CA2203236A1 - Fragments d'anticorps a specificite tumorale, proteines de fusion, et leurs utilisations - Google Patents
Fragments d'anticorps a specificite tumorale, proteines de fusion, et leurs utilisationsInfo
- Publication number
- CA2203236A1 CA2203236A1 CA 2203236 CA2203236A CA2203236A1 CA 2203236 A1 CA2203236 A1 CA 2203236A1 CA 2203236 CA2203236 CA 2203236 CA 2203236 A CA2203236 A CA 2203236A CA 2203236 A1 CA2203236 A1 CA 2203236A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- molecule
- region
- chain
- encodes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention porte sur des anticorps à chaîne unique recombinants capables de se lier spécifiquement à un antigène glucidique de type Lewis Y et sur des protéines de fusion comprenant ces anticorps. Plus particulièrement, l'invention a trait à des régions Fv (ScFv) à chaîne unique des anticorps monoclonaux B1, B3 et B5, à des régions Fv à chaîne unique humanisées de ces anticorps et à des protéines de fusion comprenant ces régions scFv. L'invention a trait également à un certain nombre de mutations stabilisatrices de l'anticorps B3 monoclonal liant un antigène Lewis B. En outre, l'invention a trait à des méthodes de détection des cellules renfermant un antigène de type Lewis Y chez un patient et à des méthodes permettant de tuer ces cellules ou d'inhiber leur croissance. L'invention porte également sur une méthode d'amélioration de l'affinité des anticorps dépourvus d'une sérine en position 95 de la région VH, qui consiste à placer une sérine en position 95 par mutation.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/331,396 US5889157A (en) | 1990-10-12 | 1994-10-28 | Humanized B3 antibody fragments, fusion proteins, and uses thereof |
US08/331,398 US5608039A (en) | 1990-10-12 | 1994-10-28 | Single chain B3 antibody fusion proteins and their uses |
US08/331,397 | 1994-10-28 | ||
US08/331,397 US5981726A (en) | 1990-10-12 | 1994-10-28 | Chimeric and mutationally stabilized tumor-specific B1, B3 and B5 antibody fragments; immunotoxic fusion proteins; and uses thereof |
US08/331,396 | 1994-10-28 | ||
US08/331,398 | 1994-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2203236A1 true CA2203236A1 (fr) | 1996-05-09 |
Family
ID=27406791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2203236 Abandoned CA2203236A1 (fr) | 1994-10-28 | 1995-10-26 | Fragments d'anticorps a specificite tumorale, proteines de fusion, et leurs utilisations |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0796334A1 (fr) |
AU (1) | AU717611B2 (fr) |
CA (1) | CA2203236A1 (fr) |
WO (1) | WO1996013594A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1127148B1 (fr) * | 1998-10-31 | 2012-08-08 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Variants de l'anticorps monoclonal anti-carcinome de type humain cc49 |
US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
WO2003025124A2 (fr) * | 2001-09-14 | 2003-03-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Immunoglobuline dotee d'un squelette particulier ; methodes de fabrication et d'utilisation |
CA2420494A1 (fr) * | 2003-02-28 | 2004-08-28 | Universite De Sherbrooke | Fonction de l'antigene tumoral ca 125 et utilisations therapeutiques de celui-ci |
US7569673B2 (en) | 2002-06-28 | 2009-08-04 | The United States Of America As Represented By The Department Of Health And Human Services | Humanized anti-tag 72 cc49 for diagnosis and therapy of human tumors |
CU23403A1 (es) | 2003-04-23 | 2009-08-04 | Centro Inmunologia Molecular | Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores |
US7589181B2 (en) | 2003-08-29 | 2009-09-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use |
MY146381A (en) * | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
GB201910899D0 (en) * | 2019-07-31 | 2019-09-11 | Scancell Ltd | Binding members |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993007286A1 (fr) * | 1991-09-30 | 1993-04-15 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Immunotoxines recombinees |
-
1995
- 1995-10-26 CA CA 2203236 patent/CA2203236A1/fr not_active Abandoned
- 1995-10-26 WO PCT/US1995/013811 patent/WO1996013594A1/fr not_active Application Discontinuation
- 1995-10-26 EP EP95939599A patent/EP0796334A1/fr not_active Withdrawn
- 1995-10-26 AU AU41355/96A patent/AU717611B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO1996013594A1 (fr) | 1996-05-09 |
WO1996013594A8 (fr) | 2000-04-06 |
EP0796334A1 (fr) | 1997-09-24 |
AU717611B2 (en) | 2000-03-30 |
AU4135596A (en) | 1996-05-23 |
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