CA2206708A1 - Nouvelle proteine membranaire p76 d'helicobacter pylori - Google Patents
Nouvelle proteine membranaire p76 d'helicobacter pyloriInfo
- Publication number
- CA2206708A1 CA2206708A1 CA002206708A CA2206708A CA2206708A1 CA 2206708 A1 CA2206708 A1 CA 2206708A1 CA 002206708 A CA002206708 A CA 002206708A CA 2206708 A CA2206708 A CA 2206708A CA 2206708 A1 CA2206708 A1 CA 2206708A1
- Authority
- CA
- Canada
- Prior art keywords
- protein
- recovered
- nacl
- subjected
- centrifugation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000010749 gastric carcinoma Diseases 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960004198 guanidine Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000016379 mucosal immune response Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000011537 solubilization buffer Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention a pour objet une protéine d'H. pylori sous forme substantiellement purifiée, susceptible d'être obtenue à partir d'une fraction membranaire d'H. pylori et dont le poids moléculaire après électrophorèse sur gel de polyacrylamide 10 % en présence de SDS, apparaît de l'ordre de 76 kD.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR95/11891 | 1995-10-04 | ||
| FR9511891A FR2739623B1 (fr) | 1995-10-04 | 1995-10-04 | Nouvelle proteine membranaire p76 d'helicobacter pylori |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2206708A1 true CA2206708A1 (fr) | 1997-04-10 |
Family
ID=9483403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002206708A Abandoned CA2206708A1 (fr) | 1995-10-04 | 1996-10-04 | Nouvelle proteine membranaire p76 d'helicobacter pylori |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0797586A1 (fr) |
| JP (1) | JPH11505267A (fr) |
| CN (1) | CN1151172C (fr) |
| AU (1) | AU723885B2 (fr) |
| CA (1) | CA2206708A1 (fr) |
| FR (1) | FR2739623B1 (fr) |
| HU (1) | HUP9900427A3 (fr) |
| NO (1) | NO972531L (fr) |
| NZ (1) | NZ319639A (fr) |
| WO (1) | WO1997012908A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997047646A1 (fr) * | 1996-06-10 | 1997-12-18 | Boren Thomas | Adhesine d'helicobacter pylori se fixant a un antigene de groupe sanguin |
| DE19630390A1 (de) * | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
| WO1998043479A1 (fr) * | 1997-04-01 | 1998-10-08 | Merieux Oravax | POLYPEPTIDES D'HELICOBACTER DE 76 kDa, 32 kDa ET 50 kDa ET MOLECULES DE POLYNUCLEOTIDES CORRESPONDANTES |
| JP3869556B2 (ja) * | 1998-06-15 | 2007-01-17 | 勇 近藤 | ヘリコバクター・ピロリ由来抗原及びそれを用いたヘリコバクター・ピロリ感染の診断方法 |
| CA2329264A1 (fr) * | 1998-06-26 | 2000-01-06 | American Cyanamid Company | Nouveaux antigenes d'heliobacter pylori |
| JP5250812B2 (ja) * | 2006-04-27 | 2013-07-31 | 国立大学法人富山大学 | ヘリコバクター・ピロリ菌由来の新規抗原、抗原組成物およびピロリ菌抗体の検出方法。 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4139840B4 (de) * | 1990-12-04 | 2005-06-02 | Quidel Corp., San Diego | Antigen-Zubereitung zum Nachweis von H. pylori |
-
1995
- 1995-10-04 FR FR9511891A patent/FR2739623B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-04 CN CNB961917768A patent/CN1151172C/zh not_active Expired - Fee Related
- 1996-10-04 AU AU72202/96A patent/AU723885B2/en not_active Ceased
- 1996-10-04 HU HU9900427A patent/HUP9900427A3/hu unknown
- 1996-10-04 EP EP96933488A patent/EP0797586A1/fr not_active Withdrawn
- 1996-10-04 NZ NZ319639A patent/NZ319639A/xx unknown
- 1996-10-04 JP JP9514036A patent/JPH11505267A/ja not_active Withdrawn
- 1996-10-04 WO PCT/FR1996/001551 patent/WO1997012908A1/fr not_active Application Discontinuation
- 1996-10-04 CA CA002206708A patent/CA2206708A1/fr not_active Abandoned
-
1997
- 1997-06-03 NO NO972531A patent/NO972531L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1151172C (zh) | 2004-05-26 |
| CN1173876A (zh) | 1998-02-18 |
| MX9704110A (es) | 1998-07-31 |
| WO1997012908A1 (fr) | 1997-04-10 |
| AU7220296A (en) | 1997-04-28 |
| NZ319639A (en) | 1999-11-29 |
| FR2739623A1 (fr) | 1997-04-11 |
| JPH11505267A (ja) | 1999-05-18 |
| AU723885B2 (en) | 2000-09-07 |
| NO972531L (no) | 1997-07-30 |
| HUP9900427A2 (hu) | 1999-05-28 |
| NO972531D0 (no) | 1997-06-03 |
| HUP9900427A3 (en) | 2001-03-28 |
| FR2739623B1 (fr) | 1997-12-05 |
| EP0797586A1 (fr) | 1997-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |