AP741A - Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring. - Google Patents

Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring. Download PDF

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Publication number
AP741A
AP741A APAP/P/1997/000940A AP9700940A AP741A AP 741 A AP741 A AP 741A AP 9700940 A AP9700940 A AP 9700940A AP 741 A AP741 A AP 741A
Authority
AP
ARIPO
Prior art keywords
dichloro
cyclopentanediol
hydroxymethyl
benzimidazol
compound
Prior art date
Application number
APAP/P/1997/000940A
Other languages
English (en)
Other versions
AP9700940A0 (en
Inventor
Leroy B Townsend
Susan Mary Daluge
Original Assignee
The Wellcome Foundation Ltd
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/304,006 external-priority patent/US5534535A/en
Application filed by The Wellcome Foundation Ltd, Univ Michigan Regents filed Critical The Wellcome Foundation Ltd
Publication of AP9700940A0 publication Critical patent/AP9700940A0/xx
Application granted granted Critical
Publication of AP741A publication Critical patent/AP741A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1997/000940A 1994-09-09 1995-09-11 Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring. AP741A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/304,006 US5534535A (en) 1992-03-09 1994-09-09 Therapeutic nucleosides
PCT/US1995/011366 WO1996007646A1 (fr) 1994-09-09 1995-09-11 Analogues de nucleosides antiviraux contenant une base benzimidazole substituee fixee a une chaine carbocyclique

Publications (2)

Publication Number Publication Date
AP9700940A0 AP9700940A0 (en) 1997-04-30
AP741A true AP741A (en) 1999-04-26

Family

ID=23174626

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/000940A AP741A (en) 1994-09-09 1995-09-11 Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring.

Country Status (17)

Country Link
EP (1) EP0779885A1 (fr)
JP (1) JPH10505092A (fr)
CN (1) CN1164855A (fr)
AP (1) AP741A (fr)
AU (1) AU3692895A (fr)
BR (1) BR9508826A (fr)
CA (1) CA2199502A1 (fr)
CZ (1) CZ71297A3 (fr)
FI (1) FI970959A (fr)
HU (1) HUT77440A (fr)
IS (1) IS4436A (fr)
NO (1) NO971070L (fr)
NZ (1) NZ294095A (fr)
OA (1) OA10601A (fr)
PL (1) PL319440A1 (fr)
SK (1) SK29197A3 (fr)
WO (1) WO1996007646A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912356A (en) * 1995-09-11 1999-06-15 Glaxo Wellcome Inc. Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
JP2001512453A (ja) 1997-02-13 2001-08-21 グラックス グループ リミテッド ベンゾイミダゾール誘導体
EP1000080A1 (fr) 1997-07-30 2000-05-17 The Regents of The University of Michigan Benzimidazoles de lyxofuranosyle en tant qu'agents antiviraux
TR200103147T1 (tr) 1999-12-27 2002-06-21 Japan Tobacco Inc. Kaynaşık halkalı bileşikler ve bunların ilaç olarak kullanımı.
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
ES2757928T3 (es) 2007-08-02 2020-04-30 Millennium Pharm Inc Proceso para la síntesis de inhibidores de enzimas activadoras E1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018009A1 (fr) * 1992-03-09 1993-09-16 The Wellcome Foundation Limited Analogues de nucleosides anti-viraux

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018009A1 (fr) * 1992-03-09 1993-09-16 The Wellcome Foundation Limited Analogues de nucleosides anti-viraux

Also Published As

Publication number Publication date
AP9700940A0 (en) 1997-04-30
NO971070L (no) 1997-05-07
CZ71297A3 (en) 1997-08-13
FI970959A0 (fi) 1997-03-06
FI970959A (fi) 1997-05-06
AU3692895A (en) 1996-03-27
BR9508826A (pt) 1997-09-30
IS4436A (is) 1997-03-07
MX9701789A (es) 1997-10-31
CN1164855A (zh) 1997-11-12
NZ294095A (en) 1998-08-26
WO1996007646A1 (fr) 1996-03-14
PL319440A1 (en) 1997-08-04
SK29197A3 (en) 1997-10-08
OA10601A (en) 2002-09-03
JPH10505092A (ja) 1998-05-19
EP0779885A1 (fr) 1997-06-25
NO971070D0 (no) 1997-03-07
CA2199502A1 (fr) 1996-03-14
HUT77440A (hu) 1998-04-28

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