DE69638094D1 - Verfahren und vorrichtungen zur entfernung von psoralenen aus blutprodukten. - Google Patents
Verfahren und vorrichtungen zur entfernung von psoralenen aus blutprodukten.Info
- Publication number
- DE69638094D1 DE69638094D1 DE69638094T DE69638094T DE69638094D1 DE 69638094 D1 DE69638094 D1 DE 69638094D1 DE 69638094 T DE69638094 T DE 69638094T DE 69638094 T DE69638094 T DE 69638094T DE 69638094 D1 DE69638094 D1 DE 69638094D1
- Authority
- DE
- Germany
- Prior art keywords
- devices
- blood products
- methods
- psoralen
- psorals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 8
- 239000010836 blood and blood product Substances 0.000 title abstract 4
- 229940125691 blood product Drugs 0.000 title abstract 4
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 abstract 4
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 238000002617 apheresis Methods 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000003634 thrombocyte concentrate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/12—Layered products comprising a layer of synthetic resin next to a fibrous or filamentary layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
- A61M1/3686—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents by removing photoactive agents after irradiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
- B32B5/028—Net structure, e.g. spaced apart filaments bonded at the crossing points
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2367/00—Polyesters, e.g. PET, i.e. polyethylene terephthalate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- External Artificial Organs (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48492695A | 1995-06-07 | 1995-06-07 | |
| US66091096A | 1996-06-07 | 1996-06-07 | |
| US08/659,249 US6544727B1 (en) | 1995-06-07 | 1996-06-07 | Methods and devices for the removal of psoralens from blood products |
| PCT/US1996/009846 WO1996040857A1 (en) | 1995-06-07 | 1996-06-07 | Methods and devices for the removal of psoralens from blood products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69638094D1 true DE69638094D1 (de) | 2010-01-21 |
Family
ID=29740870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69638094T Expired - Lifetime DE69638094D1 (de) | 1995-06-07 | 1996-06-07 | Verfahren und vorrichtungen zur entfernung von psoralenen aus blutprodukten. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0840781B1 (enExample) |
| JP (1) | JP4968974B2 (enExample) |
| AT (1) | ATE451445T1 (enExample) |
| AU (1) | AU6267796A (enExample) |
| CA (1) | CA2221605C (enExample) |
| DE (1) | DE69638094D1 (enExample) |
| ES (1) | ES2337852T3 (enExample) |
| WO (1) | WO1996040857A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009051846A (ja) * | 1995-06-07 | 2009-03-12 | Cerus Corp | 血液製剤からソラレンを除去するための方法およびデバイス |
| AU722811B2 (en) * | 1995-06-07 | 2000-08-10 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
| DE19544297A1 (de) * | 1995-11-28 | 1997-06-05 | Behringwerke Ag | Verfahren zur Entfernung von aromatischen Verbindungen aus produkthaltigen Lösungen |
| WO1997037536A1 (en) * | 1996-04-09 | 1997-10-16 | Therakos, Inc. | Method for removal of psoralens from biological fluids |
| US6514987B1 (en) | 1997-01-06 | 2003-02-04 | Cerus Corporation | Frangible compounds for pathogen inactivation |
| US20010009756A1 (en) | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
| US20010018179A1 (en) | 1998-01-06 | 2001-08-30 | Derek J. Hei | Batch devices for the reduction of compounds from biological compositions containing cells and methods of use |
| AU6021698A (en) * | 1997-01-06 | 1998-08-03 | Cerus Corporation | Methods and devices for the reduction of small organic compounds from bloo d products |
| US6093725A (en) * | 1997-01-06 | 2000-07-25 | Cerus Corporation | Frangible compounds for pathogen inactivation |
| CN1203900C (zh) | 1998-01-06 | 2005-06-01 | 塞鲁斯公司 | 用于淬灭生物材料中病原体灭活剂的方法 |
| US7611831B2 (en) | 1998-01-06 | 2009-11-03 | Cerus Corporation | Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix |
| US6403359B1 (en) | 1998-09-25 | 2002-06-11 | V. I. TECHNOLOGIES, Inc. | Solid phase quenching systems |
| US6617100B2 (en) * | 1998-09-25 | 2003-09-09 | V.I. Technologies, Inc. | Solid phase quenching systems |
| US6565802B1 (en) | 1999-06-03 | 2003-05-20 | Baxter International Inc. | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US7025877B1 (en) | 1999-06-03 | 2006-04-11 | Baxter International Inc. | Processing set for processing and treating a biological fluid |
| US6364864B1 (en) | 1999-06-03 | 2002-04-02 | Baxter International Inc. | Plastic containers having inner pouches and methods for making such containers |
| US7068361B2 (en) | 1999-06-03 | 2006-06-27 | Baxter International | Apparatus, systems and methods for processing and treating a biological fluid with light |
| US7445756B2 (en) * | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
| CA2572327A1 (en) * | 2004-06-29 | 2006-02-02 | Reliance Life Sciences Pvt. Ltd. | Process for the preparation of virus-safe biological fluids |
| CA2585621C (en) | 2004-10-29 | 2015-12-15 | Cerus Corporation | Improved quenching methods for red blood cell inactivation process |
| HUE029958T2 (en) | 2005-12-13 | 2017-04-28 | Exthera Medical Corp | A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body |
| US7802796B2 (en) | 2006-01-05 | 2010-09-28 | Saint-Gobain Performance Plastics Corporation | Composite material and seals formed thereof |
| WO2007082111A1 (en) | 2006-01-05 | 2007-07-19 | Saint-Gobain Performance Plastics Corporation | Annular seal and pump including same |
| KR101896430B1 (ko) | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
| DE202008012267U1 (de) * | 2008-09-16 | 2009-02-05 | KBD Gesellschaft für Unternehmensberatung, Marketing und Vertrieb mbH i. Gr. | Vorrichtung zum visuellen Erkennen der Verteilung von lumineszierenden Substanzen |
| EP2358790B2 (en) | 2008-12-16 | 2016-09-21 | Dow Corning Corporation | Preparation of siloxanes |
| CN102245943A (zh) | 2008-12-24 | 2011-11-16 | 美国圣戈班性能塑料公司 | 用于高压泵应用的聚合物材料及其形成的密封件 |
| US11864553B2 (en) | 2009-10-23 | 2024-01-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| JP5925693B2 (ja) | 2009-12-01 | 2016-05-25 | エクステラ・メディカル・コーポレーション | 表面固定した多糖類を用いた、血液からのサイトカイン除去法 |
| WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
| DK2861273T3 (da) | 2012-06-13 | 2017-11-27 | Exthera Medical Corp | Anvendelse af heparin og kulhydrater til behandling af cancer. |
| US9414752B2 (en) | 2012-11-09 | 2016-08-16 | Elwha Llc | Embolism deflector |
| US20140158604A1 (en) * | 2012-12-12 | 2014-06-12 | Jacques Chammas | Platelet Storage Container |
| EP3013445B1 (en) | 2013-06-24 | 2019-11-06 | ExThera Medical Corporation | Blood filtration system containing mannose coated substrate |
| KR101894762B1 (ko) | 2013-07-12 | 2018-09-05 | 이엠디 밀리포어 코포레이션 | 표적 단백질을 함유하는 샘플로부터 활성탄을 사용하여 바이러스 제거를 결정하는 방법 |
| JP6806563B2 (ja) | 2013-11-08 | 2021-01-06 | エクステラ・メディカル・コーポレーション | 吸着媒体を使用する感染症の診断法 |
| KR20170020749A (ko) | 2014-04-24 | 2017-02-24 | 엑스테라 메디컬 코퍼레이션 | 고유속을 이용한 혈액으로부터 세균의 제거방법 |
| CN107075478B (zh) | 2014-07-23 | 2021-11-09 | 塞鲁斯公司 | 制备血小板制品的方法 |
| JP7100454B2 (ja) | 2014-09-22 | 2022-07-13 | エクスセラ メディカル コーポレイション | 装着型血液潅流デバイス |
| US20170304363A1 (en) | 2014-10-10 | 2017-10-26 | Cerus Corporation | Compositions and methods for treating viral hemorrhagic fever |
| EA201890149A1 (ru) | 2015-06-26 | 2018-07-31 | Сирус Корпорейшн | Композиции криопреципитатов и способы их получения |
| US20170028121A1 (en) * | 2015-07-31 | 2017-02-02 | Fenwal, Inc. | Irradiation device for biological fluids |
| US10799533B2 (en) | 2015-10-23 | 2020-10-13 | Cerus Corporation | Plasma compositions and methods of use thereof |
| EP3399986B1 (en) | 2016-01-07 | 2023-02-22 | Cerus Corporation | Systems and methods for preparation of platelets |
| US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
| WO2017151797A1 (en) | 2016-03-02 | 2017-09-08 | Exthera Medical Corporation | Method for treating drug intoxication |
| BR112019018273A2 (pt) | 2017-03-03 | 2020-07-14 | Cerus Corporation | kits e métodos para preparação de composições de plaquetas inativadas por patógenos |
| SG11202002438TA (en) | 2017-09-20 | 2020-04-29 | Cerus Corp | Compositions and methods for pathogen inactivation of platelets |
| TWI821233B (zh) | 2017-12-29 | 2023-11-11 | 美商西勒斯股份有限公司 | 用於處理生物流體之方法、藉由該方法製備之病原體去活生物流體、及用於處理生物流體之系統 |
| KR20220009400A (ko) | 2019-05-16 | 2022-01-24 | 엑스테라 메디컬 코퍼레이션 | 내피 글리코칼릭스 구조의 조절 방법 |
| CA3143213A1 (en) | 2019-06-22 | 2020-12-30 | Cerus Corporation | Biological fluid treatment systems |
| WO2020264421A1 (en) | 2019-06-28 | 2020-12-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756082A (fr) * | 1969-09-12 | 1971-03-11 | I Elementoorganiche Kih Soedin | Squelettes macroreticulaires de polystyrene pour resines echangeuses d'ions et leur procede de preparation ( |
| US4748120A (en) * | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
| DE3819000A1 (de) * | 1988-06-03 | 1989-12-14 | Hasso Von Bluecher | Beutel in der art eines teebeutels zur beseitigung von schadstoffen |
| US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
| US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
| US5176634A (en) * | 1990-08-02 | 1993-01-05 | Mcgaw, Inc. | Flexible multiple compartment drug container |
| US5209347A (en) * | 1990-12-05 | 1993-05-11 | Clintec Nutrition Company | Internal tear seal dual bag |
| US5128048A (en) * | 1991-05-22 | 1992-07-07 | Baxter International Inc. | Systems and methods for removing undesired matter from blood cells |
| JPH09500015A (ja) * | 1993-06-23 | 1997-01-07 | ニューヨーク ブラッド センター,インコーポレイティド | 血液のウィルス不活性化のためのシステム |
| US5399719A (en) * | 1993-06-28 | 1995-03-21 | Steritech, Inc. | Compounds for the photodecontamination of pathogens in blood |
| US6319662B1 (en) * | 1993-12-17 | 2001-11-20 | Baxter International Inc. | Method and apparatus for removing viral contaminants from a body fluid |
-
1996
- 1996-06-07 EP EP96921456A patent/EP0840781B1/en not_active Expired - Lifetime
- 1996-06-07 WO PCT/US1996/009846 patent/WO1996040857A1/en not_active Ceased
- 1996-06-07 CA CA002221605A patent/CA2221605C/en not_active Expired - Fee Related
- 1996-06-07 JP JP50204597A patent/JP4968974B2/ja not_active Expired - Lifetime
- 1996-06-07 DE DE69638094T patent/DE69638094D1/de not_active Expired - Lifetime
- 1996-06-07 AT AT96921456T patent/ATE451445T1/de not_active IP Right Cessation
- 1996-06-07 ES ES96921456T patent/ES2337852T3/es not_active Expired - Lifetime
- 1996-06-07 AU AU62677/96A patent/AU6267796A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0840781B1 (en) | 2009-12-09 |
| CA2221605A1 (en) | 1996-12-19 |
| WO1996040857A1 (en) | 1996-12-19 |
| ATE451445T1 (de) | 2009-12-15 |
| EP0840781A1 (en) | 1998-05-13 |
| CA2221605C (en) | 2005-10-18 |
| JP2002509518A (ja) | 2002-03-26 |
| EP0840781A4 (en) | 2001-03-21 |
| AU6267796A (en) | 1996-12-30 |
| JP4968974B2 (ja) | 2012-07-04 |
| ES2337852T3 (es) | 2010-04-29 |
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