CA2212237A1 - Novel antineoplastic agents - Google Patents

Novel antineoplastic agents

Info

Publication number
CA2212237A1
CA2212237A1 CA002212237A CA2212237A CA2212237A1 CA 2212237 A1 CA2212237 A1 CA 2212237A1 CA 002212237 A CA002212237 A CA 002212237A CA 2212237 A CA2212237 A CA 2212237A CA 2212237 A1 CA2212237 A1 CA 2212237A1
Authority
CA
Canada
Prior art keywords
hydrogen
aralkyl
cycloalkyl
aryl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002212237A
Other languages
English (en)
French (fr)
Inventor
John M. Webster
Jianxiong Li
Genhui Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002212237A priority Critical patent/CA2212237A1/en
Priority to PCT/CA1998/000841 priority patent/WO1999012543A1/en
Priority to EP98942414A priority patent/EP1009401A1/en
Priority to AU90570/98A priority patent/AU759990B2/en
Priority to CN98810328A priority patent/CN1276723A/zh
Priority to JP2000510440A priority patent/JP2001515861A/ja
Publication of CA2212237A1 publication Critical patent/CA2212237A1/en
Priority to CN01131401A priority patent/CN1360891A/zh
Priority to HK02107990.3A priority patent/HK1046373A1/zh
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002212237A 1997-09-05 1997-09-05 Novel antineoplastic agents Abandoned CA2212237A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002212237A CA2212237A1 (en) 1997-09-05 1997-09-05 Novel antineoplastic agents
PCT/CA1998/000841 WO1999012543A1 (en) 1997-09-05 1998-09-03 Dithiolopyrrolones and their corresponding monoxides and dioxides as antineoplastic agents
EP98942414A EP1009401A1 (en) 1997-09-05 1998-09-03 Dithiolopyrrolones and their corresponding monoxides and dioxides as antineoplastic agents
AU90570/98A AU759990B2 (en) 1997-09-05 1998-09-03 Dithiolopyrrolones and their corresponding monoxides and dioxides as antineoplastic agents
CN98810328A CN1276723A (zh) 1997-09-05 1998-09-03 用作抗肿瘤剂的二硫杂环戊烯并吡咯酮及其相应的一氧化物和二氧化物
JP2000510440A JP2001515861A (ja) 1997-09-05 1998-09-03 抗腫瘍薬としてのジチオロピロロンおよびそれらの対応するモノオキサイドおよびジオキサイド
CN01131401A CN1360891A (zh) 1997-09-05 2001-09-06 用作抗肿瘤剂的二硫杂环戊烯并吡咯酮及其相应的一氧化物和二氧化物
HK02107990.3A HK1046373A1 (zh) 1997-09-05 2002-11-02 用作抗腫瘤劑的二硫雜環戊烯並吡咯酮及其相應的一氧化物和二氧化物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002212237A CA2212237A1 (en) 1997-09-05 1997-09-05 Novel antineoplastic agents

Publications (1)

Publication Number Publication Date
CA2212237A1 true CA2212237A1 (en) 1999-03-05

Family

ID=4161181

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002212237A Abandoned CA2212237A1 (en) 1997-09-05 1997-09-05 Novel antineoplastic agents

Country Status (7)

Country Link
EP (1) EP1009401A1 (zh)
JP (1) JP2001515861A (zh)
CN (2) CN1276723A (zh)
AU (1) AU759990B2 (zh)
CA (1) CA2212237A1 (zh)
HK (1) HK1046373A1 (zh)
WO (1) WO1999012543A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1238668A1 (en) * 2001-03-09 2002-09-11 Aventis Pharma Deutschland GmbH Use of thiolutin dioxide and its derivatives in the manufacture of a medicament for the treatment of CNS disorders and a process for the preparation thereof
JP4530667B2 (ja) * 2002-03-26 2010-08-25 ウェリケム バイオテック インコーポレーテッド 治療活性を有する新規ジチオロピロロン（ｄｉｔｈｉｏｌｏｐｙｒｒｏｌｏｎｅｓ）
KR101377358B1 (ko) * 2006-09-29 2014-03-27 웰리켐 바이오 테크 인크. 디티올로피롤론 화합물 및 그의 치료 적용
CN101381371B (zh) 2007-09-05 2011-05-18 上海医药工业研究院 二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1214130A (en) * 1982-10-26 1986-11-18 Stuart H. Rhodes Xenorhabdin antibiotics
DE19513040A1 (de) * 1995-03-29 1996-10-02 Schering Ag Neue Borneolester, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
WO1996032396A1 (en) * 1995-04-11 1996-10-17 John Malcolm Webster Xenorxides with antibacterial and antimycotic properties

Also Published As

Publication number Publication date
CN1276723A (zh) 2000-12-13
JP2001515861A (ja) 2001-09-25
AU759990B2 (en) 2003-05-01
WO1999012543A1 (en) 1999-03-18
AU9057098A (en) 1999-03-29
CN1360891A (zh) 2002-07-31
HK1046373A1 (zh) 2003-01-10
EP1009401A1 (en) 2000-06-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead