CA2245398E - Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention - Google Patents

Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention

Info

Publication number
CA2245398E
CA2245398E CA2245398A CA2245398A CA2245398E CA 2245398 E CA2245398 E CA 2245398E CA 2245398 A CA2245398 A CA 2245398A CA 2245398 A CA2245398 A CA 2245398A CA 2245398 E CA2245398 E CA 2245398E
Authority
CA
Canada
Prior art keywords
azithromycin
isopropanol
degree
water
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2245398A
Other languages
English (en)
Other versions
CA2245398A1 (fr
CA2245398C (fr
Inventor
Khashayar Karimian
Mehrnoush Motamedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Apotex Inc
Apotex Technologies Inc
Filing date
Publication date
Application filed by Apotex Inc, Apotex Technologies Inc filed Critical Apotex Inc
Priority claimed from CA002245398A external-priority patent/CA2245398C/fr
Priority to CA002245398A priority Critical patent/CA2245398C/fr
Priority to US09/373,549 priority patent/US6245903B1/en
Priority to EP99306612A priority patent/EP0984020B1/fr
Priority to DE69902212T priority patent/DE69902212T2/de
Priority to AT99306612T priority patent/ATE221078T1/de
Publication of CA2245398A1 publication Critical patent/CA2245398A1/fr
Publication of CA2245398E publication Critical patent/CA2245398E/fr
Publication of CA2245398C publication Critical patent/CA2245398C/fr
Application granted granted Critical
Priority to US10/454,586 priority patent/USRE39087E1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

CA002245398A 1998-08-21 1998-08-21 Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention Expired - Fee Related CA2245398C (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002245398A CA2245398C (fr) 1998-08-21 1998-08-21 Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention
US09/373,549 US6245903B1 (en) 1998-08-21 1999-08-13 Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AT99306612T ATE221078T1 (de) 1998-08-21 1999-08-20 Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung
DE69902212T DE69902212T2 (de) 1998-08-21 1999-08-20 Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung
EP99306612A EP0984020B1 (fr) 1998-08-21 1999-08-20 Clathrates d'azithromycine monohydratée et d'isopropanol ainsi que leur méthode de fabrication
US10/454,586 USRE39087E1 (en) 1998-08-21 2003-06-05 Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002245398A CA2245398C (fr) 1998-08-21 1998-08-21 Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention

Publications (3)

Publication Number Publication Date
CA2245398A1 CA2245398A1 (fr) 2000-02-21
CA2245398E true CA2245398E (fr) 2002-01-29
CA2245398C CA2245398C (fr) 2002-01-29

Family

ID=4162751

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002245398A Expired - Fee Related CA2245398C (fr) 1998-08-21 1998-08-21 Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention

Country Status (5)

Country Link
US (2) US6245903B1 (fr)
EP (1) EP0984020B1 (fr)
AT (1) ATE221078T1 (fr)
CA (1) CA2245398C (fr)
DE (1) DE69902212T2 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (fr) 1998-08-21 2002-01-29 Apotex Inc. Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention
JP2002531409A (ja) * 1998-11-30 2002-09-24 テバ ファーマシューティカル インダストリーズ リミティド アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤
ATE469910T1 (de) * 1999-06-29 2010-06-15 Sandoz Ag Azithromycinmonohydrat
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
ATE320441T1 (de) 2000-07-25 2006-04-15 Silanes Sa De Cv Lab Einstufiges verfahren zur herstellung von 7,16-
AU2001214115A1 (en) * 2000-08-01 2002-02-13 Habil F. Khorakiwala Process for the preparation of anhydrous azithromycin
DE60114028T2 (de) * 2000-08-23 2006-07-13 Wockhardt Ltd. Verfahren zur herstellung von wasserfreiem azithromycin
RU2279439C2 (ru) * 2000-11-27 2006-07-10 Сандоз Аг Азитромицин в форме моногидрата и способ его получения
CA2429639C (fr) * 2000-11-27 2009-07-14 Biochemie S.A. Monohydrate d'azithromycine stable
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
EP1671979B1 (fr) * 2001-05-22 2008-08-13 Pfizer Products Inc. Nouvelle forme cristalline de l'azithromycine
IL158591A0 (en) * 2001-05-22 2004-05-12 Pfizer Prod Inc Crystal forms of azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1455757A2 (fr) * 2001-12-21 2004-09-15 Pfizer Products Inc. Procedes de granulation par voie humide d'azithromycine
IL161996A0 (en) * 2001-12-21 2005-11-20 Pfizer Prod Inc Directly compressible formulations of azithromycin
BR0307331A (pt) * 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
CA2422972A1 (fr) * 2003-03-21 2004-09-21 Apotex Inc. Isopropanolate d'azithromycine et methode de production connexe
WO2005002592A2 (fr) * 2003-07-01 2005-01-13 Ranbaxy Laboratories Limited Compositions orales stables de monohydrate d'azithromycine
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
WO2005009447A1 (fr) 2003-07-24 2005-02-03 Pliva - Research And Development Ltd. Dose unique a dissolution rapide d'azithromycine
CA2549225A1 (fr) * 2003-12-04 2005-06-16 Pfizer Products Inc. Procede d'atomisation/congelation faisant appel a une extrudeuse pour la preparation de compositions medicamenteuses cristallines multiparticulaires contenant de preference un poloxamere et un glyceride
JP2007513145A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 医薬用多微粒子の製造方法
WO2005053639A2 (fr) * 2003-12-04 2005-06-16 Pfizer Products Inc. Formes multiparticulaires a liberation controlee produites avec des optimiseurs de dissolution
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
CA2547239A1 (fr) * 2003-12-04 2005-06-16 Pfizer Products Inc. Formes posologiques multiparticulaires d'azithromycine obtenues par des procedes se deroulant en milieu liquide
WO2005053652A1 (fr) 2003-12-04 2005-06-16 Pfizer Products Inc. Compositions medicamenteuses cristallines multiparticulaires contenant un poloxamere et un glyceride
JP2007513139A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7235646B2 (en) * 2004-06-28 2007-06-26 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
US20090130154A1 (en) * 2004-08-26 2009-05-21 Bioderm Research Topical Delivery of Biological and Cosmetic Agents by Zeolites
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
WO2006067577A2 (fr) * 2004-12-21 2006-06-29 Pfizer Products Inc. Suspension orales stables d'azithromycine sous forme non dihydrate
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US20090318375A1 (en) * 2005-06-08 2009-12-24 Hanmi Pharm Co., Ltd Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
US20100158821A1 (en) * 2008-12-22 2010-06-24 Eastman Chemical Company Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
US20120058936A1 (en) 2009-03-13 2012-03-08 Assistance Publique - Hopitaux De Paris Compositions and methods for elimination of gram negative bacteria
US8106111B2 (en) * 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
BR112012014926A2 (pt) 2009-12-18 2015-09-15 Univ Northwest composição compreendendo uma forma vítrea não cristalina e amorfa de azitromicina
WO2013088274A1 (fr) 2011-12-14 2013-06-20 Wockhardt Limited Composition d'azithromycine amorphe anhydre dépourvue de dihydrate d'azithromycine

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
JPS58157790A (ja) 1982-03-16 1983-09-19 Takeda Chem Ind Ltd ７−デアザプリン誘導体およびその製造法
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
CA1202619A (fr) 1982-07-19 1986-04-01 Gene M. Bright Produits intermediaires pour la preparation de n-methyl 11-aza-10-desoxo-10-dihydroerythromycine a
RO107257B1 (ro) 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
CN1093370A (zh) 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
PT915899E (pt) 1996-07-29 2004-11-30 Abbott Lab Preparacao da forma cristalina ii da eritromicina
CN1157402C (zh) * 1997-07-08 2004-07-14 生物化学股份有限公司 有机化合物
CA2245398C (fr) 1998-08-21 2002-01-29 Apotex Inc. Clathrate d'isopropanol monohydrate d'azithromycine et methodes d'obtention
KR100377159B1 (ko) 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
JP2002531409A (ja) 1998-11-30 2002-09-24 テバ ファーマシューティカル インダストリーズ リミティド アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤
ATE469910T1 (de) 1999-06-29 2010-06-15 Sandoz Ag Azithromycinmonohydrat
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina

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