CA2224103A1 - Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions - Google Patents
Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions Download PDFInfo
- Publication number
- CA2224103A1 CA2224103A1 CA002224103A CA2224103A CA2224103A1 CA 2224103 A1 CA2224103 A1 CA 2224103A1 CA 002224103 A CA002224103 A CA 002224103A CA 2224103 A CA2224103 A CA 2224103A CA 2224103 A1 CA2224103 A1 CA 2224103A1
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- CA
- Canada
- Prior art keywords
- quinone
- indol
- dihydroxy
- methylbut
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47613695A | 1995-06-07 | 1995-06-07 | |
| US476,136 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2224103A1 true CA2224103A1 (en) | 1996-12-19 |
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ID=23890650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002224103A Abandoned CA2224103A1 (en) | 1995-06-07 | 1996-06-05 | Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US5780496A (enExample) |
| EP (1) | EP0831809A4 (enExample) |
| JP (1) | JPH11506770A (enExample) |
| KR (1) | KR19990022369A (enExample) |
| CN (1) | CN1192680A (enExample) |
| AR (1) | AR003140A1 (enExample) |
| BR (1) | BR9609353A (enExample) |
| CA (1) | CA2224103A1 (enExample) |
| IL (1) | IL122427A0 (enExample) |
| MX (1) | MX9709442A (enExample) |
| WO (1) | WO1996040115A1 (enExample) |
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| US8688188B2 (en) * | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
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| US7226991B1 (en) * | 1999-03-23 | 2007-06-05 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
| WO2001028577A2 (en) | 1999-10-22 | 2001-04-26 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Inhibition of cell motility and angiogenesis by inhibitors of the grb2 sh2-domain |
| US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
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| US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
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| US7151162B2 (en) * | 2001-12-06 | 2006-12-19 | The University Of Children's Hospital Of Both Cantons Of Basel | Nuclear protein |
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| US20040138104A1 (en) * | 2003-01-14 | 2004-07-15 | The Government Of The United States Of America Represented By The Secretary, | Peptides |
| US20050119163A1 (en) * | 2003-09-18 | 2005-06-02 | The Government Of The United States Of America, As Represented By The Secretary, | SH2 domain binding inhibitors |
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| JP2008532926A (ja) * | 2004-12-06 | 2008-08-21 | アバンテイス・フアルマ・エス・アー | 置換インドール化合物、それを含有する組成物、この製造方法およびこの使用 |
| FR2878849B1 (fr) * | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| AR065804A1 (es) | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
| US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
| NZ601635A (en) * | 2010-01-27 | 2013-06-28 | Takeda Pharmaceutical | Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent |
| US9912758B2 (en) | 2014-12-16 | 2018-03-06 | Yahoo Holdings, Inc. | Continuing an application session on a different device |
| CN120365272A (zh) | 2018-10-05 | 2025-07-25 | 安娜普尔纳生物股份有限公司 | 用于治疗与apj受体活性有关的疾病的化合物和组合物 |
| KR102267662B1 (ko) * | 2019-11-19 | 2021-06-22 | 한국화학연구원 | 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
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| US3917820A (en) * | 1969-05-29 | 1975-11-04 | Canadian Patents Dev | Antibiotic cochliodinol and production by chaetomium, cochliodes and chaetomium globsum |
| JPH0236591B2 (ja) * | 1979-08-27 | 1990-08-17 | Kyoto Pharma Ind | Kinonjudotai |
| JPS6191167A (ja) * | 1984-10-08 | 1986-05-09 | Kyoto Yakuhin Kogyo Kk | キノン誘導体 |
| JPS6360966A (ja) * | 1986-08-29 | 1988-03-17 | Kyoto Yakuhin Kogyo Kk | キノン誘導体 |
| SE8903455D0 (sv) * | 1989-10-19 | 1989-10-19 | Joakim Nelson | Dynamiska digitala foerbindelsenaet (dfn) |
| US5469431A (en) * | 1993-07-12 | 1995-11-21 | Philips Electronics North America Corp. | Method of and apparatus for channel mapping with relative service identification |
| DE4329010A1 (de) * | 1993-08-28 | 1995-03-02 | Sel Alcatel Ag | Funksystem |
| US6205143B1 (en) * | 1996-03-14 | 2001-03-20 | Telefonaktiebolaget L M Ericsson | System supporting variable bandwidth asynchronous transfer mode network access for wireline and wireless communications |
| US5841777A (en) * | 1996-08-30 | 1998-11-24 | Hewlett-Packard Company | System and method for accommodating ABR and CBR traffic on a shared communications channel |
| US6363058B1 (en) * | 1997-09-24 | 2002-03-26 | Telefonaktiebolaget L M Ericsson (Publ) | Multi-service handling by a single mobile station |
| FI980293A7 (fi) * | 1998-02-09 | 1999-08-10 | Nokia Corp | Multimedia- ja monipalvelupuhelut matkaviestinverkossa |
| CN1284243A (zh) * | 1998-11-30 | 2001-02-14 | 诺基亚网络有限公司 | 空中接口容量调度方法 |
-
1996
- 1996-06-05 CA CA002224103A patent/CA2224103A1/en not_active Abandoned
- 1996-06-05 KR KR1019970708849A patent/KR19990022369A/ko not_active Withdrawn
- 1996-06-05 JP JP9501241A patent/JPH11506770A/ja not_active Ceased
- 1996-06-05 US US08/658,337 patent/US5780496A/en not_active Expired - Fee Related
- 1996-06-05 CN CN96196106A patent/CN1192680A/zh active Pending
- 1996-06-05 EP EP96917126A patent/EP0831809A4/en not_active Withdrawn
- 1996-06-05 BR BR9609353A patent/BR9609353A/pt not_active Application Discontinuation
- 1996-06-05 IL IL12242796A patent/IL122427A0/xx unknown
- 1996-06-05 MX MX9709442A patent/MX9709442A/es not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/008741 patent/WO1996040115A1/en not_active Ceased
- 1996-06-11 AR ARP960103099A patent/AR003140A1/es unknown
-
1998
- 1998-06-04 US US09/090,737 patent/US6090838A/en not_active Expired - Fee Related
-
2000
- 2000-05-05 US US09/565,855 patent/US6239161B1/en not_active Expired - Fee Related
-
2001
- 2001-05-14 US US09/854,424 patent/US20020016353A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL122427A0 (en) | 1998-06-15 |
| WO1996040115A1 (en) | 1996-12-19 |
| AR003140A1 (es) | 1998-07-08 |
| US20020016353A1 (en) | 2002-02-07 |
| US6239161B1 (en) | 2001-05-29 |
| BR9609353A (pt) | 1999-05-11 |
| JPH11506770A (ja) | 1999-06-15 |
| CN1192680A (zh) | 1998-09-09 |
| EP0831809A1 (en) | 1998-04-01 |
| MX9709442A (es) | 1998-02-28 |
| KR19990022369A (ko) | 1999-03-25 |
| AU5979996A (en) | 1996-12-30 |
| EP0831809A4 (en) | 2001-11-28 |
| US5780496A (en) | 1998-07-14 |
| AU697120B2 (en) | 1998-09-24 |
| US6090838A (en) | 2000-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20050606 |