CA2233012A1 - Compounds enhancing the activity of retinoids - Google Patents

Compounds enhancing the activity of retinoids Download PDF

Info

Publication number
CA2233012A1
CA2233012A1 CA002233012A CA2233012A CA2233012A1 CA 2233012 A1 CA2233012 A1 CA 2233012A1 CA 002233012 A CA002233012 A CA 002233012A CA 2233012 A CA2233012 A CA 2233012A CA 2233012 A1 CA2233012 A1 CA 2233012A1
Authority
CA
Canada
Prior art keywords
compound
hexano
dimethyl
benzoic acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002233012A
Other languages
English (en)
French (fr)
Inventor
Koichi Shudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Medicinal Molecular Design Inc IMMD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2233012A1 publication Critical patent/CA2233012A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thin Film Transistor (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA002233012A 1995-09-21 1996-09-20 Compounds enhancing the activity of retinoids Abandoned CA2233012A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24263995 1995-09-21
JP7/242639 1995-09-21
JP8/150582 1996-06-12
JP15058296 1996-06-12

Publications (1)

Publication Number Publication Date
CA2233012A1 true CA2233012A1 (en) 1997-03-27

Family

ID=26480129

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002233012A Abandoned CA2233012A1 (en) 1995-09-21 1996-09-20 Compounds enhancing the activity of retinoids

Country Status (13)

Country Link
US (3) US5929069A (enExample)
EP (1) EP0906907B1 (enExample)
KR (1) KR100484294B1 (enExample)
CN (1) CN1121395C (enExample)
AT (1) ATE214055T1 (enExample)
AU (1) AU7001596A (enExample)
CA (1) CA2233012A1 (enExample)
DE (1) DE69619711T2 (enExample)
DK (1) DK0906907T3 (enExample)
EA (1) EA002123B1 (enExample)
NO (1) NO981269L (enExample)
TW (1) TW420667B (enExample)
WO (1) WO1997011061A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484294B1 (ko) * 1995-09-21 2005-09-09 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 레티노이드작용증강성화합물
AU1052599A (en) * 1997-11-12 1999-05-31 Institute Of Medicinal Molecular Design. Inc. Retinoid receptor agonists
JP4204657B2 (ja) * 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
US6869959B1 (en) 1999-04-28 2005-03-22 Institute Of Medicinal Molecular Design Inc. Heterocyclic carboxylic acid derivatives
CA2372150C (en) * 1999-04-30 2011-08-30 The Regents Of The University Of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
JP4654126B2 (ja) * 2003-03-20 2011-03-16 財団法人乙卯研究所 器官形成方法
GB0308335D0 (en) 2003-04-10 2003-05-14 Novartis Ag Organic compounds
KR20070007818A (ko) 2004-03-10 2007-01-16 재단법인 이쯔우 연구소 기억 고정 촉진제
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び／又は治療のための医薬
EP1893218A4 (en) 2005-06-01 2011-01-12 Univ Michigan UNLOCKED BENZODIAZEPINE COMPOSITIONS AND METHOD
CN102058571B (zh) * 2005-09-09 2012-09-19 有限会社肯菲思 4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)氨基甲酰基]苯甲酸在制备用于预防及/或治疗肠疾病的药物中的应用
CA2628193C (en) 2005-11-01 2012-08-14 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
MX2008015488A (es) 2006-06-09 2009-02-12 Univ Michigan Composiciones y metodos relacionados con compuestos novedosos y objetivos de los mismos.
JP2008081427A (ja) * 2006-09-27 2008-04-10 R&R Inc 分泌障害性疾患の予防及び／又は治療のための医薬
US7902260B2 (en) * 2007-02-28 2011-03-08 Kemphys Ltd. Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom
BRPI0808653A2 (pt) 2007-03-09 2014-08-19 Univ Michigan Composições e métodos referindo-se a novos compostos e alvos dos mesmos.
EA201070274A1 (ru) 2007-08-15 2010-10-29 Рисерч Фаундейшн Ицуу Лэборетери Трициклическое аминное соединение
ES2614498T3 (es) 2007-09-14 2017-05-31 The Regents Of The University Of Michigan Inhibidores de ATPasa F1F0 y métodos relacionados
AU2008323945B2 (en) 2007-11-06 2013-11-28 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
EP2352724B1 (en) 2008-09-11 2015-04-22 The Regents of the University of Michigan Aryl guanidine f1f0-atpase inhibitors and their medical use
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
WO2011037128A1 (ja) 2009-09-28 2011-03-31 日本曹達株式会社 含窒素ヘテロ環化合物およびその塩ならびに農園芸用殺菌剤
CA2780333C (en) 2009-11-17 2016-05-24 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
JP5856064B2 (ja) 2009-11-17 2016-02-09 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
WO2012112623A2 (en) * 2011-02-14 2012-08-23 Sloan-Kettering Institute For Cancer Research Rxrg modulators for the treatment of cancer
WO2012151512A2 (en) 2011-05-04 2012-11-08 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
CN103304494B (zh) * 2013-06-20 2015-05-27 河北大学 茚(1,2-b)喹喔啉-11-酮肟衍生物及其制备方法和用途
PT3157928T (pt) 2014-06-20 2019-05-30 Constellation Pharmaceuticals Inc Formas cristalinas de 2-((4s)-6-(4-clorofenil)-1-metil-4h-benzo[c] isoxazolo[4,5-e]azepin-4-il)acetamida
KR200489267Y1 (ko) 2018-09-20 2019-05-23 김은진 폭 조절형 옷걸이
KR200490993Y1 (ko) 2019-06-14 2020-02-04 이현봉 구김방지기능을 구비한 바지걸이
CN114702454A (zh) * 2022-03-29 2022-07-05 江西师范大学 5-烷基-11-芳基-5H-二苯并[b,e][1,4]二氮杂卓衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211071A (ja) * 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
KR100484294B1 (ko) * 1995-09-21 2005-09-09 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 레티노이드작용증강성화합물
JP4204657B2 (ja) * 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤

Also Published As

Publication number Publication date
NO981269L (no) 1998-05-20
EP0906907A1 (en) 1999-04-07
KR100484294B1 (ko) 2005-09-09
ATE214055T1 (de) 2002-03-15
DK0906907T3 (da) 2002-04-22
CN1121395C (zh) 2003-09-17
EA002123B1 (ru) 2001-12-24
EP0906907A4 (enExample) 1999-04-07
TW420667B (en) 2001-02-01
US5929069A (en) 1999-07-27
US6476017B2 (en) 2002-11-05
US6121256A (en) 2000-09-19
DE69619711D1 (de) 2002-04-11
DE69619711T2 (de) 2002-10-17
KR19990063661A (ko) 1999-07-26
EA199800318A1 (ru) 1998-10-29
NO981269D0 (no) 1998-03-20
AU7001596A (en) 1997-04-09
CN1202160A (zh) 1998-12-16
US20010039272A1 (en) 2001-11-08
WO1997011061A1 (en) 1997-03-27
EP0906907B1 (en) 2002-03-06

Similar Documents

Publication Publication Date Title
CA2233012A1 (en) Compounds enhancing the activity of retinoids
KR100483442B1 (ko) 레티노이드형생리활성을갖는테트라히드로나프타렌,크로만,티오크로만및1,2,3,4-테트라히드퀴놀린카르복실산의아릴또는헤테로아릴아미드
US4912108A (en) Pyridoquinoxaline compounds and their preparation and use as glutamate antagonists
RU2163906C2 (ru) Арил- или гетероариламиды тетрагидронафталин-, хроман-, тиохроман- и 1,2,3,4-тетрагидрохинолинкарбоновых кислот, проявляющие ретиноидоподобную биологическую активность
US5109001A (en) Fused 2,3-dihydroxydiazolo compounds and their preparation and use
EP0839136A1 (en) BENZO[g]QUINOLINE DERIVATIVES
JPH08503202A (ja) 治療剤
JP3865829B2 (ja) レチノイド作用増強性化合物
US3845065A (en) 4-oxo-4,5-dihydrothieno(3,2-c)pyridines
EP0874812A1 (fr) Nouveaux derives de 2,3,5 trimethyl-4-hydroxy anilides, leur preparation et leur application en therapeutique
EP1137413B1 (en) Non-peptide antagonists of glp-1 receptor and methods of use
JPH10338658A (ja) レチノイド作用調節剤
EP0667344A1 (fr) 3-acylamino-5-(phényl polysubstitué)-1,4-benzodiazépin-2-ones utiles comme abonistes du récepteur CCK
US3501483A (en) Novel 11-(4-piperidyl)dibenz(b,f)(1,4) oxazepines and thiazepines
EP0383690A1 (fr) Nouveaux dérivés de l'acide 2-amino pentanedioique, leur procédé et les intermédiaires de préparation, leur application comme médicaments et les compositons les renfermant
JP4005160B2 (ja) レチノイドアンタゴニスト
WO1999007669A1 (en) Anthranilic acid analogs
US3723466A (en) Tricyclic compounds
Narayanan Adamantyl analogs of the antidepressive, 5-(2-dimethylaminoethyl)-2, 3-dihydro-2-phenyl-1, 5-benzothiazepin-4 (5H))-one
US3845074A (en) Dibenzo(b,f)thiazepin(1,4)-11-yl amino alkanoic acids
JPH09100270A (ja) レチノイドアンタゴニスト
FR2716194A1 (fr) Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
JP2520318B2 (ja) スルホニルアルキルカルボン酸誘導体
KR790001682B1 (ko) 이종환상(異種環狀)화합물의 제조방법
JPH07119204B2 (ja) フェニルスルフィニルアルキルカルボン酸誘導体

Legal Events

Date Code Title Description
FZDE Discontinued