CA2198980A1 - Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them - Google Patents

Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Info

Publication number
CA2198980A1
CA2198980A1 CA002198980A CA2198980A CA2198980A1 CA 2198980 A1 CA2198980 A1 CA 2198980A1 CA 002198980 A CA002198980 A CA 002198980A CA 2198980 A CA2198980 A CA 2198980A CA 2198980 A1 CA2198980 A1 CA 2198980A1
Authority
CA
Canada
Prior art keywords
carbon atoms
zero
phenyl
substituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002198980A
Other languages
English (en)
French (fr)
Inventor
Udo Albus
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Wolfgang Scholz
Jan-Robert Schwark
Andreas Weichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of CA2198980A1 publication Critical patent/CA2198980A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002198980A 1996-03-04 1997-03-03 Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Abandoned CA2198980A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608161A DE19608161A1 (de) 1996-03-04 1996-03-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608161.0 1996-03-04

Publications (1)

Publication Number Publication Date
CA2198980A1 true CA2198980A1 (en) 1997-09-04

Family

ID=7787087

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002198980A Abandoned CA2198980A1 (en) 1996-03-04 1997-03-03 Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Country Status (30)

Country Link
US (1) US6262123B1 (ja)
EP (1) EP0794172B1 (ja)
JP (1) JP4039586B2 (ja)
KR (1) KR970065511A (ja)
CN (1) CN1071318C (ja)
AR (1) AR006051A1 (ja)
AT (1) ATE207462T1 (ja)
AU (1) AU707619B2 (ja)
BR (1) BR9701159A (ja)
CA (1) CA2198980A1 (ja)
CZ (1) CZ293144B6 (ja)
DE (2) DE19608161A1 (ja)
DK (1) DK0794172T3 (ja)
ES (1) ES2166481T3 (ja)
HR (1) HRP970125B1 (ja)
HU (1) HUP9700542A3 (ja)
ID (1) ID16106A (ja)
IL (1) IL120358A (ja)
MX (1) MX9701619A (ja)
MY (1) MY116861A (ja)
NO (1) NO308793B1 (ja)
NZ (1) NZ314325A (ja)
PL (1) PL185751B1 (ja)
PT (1) PT794172E (ja)
RU (1) RU2212400C2 (ja)
SI (1) SI0794172T1 (ja)
SK (1) SK283934B6 (ja)
TR (1) TR199700131A2 (ja)
TW (1) TW440558B (ja)
ZA (1) ZA971815B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001879A1 (de) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN100371328C (zh) * 2006-01-19 2008-02-27 中国药科大学 取代苯甲酰基胍衍生物、其制备方法及其医药用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW250477B (ja) 1992-12-15 1995-07-01 Hoechst Ag
ATE157351T1 (de) 1993-02-20 1997-09-15 Hoechst Ag Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament
DE4318756A1 (de) 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4404183A1 (de) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-Amino-1-piperidylbenzoylguanidine
DE4417004A1 (de) 1994-05-13 1995-11-16 Hoechst Ag Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421495A1 (de) * 1994-06-20 1995-12-21 Merck Patent Gmbh Heterocyclyloxy-benzoylguanidine
DE4430213A1 (de) * 1994-08-28 1996-02-29 Merck Patent Gmbh Arylbenzoylguanidine
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate
DE19624178A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
HRP970125A2 (en) 1998-04-30
HUP9700542A3 (en) 1998-01-28
AR006051A1 (es) 1999-07-21
ES2166481T3 (es) 2002-04-16
HUP9700542A1 (en) 1997-12-29
SK27697A3 (en) 1997-11-05
CZ293144B6 (cs) 2004-02-18
US6262123B1 (en) 2001-07-17
EP0794172B1 (de) 2001-10-24
TR199700131A2 (tr) 1997-09-21
ID16106A (id) 1997-09-04
NZ314325A (en) 1998-02-26
PL318415A1 (en) 1997-09-15
TW440558B (en) 2001-06-16
IL120358A (en) 2002-04-21
RU2212400C2 (ru) 2003-09-20
ATE207462T1 (de) 2001-11-15
SI0794172T1 (en) 2002-10-31
CN1071318C (zh) 2001-09-19
NO970963D0 (no) 1997-03-03
CZ65497A3 (cs) 1998-05-13
ZA971815B (en) 1997-09-04
HRP970125B1 (en) 2002-06-30
MX9701619A (es) 1998-04-30
BR9701159A (pt) 1998-12-15
CN1160042A (zh) 1997-09-24
JP4039586B2 (ja) 2008-01-30
PT794172E (pt) 2002-02-28
HU9700542D0 (en) 1997-04-28
JPH107644A (ja) 1998-01-13
PL185751B1 (pl) 2003-07-31
MY116861A (en) 2004-04-30
DK0794172T3 (da) 2002-02-11
SK283934B6 (sk) 2004-05-04
EP0794172A1 (de) 1997-09-10
AU707619B2 (en) 1999-07-15
IL120358A0 (en) 1997-07-13
AU1499797A (en) 1997-09-11
DE19608161A1 (de) 1997-09-11
DE59705019D1 (de) 2001-11-29
NO970963L (no) 1997-09-05
NO308793B1 (no) 2000-10-30
KR970065511A (ko) 1997-10-13

Similar Documents

Publication Publication Date Title
CA2130944C (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
US5679712A (en) Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them
US6025349A (en) Phenyl.-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
US5883133A (en) Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them
US6632840B1 (en) Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them
US5747541A (en) Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them
US5567734A (en) Phenyl-substituted alkylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them
US5559153A (en) Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
CA2206758C (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US5869531A (en) Fluoroalkyl substituted benzoylguanidines
AU707619B2 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
US6617344B2 (en) Heterocyclically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them
CA2163598A1 (en) Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US5856574A (en) Ortho-subsituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
US6153651A (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
MXPA97001619A (es) Benzoilguanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued