MX9701789A - Analogos de nucleosido antivirales que contienen una base de bencimidazol sustituida unida a un anillo carbociclico. - Google Patents

Analogos de nucleosido antivirales que contienen una base de bencimidazol sustituida unida a un anillo carbociclico.

Info

Publication number
MX9701789A
MX9701789A MX9701789A MX9701789A MX9701789A MX 9701789 A MX9701789 A MX 9701789A MX 9701789 A MX9701789 A MX 9701789A MX 9701789 A MX9701789 A MX 9701789A MX 9701789 A MX9701789 A MX 9701789A
Authority
MX
Mexico
Prior art keywords
carbocyclic ring
nucleoside analogues
substituted benzimidazole
base attached
antiviral nucleoside
Prior art date
Application number
MX9701789A
Other languages
English (en)
Other versions
MXPA97001789A (es
Inventor
Leroy B Townsend
Daluge Susan Mary
Original Assignee
Wellcome Found
Univ Mi
Chigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/304,006 external-priority patent/US5534535A/en
Application filed by Wellcome Found, Univ Mi, Chigan filed Critical Wellcome Found
Publication of MX9701789A publication Critical patent/MX9701789A/es
Publication of MXPA97001789A publication Critical patent/MXPA97001789A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

Los análogos de nucleosido antivirales contienen una base de bencimidazol sustituido unida a un anillo carbocíclico en lugar del residuo de azucar convencional. En las formulas (I) y (I-1), R1 es H, CH3, o CH2OH; R2 es H u OH; R3 es H u OH; o R2 y R3 forman juntos un enlace; R4 es amino, ciclopropilamino, ciclobutilamino, isopropilamino, terbutilamino, o -NR8R9, en donde R8R9, junto con el átomo de nitrogeno con el que están unidos, forman un anillo heterocíclico de 4, 5 ,o 6 miembros; R5 es H, y R6 y R7 son Cl, excluyendo al compuesto (+-)-(1R*, 2S*, 3S*, 5S*)-5-[5, 6-dicloro-2-(ciclopropilamino)-1H-bencimidazol-1-i l]-3-(hidroximetil)-1, 2-ciclopentanodiol, y en el entendido que cuando menos uno de R1, R2, y R3 sea o contenga OH. Los compuestos tienen actividad contra infecciones por virus de herpes, especialmente citomegalovirus, y también por virus de hepatitis B.
MXPA/A/1997/001789A 1994-09-09 1997-03-07 Analogos de nucleosido antivirales que contienen una base de bencimidazol sustituida unida a un anillo carbociclico MXPA97001789A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08304006 1994-09-09
US08/304,006 US5534535A (en) 1992-03-09 1994-09-09 Therapeutic nucleosides
PCT/US1995/011366 WO1996007646A1 (en) 1994-09-09 1995-09-11 Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring

Publications (2)

Publication Number Publication Date
MX9701789A true MX9701789A (es) 1997-10-31
MXPA97001789A MXPA97001789A (es) 1998-07-03

Family

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Also Published As

Publication number Publication date
AP9700940A0 (en) 1997-04-30
NO971070L (no) 1997-05-07
CZ71297A3 (en) 1997-08-13
FI970959A0 (fi) 1997-03-06
FI970959A (fi) 1997-05-06
AU3692895A (en) 1996-03-27
BR9508826A (pt) 1997-09-30
IS4436A (is) 1997-03-07
CN1164855A (zh) 1997-11-12
NZ294095A (en) 1998-08-26
WO1996007646A1 (en) 1996-03-14
PL319440A1 (en) 1997-08-04
SK29197A3 (en) 1997-10-08
OA10601A (en) 2002-09-03
JPH10505092A (ja) 1998-05-19
EP0779885A1 (en) 1997-06-25
AP741A (en) 1999-04-26
NO971070D0 (no) 1997-03-07
CA2199502A1 (en) 1996-03-14
HUT77440A (hu) 1998-04-28

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