CA2223940A1 - Macrophage activating factors derived from cloned vitamin d binding protein - Google Patents
Macrophage activating factors derived from cloned vitamin d binding protein Download PDFInfo
- Publication number
- CA2223940A1 CA2223940A1 CA002223940A CA2223940A CA2223940A1 CA 2223940 A1 CA2223940 A1 CA 2223940A1 CA 002223940 A CA002223940 A CA 002223940A CA 2223940 A CA2223940 A CA 2223940A CA 2223940 A1 CA2223940 A1 CA 2223940A1
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- Prior art keywords
- protein
- cloned
- macrophage activating
- activating factor
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 208000024719 uterine cervix neoplasm Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
-
- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/478,121 | 1995-06-07 | ||
| US08/478,121 US5620846A (en) | 1995-06-07 | 1995-06-07 | Diagnostic and prognostic indices for cancer and aids |
| US08/618,485 US6410269B1 (en) | 1995-06-07 | 1996-03-19 | Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis |
| US08/618,485 | 1996-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2223940A1 true CA2223940A1 (en) | 1996-12-19 |
Family
ID=27045792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002223940A Abandoned CA2223940A1 (en) | 1995-06-07 | 1996-06-05 | Macrophage activating factors derived from cloned vitamin d binding protein |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6410269B1 (enExample) |
| EP (3) | EP1443112A3 (enExample) |
| JP (1) | JPH11511962A (enExample) |
| CN (2) | CN1174097C (enExample) |
| AT (1) | ATE307885T1 (enExample) |
| AU (1) | AU6253596A (enExample) |
| BR (1) | BR9609072A (enExample) |
| CA (1) | CA2223940A1 (enExample) |
| DE (2) | DE69635346D1 (enExample) |
| ES (1) | ES2252756T3 (enExample) |
| NO (1) | NO323155B1 (enExample) |
| WO (1) | WO1996040903A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985545A (en) * | 1996-03-19 | 1999-11-16 | Yamamoto; Nobuto | Diagnostic and prognostic ELISA assays of serum α-N-acetylgalactosaminidase for AIDS |
| AU6137801A (en) * | 2000-05-09 | 2001-11-20 | Childrens Medical Center | Method and composition for the treatment of angiogenesis |
| US20050009120A1 (en) * | 2000-09-07 | 2005-01-13 | The Brigham And Women's Hospital, Inc. | Methods of detecting ovarian cancer based on osteopontin |
| US6846642B2 (en) * | 2000-09-07 | 2005-01-25 | The Brigham And Women's Hospital, Inc. | Methods of detecting cancer based on prostasin |
| AU2002246849A1 (en) * | 2000-11-09 | 2002-08-06 | Northeastern Ohio Universities College Of Medicine | Agents and methods for promoting bone growth |
| WO2002075314A2 (en) * | 2000-11-30 | 2002-09-26 | Matritech, Inc. | Detection and treatment of prostate cancer |
| US7112408B2 (en) * | 2001-06-08 | 2006-09-26 | The Brigham And Women's Hospital, Inc. | Detection of ovarian cancer based upon alpha-haptoglobin levels |
| US6806355B2 (en) | 2001-08-14 | 2004-10-19 | Statens Serum Institut | Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product |
| US7288383B2 (en) * | 2003-01-15 | 2007-10-30 | The Brigham And Women's Hospital, Inc. | Eosinophil-derived neurotoxin as a marker for ovarian cancer |
| US8034773B2 (en) | 2004-02-05 | 2011-10-11 | Arizona Biomedical Research Commission | Immunostimulatory compositions and uses thereof |
| US20050186577A1 (en) * | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
| WO2006063028A2 (en) * | 2004-12-07 | 2006-06-15 | The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Immunostimulatory compositions and uses thereof |
| USRE46425E1 (en) | 2006-12-13 | 2017-06-06 | Susavion Biosciences, Inc. | Pro-angiogenic peptides and uses thereof |
| US8460697B2 (en) | 2006-12-13 | 2013-06-11 | Susavion Biosciences, Inc. | Pro-angiogenic peptides and uses thereof |
| US7838497B2 (en) | 2006-12-13 | 2010-11-23 | Susavion Biosciences, Inc. | Pro-angiogenic peptides |
| US8496942B2 (en) | 2006-12-13 | 2013-07-30 | Susavion Biosciences, Inc. | Therapeutic peptides and uses thereof |
| US7811995B2 (en) | 2006-12-13 | 2010-10-12 | Susavion Biosciences, Inc. | Therapeutic and diagnostic peptides |
| AU2010289901A1 (en) * | 2009-08-22 | 2012-03-15 | Charles Knezevich | Tumoricidal, bactericidal, or viricidal macrophage activation |
| JP5860401B2 (ja) | 2010-09-03 | 2016-02-16 | 森田薬品工業株式会社 | 新規Ｇｃグロブリンガラクトース脱糖体の製造方法 |
| CA2832487A1 (en) | 2011-04-07 | 2012-10-11 | Efranat Ltd. | Macrophage activating factor for pharmaceutical compositions |
| EP2561879A1 (en) | 2011-08-23 | 2013-02-27 | Protea Biopharma N.V. | Macrophage activating factor for use in the treatment of chronic fatigue syndrome (CFS) and CFS-related diseases and disorders |
| EP2819749A4 (en) * | 2012-03-01 | 2016-03-02 | Univ Columbia | BIOMARKERS FOR AUTISM AND USES THEREOF |
| EP2687264A1 (en) | 2012-07-17 | 2014-01-22 | Protea Biopharma N.V. | Macrophage Activating Factor for treatment of endometriosis |
| KR20150107738A (ko) * | 2013-01-18 | 2015-09-23 | 엘리스 클라인 | 암의 면역 프로그래밍 및 치료를 위한 선택적 글라이코시다제 섭생 |
| AU2014279627A1 (en) * | 2013-06-09 | 2015-12-03 | Efranat Ltd. | Compositions comprising Gc- macrophage activating factor and uses thereof |
| AT518622A1 (de) * | 2016-04-21 | 2017-11-15 | Hg Pharma Gmbh | Dimerer Komplex aus selektiv deglycosyliertem Vitamin D bindenden Protein (GcMAF) und Cholecalciferol (Calciol) und Verfahren zu dessen Herstellung |
| JP6718561B2 (ja) * | 2017-12-15 | 2020-07-08 | 公益財団法人神戸医療産業都市推進機構 | 活性型ＧｃＭＡＦの製造方法 |
| AU2021398261A1 (en) | 2020-12-08 | 2023-07-06 | Saisei Pharma Co., Ltd. | Macrophage activator |
| CN118325844B (zh) * | 2023-09-07 | 2025-01-03 | 武汉奥科博泰生物科技有限公司 | 识别N-乙酰-β-D-氨基葡萄糖苷酶的单克隆抗体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177002A (en) * | 1989-11-20 | 1993-01-05 | Nobuto Yamamoto | In vitro enzymatic conversion of glycosylated human vitamin D binding protein to a potent macrophage activating factor |
| US5177001A (en) | 1989-11-20 | 1993-01-05 | Nobuto Yamamoto | In vitro enzymatic conversion of glycosylated mammalian vitamin D-binding protein to a potent macrophage activating factor |
| US5326749A (en) | 1989-11-20 | 1994-07-05 | Nobuto Yamamoto | Macrophage activating factor from vitamin D binding protein |
| US5516657A (en) * | 1992-05-11 | 1996-05-14 | Cambridge Biotech Corporation | Baculovirus vectors for expression of secretory and membrane-bound proteins |
| US5652352A (en) * | 1994-03-31 | 1997-07-29 | Amgen Inc. | Afamin: a human serum albumin-like gene |
-
1996
- 1996-03-19 US US08/618,485 patent/US6410269B1/en not_active Expired - Lifetime
- 1996-06-05 EP EP04076092A patent/EP1443112A3/en not_active Withdrawn
- 1996-06-05 BR BR9609072-3A patent/BR9609072A/pt not_active Application Discontinuation
- 1996-06-05 AU AU62535/96A patent/AU6253596A/en not_active Abandoned
- 1996-06-05 EP EP96921279A patent/EP0837932B1/en not_active Expired - Lifetime
- 1996-06-05 ES ES96921279T patent/ES2252756T3/es not_active Expired - Lifetime
- 1996-06-05 EP EP03075633A patent/EP1340815A3/en not_active Withdrawn
- 1996-06-05 CN CNB961958081A patent/CN1174097C/zh not_active Expired - Fee Related
- 1996-06-05 CA CA002223940A patent/CA2223940A1/en not_active Abandoned
- 1996-06-05 JP JP9501337A patent/JPH11511962A/ja not_active Ceased
- 1996-06-05 AT AT96921279T patent/ATE307885T1/de not_active IP Right Cessation
- 1996-06-05 DE DE69635346A patent/DE69635346D1/de not_active Expired - Lifetime
- 1996-06-05 DE DE69635346T patent/DE69635346T4/de not_active Expired - Lifetime
- 1996-06-05 WO PCT/US1996/008867 patent/WO1996040903A1/en not_active Ceased
- 1996-06-05 CN CNA031480365A patent/CN1510147A/zh active Pending
-
1997
- 1997-01-06 US US08/779,729 patent/US5712104A/en not_active Expired - Lifetime
- 1997-12-08 NO NO19975771A patent/NO323155B1/no not_active IP Right Cessation
-
2001
- 2001-04-05 US US09/826,463 patent/US20020055140A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO975771L (no) | 1998-01-30 |
| US6410269B1 (en) | 2002-06-25 |
| JPH11511962A (ja) | 1999-10-19 |
| EP0837932A1 (en) | 1998-04-29 |
| AU6253596A (en) | 1996-12-30 |
| EP1340815A3 (en) | 2003-09-17 |
| US20020055140A1 (en) | 2002-05-09 |
| DE69635346T4 (de) | 2007-11-08 |
| CN1174097C (zh) | 2004-11-03 |
| NO323155B1 (no) | 2007-01-08 |
| EP1443112A3 (en) | 2004-11-03 |
| EP0837932B1 (en) | 2005-10-26 |
| EP1443112A2 (en) | 2004-08-04 |
| ATE307885T1 (de) | 2005-11-15 |
| EP1340815A2 (en) | 2003-09-03 |
| ES2252756T3 (es) | 2006-05-16 |
| DE69635346T2 (de) | 2006-07-27 |
| DE69635346D1 (de) | 2005-12-01 |
| NO975771D0 (no) | 1997-12-08 |
| US5712104A (en) | 1998-01-27 |
| CN1510147A (zh) | 2004-07-07 |
| WO1996040903A1 (en) | 1996-12-19 |
| EP0837932A4 (en) | 2001-02-28 |
| CN1191567A (zh) | 1998-08-26 |
| BR9609072A (pt) | 2000-10-24 |
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