CA2199502A1 - Analogues de nucleosides antiviraux contenant une base benzimidazole substituee fixee a une chaine carbocyclique - Google Patents
Analogues de nucleosides antiviraux contenant une base benzimidazole substituee fixee a une chaine carbocycliqueInfo
- Publication number
- CA2199502A1 CA2199502A1 CA002199502A CA2199502A CA2199502A1 CA 2199502 A1 CA2199502 A1 CA 2199502A1 CA 002199502 A CA002199502 A CA 002199502A CA 2199502 A CA2199502 A CA 2199502A CA 2199502 A1 CA2199502 A1 CA 2199502A1
- Authority
- CA
- Canada
- Prior art keywords
- dichloro
- benzimidazol
- hydroxymethyl
- cyclopentanediol
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Abstract
Cette invention se rapporte à des analogues de nucléosides antiviraux, qui contiennent une base benzimidazole substituée fixée à une chaîne carbocyclique à la place du résidu de sucre habituel. Ces composés sont représentés par les formules (I) et (I-1), où R?1¿ représente H, CH¿3? ou CH¿2?OH; R?2¿ représente H ou OH; R?3¿ représente H ou OH; ou R?2¿ et R?3¿ forment ensemble une liaison; R?4¿ représente amino, cyclopropylamino, cyclobutylamino, isopropylamino, tert-butylamino ou -NR?8¿R?9¿, où R?8¿ et R?9¿ forment, avec l'atome d'azote auquel ils sont liés, une chaîne hétérocyclique à 4, 5 ou 6 éléments; R?5¿ représente H; et R?6¿ et R?7¿ représentent Cl, à l'exclusion du composé (~)-(1R*, 2S*, 3S*, 5S*)-5-[5,6-Dichloro-2-(cyclopropylamino)-1<u>H</u>-benzimidazol-1-yl]-3-(hydroxyméthyl)-1,2-cyclopentanediol, et à condition qu'au moins l'un des éléments R?1¿, R?2¿ et R?3¿ représente ou contienne OH. Ces composés ont une action contre les infections par le virus de l'herpès, en particulier le cytomégalovirus, et également contre les infections par le virus de l'hépatite B.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US304,006 | 1994-09-09 | ||
US08/304,006 US5534535A (en) | 1992-03-09 | 1994-09-09 | Therapeutic nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2199502A1 true CA2199502A1 (fr) | 1996-03-14 |
Family
ID=23174626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002199502A Abandoned CA2199502A1 (fr) | 1994-09-09 | 1995-09-11 | Analogues de nucleosides antiviraux contenant une base benzimidazole substituee fixee a une chaine carbocyclique |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0779885A1 (fr) |
JP (1) | JPH10505092A (fr) |
CN (1) | CN1164855A (fr) |
AP (1) | AP741A (fr) |
AU (1) | AU3692895A (fr) |
BR (1) | BR9508826A (fr) |
CA (1) | CA2199502A1 (fr) |
CZ (1) | CZ71297A3 (fr) |
FI (1) | FI970959A (fr) |
HU (1) | HUT77440A (fr) |
IS (1) | IS4436A (fr) |
NO (1) | NO971070L (fr) |
NZ (1) | NZ294095A (fr) |
OA (1) | OA10601A (fr) |
PL (1) | PL319440A1 (fr) |
SK (1) | SK29197A3 (fr) |
WO (1) | WO1996007646A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912356A (en) * | 1995-09-11 | 1999-06-15 | Glaxo Wellcome Inc. | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
JP2001512453A (ja) | 1997-02-13 | 2001-08-21 | グラックス グループ リミテッド | ベンゾイミダゾール誘導体 |
EP1000080A1 (fr) | 1997-07-30 | 2000-05-17 | The Regents of The University of Michigan | Benzimidazoles de lyxofuranosyle en tant qu'agents antiviraux |
TR200103147T1 (tr) | 1999-12-27 | 2002-06-21 | Japan Tobacco Inc. | Kaynaşık halkalı bileşikler ve bunların ilaç olarak kullanımı. |
US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
AR035543A1 (es) * | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
CN1834090B (zh) * | 2005-03-18 | 2011-06-29 | 中国科学院上海药物研究所 | 苯并咪唑类化合物、其制备方法以及用途 |
ES2757928T3 (es) | 2007-08-02 | 2020-04-30 | Millennium Pharm Inc | Proceso para la síntesis de inhibidores de enzimas activadoras E1 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
-
1995
- 1995-09-11 CA CA002199502A patent/CA2199502A1/fr not_active Abandoned
- 1995-09-11 CN CN95196148A patent/CN1164855A/zh active Pending
- 1995-09-11 WO PCT/US1995/011366 patent/WO1996007646A1/fr not_active Application Discontinuation
- 1995-09-11 CZ CZ97712A patent/CZ71297A3/cs unknown
- 1995-09-11 AP APAP/P/1997/000940A patent/AP741A/en active
- 1995-09-11 EP EP95934402A patent/EP0779885A1/fr not_active Withdrawn
- 1995-09-11 BR BR9508826A patent/BR9508826A/pt not_active Application Discontinuation
- 1995-09-11 NZ NZ294095A patent/NZ294095A/en unknown
- 1995-09-11 HU HU9702310A patent/HUT77440A/hu unknown
- 1995-09-11 SK SK291-97A patent/SK29197A3/sk unknown
- 1995-09-11 PL PL95319440A patent/PL319440A1/xx unknown
- 1995-09-11 JP JP8509679A patent/JPH10505092A/ja not_active Ceased
- 1995-09-11 AU AU36928/95A patent/AU3692895A/en not_active Abandoned
-
1997
- 1997-03-06 FI FI970959A patent/FI970959A/fi unknown
- 1997-03-07 OA OA60973A patent/OA10601A/en unknown
- 1997-03-07 IS IS4436A patent/IS4436A/is unknown
- 1997-03-07 NO NO971070A patent/NO971070L/no unknown
Also Published As
Publication number | Publication date |
---|---|
AP9700940A0 (en) | 1997-04-30 |
NO971070L (no) | 1997-05-07 |
CZ71297A3 (en) | 1997-08-13 |
FI970959A0 (fi) | 1997-03-06 |
FI970959A (fi) | 1997-05-06 |
AU3692895A (en) | 1996-03-27 |
BR9508826A (pt) | 1997-09-30 |
IS4436A (is) | 1997-03-07 |
MX9701789A (es) | 1997-10-31 |
CN1164855A (zh) | 1997-11-12 |
NZ294095A (en) | 1998-08-26 |
WO1996007646A1 (fr) | 1996-03-14 |
PL319440A1 (en) | 1997-08-04 |
SK29197A3 (en) | 1997-10-08 |
OA10601A (en) | 2002-09-03 |
JPH10505092A (ja) | 1998-05-19 |
EP0779885A1 (fr) | 1997-06-25 |
AP741A (en) | 1999-04-26 |
NO971070D0 (no) | 1997-03-07 |
HUT77440A (hu) | 1998-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |