CA2218225A1 - Peptide-2 analogue au glucagon et ses utilisations therapeutiques - Google Patents
Peptide-2 analogue au glucagon et ses utilisations therapeutiquesInfo
- Publication number
- CA2218225A1 CA2218225A1 CA002218225A CA2218225A CA2218225A1 CA 2218225 A1 CA2218225 A1 CA 2218225A1 CA 002218225 A CA002218225 A CA 002218225A CA 2218225 A CA2218225 A CA 2218225A CA 2218225 A1 CA2218225 A1 CA 2218225A1
- Authority
- CA
- Canada
- Prior art keywords
- glp
- peptide
- asp
- analog
- ile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/605—Glucagons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Obesity (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
Abstract
Un peptide-2 analogue au glucagon, un produit de l'expression génique du glucagon et les analogues de ce peptide-2 ont été identifiés comme facteurs de croissance du tissu gastro-intestinal. Leurs effets sur la croissance de l'intestin grêle et des îlots pancréatiques, ainsi que leur formulation en produit pharmaceutique et leur utilisation thérapeutique dans le traitement des troubles de l'intestin sont également décrits.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/422,540 US5990077A (en) | 1995-04-14 | 1995-04-14 | Glucagon-like peptide-2 and its therapeutic use |
US08/422,540 | 1995-04-14 | ||
PCT/CA1996/000232 WO1996032414A1 (fr) | 1995-04-14 | 1996-04-12 | Peptide-2 analogue au glucagon et ses utilisations therapeutiques |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2218225A1 true CA2218225A1 (fr) | 1996-10-17 |
CA2218225C CA2218225C (fr) | 2014-09-23 |
Family
ID=23675346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2218225A Expired - Lifetime CA2218225C (fr) | 1995-04-14 | 1996-04-12 | Peptide-2 analogue au glucagon et ses utilisations therapeutiques |
Country Status (13)
Country | Link |
---|---|
US (1) | US5990077A (fr) |
EP (4) | EP0830377B2 (fr) |
JP (3) | JPH11505521A (fr) |
CN (2) | CN101254300B (fr) |
AT (1) | ATE445641T1 (fr) |
AU (1) | AU720493B2 (fr) |
CA (1) | CA2218225C (fr) |
CY (1) | CY2615B2 (fr) |
DE (1) | DE69638057D1 (fr) |
DK (1) | DK0830377T4 (fr) |
ES (1) | ES2334864T5 (fr) |
PT (1) | PT830377E (fr) |
WO (1) | WO1996032414A1 (fr) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834428A (en) * | 1995-04-14 | 1998-11-10 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
US5990077A (en) | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
US6184201B1 (en) | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
US5912229A (en) * | 1996-03-01 | 1999-06-15 | Novo Nordisk Als | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
AU710818B2 (en) * | 1996-03-01 | 1999-09-30 | Novo Nordisk A/S | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
AU733857B2 (en) * | 1996-04-12 | 2001-05-31 | 1149336 Ontario Inc. | Glucagon-like peptide-2 analogs |
AU753771B2 (en) * | 1996-04-12 | 2002-10-31 | 1149336 Ontario Inc. | Glucagon-like peptide-2 analogs |
US5994500A (en) * | 1996-07-19 | 1999-11-30 | 1149336 Ontario Inc. | Antagonists of intestinotrophic GLP-2 peptides |
US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
EP0929576A1 (fr) * | 1996-08-30 | 1999-07-21 | Novo Nordisk A/S | Derives de glp-2 |
US5952301A (en) * | 1996-12-10 | 1999-09-14 | 1149336 Ontario Inc. | Compositions and methods for enhancing intestinal function |
EP0946591B1 (fr) * | 1996-12-13 | 2007-04-04 | Allelix Biopharmaceuticals Inc. | Recepteurs clones de peptides-2 semblables au glucagon |
US8592553B2 (en) | 1996-12-13 | 2013-11-26 | Nps Pharmaceuticals, Inc. | Cloned glucagon-like peptide-2 receptors |
CA2236519C (fr) | 1997-05-02 | 2011-09-13 | 1149336 Ontario Inc. | Methodes pour ameliorer le fonctionnement du gros intestin |
DK0981362T3 (da) * | 1997-05-16 | 2004-03-15 | Ontario Inc 1149336 | Anvendelse af GLP-2-agonister, der forbedrer funktionen af den øvre mavetarmkanal |
WO1999043361A1 (fr) * | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Derives de glp-2 avec teneur en structures en helices superieure a 25 %, formant des agregats de type micellaire partiellement structures |
US6444788B1 (en) | 1999-03-15 | 2002-09-03 | Novo Nordisk A/S | Ion exchange chromatography of GLP-1, analogs and derivatives thereof |
EP2348044A1 (fr) | 1999-03-15 | 2011-07-27 | Novo Nordisk A/S | Chromatographie d'échange d'ions de GLP-1, analogues et dérivés associés |
US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
WO2002022151A2 (fr) | 2000-09-18 | 2002-03-21 | Osteometer Bio Tech A/S | Utilisation de peptides glp-1 et glp-2 |
US20070135345A1 (en) * | 2000-09-18 | 2007-06-14 | Henriksen Dennis B | Use of GLP-2 for the treatment or prevention, of bone-related disorders |
US7186683B2 (en) | 2000-09-18 | 2007-03-06 | Sanos Bioscience A/S | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders |
US7371721B2 (en) * | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
US20080249016A1 (en) * | 2000-09-18 | 2008-10-09 | Sanos Bioscience A/S | Use of GLP-2 in a combination treatment for bone-related disorders |
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AU2002233089B2 (en) | 2001-02-16 | 2005-12-22 | Conjuchem Biotechnologies Inc. | Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders |
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BR9306551A (pt) * | 1992-06-15 | 1998-09-15 | Pfizer | Derivados de peptídeo do tipo glucagona e de insulinotropina |
JP2961045B2 (ja) * | 1993-02-24 | 1999-10-12 | 日清製粉株式会社 | 腸管粘膜増強促進剤 |
US5990077A (en) | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
AU710818B2 (en) | 1996-03-01 | 1999-09-30 | Novo Nordisk A/S | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
AU733857B2 (en) * | 1996-04-12 | 2001-05-31 | 1149336 Ontario Inc. | Glucagon-like peptide-2 analogs |
-
1995
- 1995-04-14 US US08/422,540 patent/US5990077A/en not_active Expired - Lifetime
-
1996
- 1996-04-12 AU AU52658/96A patent/AU720493B2/en not_active Expired
- 1996-04-12 ES ES96908973T patent/ES2334864T5/es not_active Expired - Lifetime
- 1996-04-12 EP EP96908973A patent/EP0830377B2/fr not_active Expired - Lifetime
- 1996-04-12 CA CA2218225A patent/CA2218225C/fr not_active Expired - Lifetime
- 1996-04-12 CN CN2008100012906A patent/CN101254300B/zh not_active Expired - Lifetime
- 1996-04-12 JP JP8530606A patent/JPH11505521A/ja not_active Withdrawn
- 1996-04-12 CN CNB961946938A patent/CN100374461C/zh not_active Expired - Lifetime
- 1996-04-12 EP EP10012215A patent/EP2277530A1/fr not_active Withdrawn
- 1996-04-12 DE DE69638057T patent/DE69638057D1/de not_active Expired - Lifetime
- 1996-04-12 DK DK96908973.9T patent/DK0830377T4/da active
- 1996-04-12 EP EP10012214A patent/EP2277909A1/fr not_active Withdrawn
- 1996-04-12 PT PT96908973T patent/PT830377E/pt unknown
- 1996-04-12 AT AT96908973T patent/ATE445641T1/de active
- 1996-04-12 WO PCT/CA1996/000232 patent/WO1996032414A1/fr active Application Filing
- 1996-04-12 EP EP08154372.0A patent/EP1988100B1/fr not_active Expired - Lifetime
-
2006
- 2006-07-05 JP JP2006185610A patent/JP4496183B2/ja not_active Expired - Lifetime
-
2010
- 2010-01-25 JP JP2010012787A patent/JP5281594B2/ja not_active Expired - Lifetime
-
2011
- 2011-04-15 CY CY1100004A patent/CY2615B2/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP4496183B2 (ja) | 2010-07-07 |
AU5265896A (en) | 1996-10-30 |
EP0830377A1 (fr) | 1998-03-25 |
CY2615B2 (en) | 2012-01-25 |
JP2010159259A (ja) | 2010-07-22 |
EP2277909A1 (fr) | 2011-01-26 |
JP5281594B2 (ja) | 2013-09-04 |
CN101254300B (zh) | 2013-05-08 |
CN100374461C (zh) | 2008-03-12 |
EP1988100B1 (fr) | 2015-03-04 |
ES2334864T5 (es) | 2013-04-08 |
WO1996032414A1 (fr) | 1996-10-17 |
EP0830377B1 (fr) | 2009-10-14 |
JPH11505521A (ja) | 1999-05-21 |
US5990077A (en) | 1999-11-23 |
EP0830377B2 (fr) | 2012-12-12 |
DE69638057D1 (de) | 2009-11-26 |
ATE445641T1 (de) | 2009-10-15 |
JP2006342172A (ja) | 2006-12-21 |
DK0830377T3 (da) | 2010-03-01 |
CN101254300A (zh) | 2008-09-03 |
ES2334864T3 (es) | 2010-03-16 |
CN1188485A (zh) | 1998-07-22 |
DK0830377T4 (da) | 2013-03-11 |
AU720493B2 (en) | 2000-06-01 |
PT830377E (pt) | 2010-01-19 |
CA2218225C (fr) | 2014-09-23 |
EP1988100A1 (fr) | 2008-11-05 |
MX9707949A (es) | 1998-06-30 |
EP2277530A1 (fr) | 2011-01-26 |
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