CN1174097C - 由克隆的维生素d结合蛋白衍生的巨噬细胞激活因子 - Google Patents

由克隆的维生素d结合蛋白衍生的巨噬细胞激活因子 Download PDF

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CN1174097C
CN1174097C CNB961958081A CN96195808A CN1174097C CN 1174097 C CN1174097 C CN 1174097C CN B961958081 A CNB961958081 A CN B961958081A CN 96195808 A CN96195808 A CN 96195808A CN 1174097 C CN1174097 C CN 1174097C
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protein
clone
activating factor
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CN1191567A (zh
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山本信人
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
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    • G01N33/56983—Viruses
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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CNB961958081A 1995-06-07 1996-06-05 由克隆的维生素d结合蛋白衍生的巨噬细胞激活因子 Expired - Fee Related CN1174097C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/478,121 1995-06-07
US08/478,121 US5620846A (en) 1995-06-07 1995-06-07 Diagnostic and prognostic indices for cancer and aids
US08/618,485 US6410269B1 (en) 1995-06-07 1996-03-19 Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
US08/618,485 1996-03-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA031480365A Division CN1510147A (zh) 1995-06-07 1996-06-05 测定α-N-乙酰氨基半乳糖苷酶活性的方法

Publications (2)

Publication Number Publication Date
CN1191567A CN1191567A (zh) 1998-08-26
CN1174097C true CN1174097C (zh) 2004-11-03

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CNA031480365A Pending CN1510147A (zh) 1995-06-07 1996-06-05 测定α-N-乙酰氨基半乳糖苷酶活性的方法
CNB961958081A Expired - Fee Related CN1174097C (zh) 1995-06-07 1996-06-05 由克隆的维生素d结合蛋白衍生的巨噬细胞激活因子

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CNA031480365A Pending CN1510147A (zh) 1995-06-07 1996-06-05 测定α-N-乙酰氨基半乳糖苷酶活性的方法

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US (3) US6410269B1 (enExample)
EP (3) EP0837932B1 (enExample)
JP (1) JPH11511962A (enExample)
CN (2) CN1510147A (enExample)
AT (1) ATE307885T1 (enExample)
AU (1) AU6253596A (enExample)
BR (1) BR9609072A (enExample)
CA (1) CA2223940A1 (enExample)
DE (2) DE69635346D1 (enExample)
ES (1) ES2252756T3 (enExample)
NO (1) NO323155B1 (enExample)
WO (1) WO1996040903A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985545A (en) * 1996-03-19 1999-11-16 Yamamoto; Nobuto Diagnostic and prognostic ELISA assays of serum α-N-acetylgalactosaminidase for AIDS
WO2001085194A1 (en) * 2000-05-09 2001-11-15 Children's Medical Center Corporation Method and composition for the treatment of angiogenesis
US20050009120A1 (en) * 2000-09-07 2005-01-13 The Brigham And Women's Hospital, Inc. Methods of detecting ovarian cancer based on osteopontin
US6846642B2 (en) * 2000-09-07 2005-01-25 The Brigham And Women's Hospital, Inc. Methods of detecting cancer based on prostasin
EP1347953A2 (en) * 2000-11-09 2003-10-01 Northeastern Ohio Universities College of Medicine Agents and methods for promoting bone growth
US20020164664A1 (en) * 2000-11-30 2002-11-07 Matritech, Inc. Detection and treatment of prostate cancer
US7112408B2 (en) * 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US6806355B2 (en) 2001-08-14 2004-10-19 Statens Serum Institut Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product
US7288383B2 (en) * 2003-01-15 2007-10-30 The Brigham And Women's Hospital, Inc. Eosinophil-derived neurotoxin as a marker for ovarian cancer
WO2005087793A2 (en) * 2004-02-05 2005-09-22 The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Immunostimulatory compositions and uses thereof
US20050186577A1 (en) * 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
WO2006063028A2 (en) * 2004-12-07 2006-06-15 The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Immunostimulatory compositions and uses thereof
US8460697B2 (en) 2006-12-13 2013-06-11 Susavion Biosciences, Inc. Pro-angiogenic peptides and uses thereof
US8496942B2 (en) 2006-12-13 2013-07-30 Susavion Biosciences, Inc. Therapeutic peptides and uses thereof
US7811995B2 (en) 2006-12-13 2010-10-12 Susavion Biosciences, Inc. Therapeutic and diagnostic peptides
USRE46425E1 (en) 2006-12-13 2017-06-06 Susavion Biosciences, Inc. Pro-angiogenic peptides and uses thereof
US7838497B2 (en) 2006-12-13 2010-11-23 Susavion Biosciences, Inc. Pro-angiogenic peptides
US20110123591A1 (en) * 2009-08-22 2011-05-26 Charles Knezevich Tumoricidal, bactericidal, or viricidal macrophage activation
WO2012029954A1 (ja) 2010-09-03 2012-03-08 国立大学法人徳島大学 新規Ｇｃグロブリンガラクトース脱糖体の製造方法
EP2694088B1 (en) * 2011-04-07 2017-06-07 Efranat Ltd. Macrophage activating factor for pharmaceutical compositions
EP2561879A1 (en) 2011-08-23 2013-02-27 Protea Biopharma N.V. Macrophage activating factor for use in the treatment of chronic fatigue syndrome (CFS) and CFS-related diseases and disorders
WO2013130953A2 (en) * 2012-03-01 2013-09-06 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof
EP2687264A1 (en) 2012-07-17 2014-01-22 Protea Biopharma N.V. Macrophage Activating Factor for treatment of endometriosis
AU2014207429B2 (en) * 2013-01-18 2018-11-01 Ellis KLINE Selective glycosidase regimen for immune programming and treatment of cancer
CN105530950A (zh) * 2013-06-09 2016-04-27 艾弗兰纳特有限公司 包含Gc-巨噬细胞活化因子的组合物及其用途
AT518622A1 (de) * 2016-04-21 2017-11-15 Hg Pharma Gmbh Dimerer Komplex aus selektiv deglycosyliertem Vitamin D bindenden Protein (GcMAF) und Cholecalciferol (Calciol) und Verfahren zu dessen Herstellung
WO2019117295A1 (ja) * 2017-12-15 2019-06-20 公益財団法人神戸医療産業都市推進機構 活性型ＧｃＭＡＦの製造方法
EP4260866A4 (en) 2020-12-08 2025-01-01 Saisei Pharma Co., Ltd. MACROPHAGE ACTIVATOR
CN118325844B (zh) * 2023-09-07 2025-01-03 武汉奥科博泰生物科技有限公司 识别N-乙酰-β-D-氨基葡萄糖苷酶的单克隆抗体及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177001A (en) 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated mammalian vitamin D-binding protein to a potent macrophage activating factor
US5177002A (en) * 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated human vitamin D binding protein to a potent macrophage activating factor
US5326749A (en) 1989-11-20 1994-07-05 Nobuto Yamamoto Macrophage activating factor from vitamin D binding protein
US5516657A (en) * 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins
US5652352A (en) * 1994-03-31 1997-07-29 Amgen Inc. Afamin: a human serum albumin-like gene

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EP1443112A3 (en) 2004-11-03
EP1340815A3 (en) 2003-09-17
CA2223940A1 (en) 1996-12-19
AU6253596A (en) 1996-12-30
DE69635346T2 (de) 2006-07-27
ATE307885T1 (de) 2005-11-15
US20020055140A1 (en) 2002-05-09
EP0837932A4 (en) 2001-02-28
WO1996040903A1 (en) 1996-12-19
CN1510147A (zh) 2004-07-07
EP0837932B1 (en) 2005-10-26
CN1191567A (zh) 1998-08-26
NO975771D0 (no) 1997-12-08
JPH11511962A (ja) 1999-10-19
BR9609072A (pt) 2000-10-24
DE69635346D1 (de) 2005-12-01
ES2252756T3 (es) 2006-05-16
NO975771L (no) 1998-01-30
DE69635346T4 (de) 2007-11-08
EP1443112A2 (en) 2004-08-04
EP1340815A2 (en) 2003-09-03
US6410269B1 (en) 2002-06-25
EP0837932A1 (en) 1998-04-29
NO323155B1 (no) 2007-01-08
US5712104A (en) 1998-01-27

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