CA2221605C - Methods and devices for the removal of psoralens from blood products - Google Patents

Methods and devices for the removal of psoralens from blood products Download PDF

Info

Publication number
CA2221605C
CA2221605C CA002221605A CA2221605A CA2221605C CA 2221605 C CA2221605 C CA 2221605C CA 002221605 A CA002221605 A CA 002221605A CA 2221605 A CA2221605 A CA 2221605A CA 2221605 C CA2221605 C CA 2221605C
Authority
CA
Canada
Prior art keywords
psoralen
blood
resin
container
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002221605A
Other languages
English (en)
French (fr)
Other versions
CA2221605A1 (en
Inventor
Derek J. Hei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerus Corp
Original Assignee
Cerus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp filed Critical Cerus Corp
Priority claimed from US08/659,249 external-priority patent/US6544727B1/en
Publication of CA2221605A1 publication Critical patent/CA2221605A1/en
Application granted granted Critical
Publication of CA2221605C publication Critical patent/CA2221605C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/12Layered products comprising a layer of synthetic resin next to a fibrous or filamentary layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/19Platelets; Megacaryocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029Radiation
    • A61L2/0035Gamma radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A61M1/3686Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents by removing photoactive agents after irradiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/36Layered products comprising a layer of synthetic resin comprising polyesters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/02Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
    • B32B5/028Net structure, e.g. spaced apart filaments bonded at the crossing points
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2367/00Polyesters, e.g. PET, i.e. polyethylene terephthalate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00Containers; Receptacles
    • B32B2439/80Medical packaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • External Artificial Organs (AREA)
  • Compounds Of Unknown Constitution (AREA)
CA002221605A 1995-06-07 1996-06-07 Methods and devices for the removal of psoralens from blood products Expired - Fee Related CA2221605C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US48492695A 1995-06-07 1995-06-07
US08/484,926 1995-06-07
US66091096A 1996-06-07 1996-06-07
US08/659,249 US6544727B1 (en) 1995-06-07 1996-06-07 Methods and devices for the removal of psoralens from blood products
US08/660,910 1996-06-07
PCT/US1996/009846 WO1996040857A1 (en) 1995-06-07 1996-06-07 Methods and devices for the removal of psoralens from blood products
US08/659,249 1996-06-07

Publications (2)

Publication Number Publication Date
CA2221605A1 CA2221605A1 (en) 1996-12-19
CA2221605C true CA2221605C (en) 2005-10-18

Family

ID=29740870

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221605A Expired - Fee Related CA2221605C (en) 1995-06-07 1996-06-07 Methods and devices for the removal of psoralens from blood products

Country Status (8)

Country Link
EP (1) EP0840781B1 (enExample)
JP (1) JP4968974B2 (enExample)
AT (1) ATE451445T1 (enExample)
AU (1) AU6267796A (enExample)
CA (1) CA2221605C (enExample)
DE (1) DE69638094D1 (enExample)
ES (1) ES2337852T3 (enExample)
WO (1) WO1996040857A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009051846A (ja) * 1995-06-07 2009-03-12 Cerus Corp 血液製剤からソラレンを除去するための方法およびデバイス
AU722811B2 (en) * 1995-06-07 2000-08-10 Cerus Corporation Treating red blood cell solutions with anti-viral agents
DE19544297A1 (de) * 1995-11-28 1997-06-05 Behringwerke Ag Verfahren zur Entfernung von aromatischen Verbindungen aus produkthaltigen Lösungen
WO1997037536A1 (en) * 1996-04-09 1997-10-16 Therakos, Inc. Method for removal of psoralens from biological fluids
US6514987B1 (en) 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
AU6021698A (en) * 1997-01-06 1998-08-03 Cerus Corporation Methods and devices for the reduction of small organic compounds from bloo d products
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
CN1203900C (zh) 1998-01-06 2005-06-01 塞鲁斯公司 用于淬灭生物材料中病原体灭活剂的方法
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6403359B1 (en) 1998-09-25 2002-06-11 V. I. TECHNOLOGIES, Inc. Solid phase quenching systems
US6617100B2 (en) * 1998-09-25 2003-09-09 V.I. Technologies, Inc. Solid phase quenching systems
US6565802B1 (en) 1999-06-03 2003-05-20 Baxter International Inc. Apparatus, systems and methods for processing and treating a biological fluid with light
US7025877B1 (en) 1999-06-03 2006-04-11 Baxter International Inc. Processing set for processing and treating a biological fluid
US6364864B1 (en) 1999-06-03 2002-04-02 Baxter International Inc. Plastic containers having inner pouches and methods for making such containers
US7068361B2 (en) 1999-06-03 2006-06-27 Baxter International Apparatus, systems and methods for processing and treating a biological fluid with light
US7445756B2 (en) * 1999-06-03 2008-11-04 Fenwal, Inc. Fluid processing sets and organizers for the same
CA2572327A1 (en) * 2004-06-29 2006-02-02 Reliance Life Sciences Pvt. Ltd. Process for the preparation of virus-safe biological fluids
CA2585621C (en) 2004-10-29 2015-12-15 Cerus Corporation Improved quenching methods for red blood cell inactivation process
HUE029958T2 (en) 2005-12-13 2017-04-28 Exthera Medical Corp A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body
US7802796B2 (en) 2006-01-05 2010-09-28 Saint-Gobain Performance Plastics Corporation Composite material and seals formed thereof
WO2007082111A1 (en) 2006-01-05 2007-07-19 Saint-Gobain Performance Plastics Corporation Annular seal and pump including same
KR101896430B1 (ko) 2008-04-09 2018-09-10 세루스 코포레이션 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법
DE202008012267U1 (de) * 2008-09-16 2009-02-05 KBD Gesellschaft für Unternehmensberatung, Marketing und Vertrieb mbH i. Gr. Vorrichtung zum visuellen Erkennen der Verteilung von lumineszierenden Substanzen
EP2358790B2 (en) 2008-12-16 2016-09-21 Dow Corning Corporation Preparation of siloxanes
CN102245943A (zh) 2008-12-24 2011-11-16 美国圣戈班性能塑料公司 用于高压泵应用的聚合物材料及其形成的密封件
US11864553B2 (en) 2009-10-23 2024-01-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
JP5925693B2 (ja) 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
US20140158604A1 (en) * 2012-12-12 2014-06-12 Jacques Chammas Platelet Storage Container
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
KR101894762B1 (ko) 2013-07-12 2018-09-05 이엠디 밀리포어 코포레이션 표적 단백질을 함유하는 샘플로부터 활성탄을 사용하여 바이러스 제거를 결정하는 방법
JP6806563B2 (ja) 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
KR20170020749A (ko) 2014-04-24 2017-02-24 엑스테라 메디컬 코퍼레이션 고유속을 이용한 혈액으로부터 세균의 제거방법
CN107075478B (zh) 2014-07-23 2021-11-09 塞鲁斯公司 制备血小板制品的方法
JP7100454B2 (ja) 2014-09-22 2022-07-13 エクスセラ メディカル コーポレイション 装着型血液潅流デバイス
US20170304363A1 (en) 2014-10-10 2017-10-26 Cerus Corporation Compositions and methods for treating viral hemorrhagic fever
EA201890149A1 (ru) 2015-06-26 2018-07-31 Сирус Корпорейшн Композиции криопреципитатов и способы их получения
US20170028121A1 (en) * 2015-07-31 2017-02-02 Fenwal, Inc. Irradiation device for biological fluids
US10799533B2 (en) 2015-10-23 2020-10-13 Cerus Corporation Plasma compositions and methods of use thereof
EP3399986B1 (en) 2016-01-07 2023-02-22 Cerus Corporation Systems and methods for preparation of platelets
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
BR112019018273A2 (pt) 2017-03-03 2020-07-14 Cerus Corporation kits e métodos para preparação de composições de plaquetas inativadas por patógenos
SG11202002438TA (en) 2017-09-20 2020-04-29 Cerus Corp Compositions and methods for pathogen inactivation of platelets
TWI821233B (zh) 2017-12-29 2023-11-11 美商西勒斯股份有限公司 用於處理生物流體之方法、藉由該方法製備之病原體去活生物流體、及用於處理生物流體之系統
KR20220009400A (ko) 2019-05-16 2022-01-24 엑스테라 메디컬 코퍼레이션 내피 글리코칼릭스 구조의 조절 방법
CA3143213A1 (en) 2019-06-22 2020-12-30 Cerus Corporation Biological fluid treatment systems
WO2020264421A1 (en) 2019-06-28 2020-12-30 Cerus Corporation System and methods for implementing a biological fluid treatment device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756082A (fr) * 1969-09-12 1971-03-11 I Elementoorganiche Kih Soedin Squelettes macroreticulaires de polystyrene pour resines echangeuses d'ions et leur procede de preparation (
US4748120A (en) * 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
DE3819000A1 (de) * 1988-06-03 1989-12-14 Hasso Von Bluecher Beutel in der art eines teebeutels zur beseitigung von schadstoffen
US5094960A (en) * 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
US5418130A (en) * 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US5176634A (en) * 1990-08-02 1993-01-05 Mcgaw, Inc. Flexible multiple compartment drug container
US5209347A (en) * 1990-12-05 1993-05-11 Clintec Nutrition Company Internal tear seal dual bag
US5128048A (en) * 1991-05-22 1992-07-07 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
JPH09500015A (ja) * 1993-06-23 1997-01-07 ニューヨーク ブラッド センター,インコーポレイティド 血液のウィルス不活性化のためのシステム
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US6319662B1 (en) * 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid

Also Published As

Publication number Publication date
EP0840781B1 (en) 2009-12-09
CA2221605A1 (en) 1996-12-19
WO1996040857A1 (en) 1996-12-19
ATE451445T1 (de) 2009-12-15
EP0840781A1 (en) 1998-05-13
JP2002509518A (ja) 2002-03-26
EP0840781A4 (en) 2001-03-21
AU6267796A (en) 1996-12-30
JP4968974B2 (ja) 2012-07-04
DE69638094D1 (de) 2010-01-21
ES2337852T3 (es) 2010-04-29

Similar Documents

Publication Publication Date Title
CA2221605C (en) Methods and devices for the removal of psoralens from blood products
US6544727B1 (en) Methods and devices for the removal of psoralens from blood products
US20020192632A1 (en) Method and devices for the removal of psoralens from blood products
JP2002509518A5 (enExample)
US20020115585A1 (en) Method and devices for the removal of psoralens from blood products
AU722811B2 (en) Treating red blood cell solutions with anti-viral agents
US5593823A (en) Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens
US7037642B2 (en) Removing compounds from blood products with porous particles immobilized in a matrix
US9259525B2 (en) Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
CA2165984C (en) Compounds for the photodecontamination of pathogens in blood
US5871900A (en) Method of inactivating pathogens in biological fluids using photoactivated 5-primaryamino psoralens
US6194139B1 (en) Methods for photodecontamination of pathogens in blood
EP0954374B1 (en) Adsorbens and devices for the reduction of small organic compounds from blood products
AU759966C (en) Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
Horowitz et al. Efforts in minimizing risk of viral transmission through viral inactivation
AU757224B2 (en) Method and devices for the removal of psoralens from blood products
JP2012067126A (ja) 血液製剤からソラレンを除去するための方法およびデバイス
JP2009051846A (ja) 血液製剤からソラレンを除去するための方法およびデバイス
AU7153800A (en) Treating red blood cell solutions with anti-viral agents

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160607