N- [1- [3 - [(amino] propyl] -3,3-difluoro-2-oxohexyl] -L-prolinamide or a pharmaceutically acceptable salt thereof and an intermediate key by direct guanylation of Da kin-West intermediates.

ARP970101169A 1996-03-26 1997-03-24 PROCEDURE FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- [1- [3 - [(AMINOIMINOMETIL) AMINO] PROPIL] -3,3-DIFLUORO-2-OXOHEXIL] -L-PROLINAMIDE AR006366A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62472196A 1996-03-26 1996-03-26

Publications (1)

Publication Number Publication Date
AR006366A1 true AR006366A1 (en) 1999-08-25

Family

ID=24503070

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101169A AR006366A1 (en) 1996-03-26 1997-03-24 PROCEDURE FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- [1- [3 - [(AMINOIMINOMETIL) AMINO] PROPIL] -3,3-DIFLUORO-2-OXOHEXIL] -L-PROLINAMIDE

Country Status (13)

Country Link
EP (1) EP1012165A1 (en)
JP (1) JP2000507267A (en)
KR (1) KR20000004991A (en)
CN (1) CN1121410C (en)
AR (1) AR006366A1 (en)
AU (1) AU710040B2 (en)
BR (1) BR9708369A (en)
CA (1) CA2250583C (en)
IL (1) IL126071A (en)
NO (1) NO984490L (en)
NZ (1) NZ331432A (en)
WO (1) WO1997035874A1 (en)
ZA (1) ZA972506B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors

Also Published As

Publication number Publication date
AU2055097A (en) 1997-10-17
CN1214691A (en) 1999-04-21
JP2000507267A (en) 2000-06-13
EP1012165A1 (en) 2000-06-28
WO1997035874A1 (en) 1997-10-02
NO984490D0 (en) 1998-09-25
NO984490L (en) 1998-09-25
CA2250583C (en) 2003-01-14
AU710040B2 (en) 1999-09-09
IL126071A (en) 2003-06-24
ZA972506B (en) 1997-09-26
CN1121410C (en) 2003-09-17
NZ331432A (en) 2000-03-27
CA2250583A1 (en) 1997-10-02
IL126071A0 (en) 1999-05-09
KR20000004991A (en) 2000-01-25
BR9708369A (en) 1999-08-03

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal