CA2196064A1 - Derives 4-(4-methanesulfonamidophenyl)butylamine exercant une activite antiarhythmique - Google Patents

Derives 4-(4-methanesulfonamidophenyl)butylamine exercant une activite antiarhythmique

Info

Publication number
CA2196064A1
CA2196064A1 CA002196064A CA2196064A CA2196064A1 CA 2196064 A1 CA2196064 A1 CA 2196064A1 CA 002196064 A CA002196064 A CA 002196064A CA 2196064 A CA2196064 A CA 2196064A CA 2196064 A1 CA2196064 A1 CA 2196064A1
Authority
CA
Canada
Prior art keywords
formula
compound
mixture
phenyl
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002196064A
Other languages
English (en)
Inventor
Jackson B. Hester, Jr.
J. Kenneth Gibson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2196064A1 publication Critical patent/CA2196064A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Méthanesulfonamides de la formule (I), ou leurs sels pharmaceutiquement acceptables. Dans cette formule, R¿3? et un C¿1-7? alkyle substitué par un C¿3-7? cycloalkyle, ou un C¿1-10? alkyle substitué par 1 à 8 atomes de fluore, 1 à 3 substituants hydroxy, 1 à 3 substituants C¿1-5? acyloxy ou 1 à 3 substituants de C¿1-4? alcoxy. Ces composés se révèlent utiles comme agents antiarhythmiques de la classe III et se révèlent stables par rapport à un métabolisme rapide. L'invention porte également sur des méthodes de traitement des arhythmies cardiaques à l'aide de composés de la formule (I) ainsi que de compositions issues de ces composés.
CA002196064A 1994-09-12 1995-08-23 Derives 4-(4-methanesulfonamidophenyl)butylamine exercant une activite antiarhythmique Abandoned CA2196064A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30467394A 1994-09-12 1994-09-12
US304,673 1994-09-12

Publications (1)

Publication Number Publication Date
CA2196064A1 true CA2196064A1 (fr) 1996-03-21

Family

ID=23177488

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002196064A Abandoned CA2196064A1 (fr) 1994-09-12 1995-08-23 Derives 4-(4-methanesulfonamidophenyl)butylamine exercant une activite antiarhythmique

Country Status (5)

Country Link
EP (1) EP0781273A1 (fr)
JP (1) JPH10505829A (fr)
AU (1) AU688117B2 (fr)
CA (1) CA2196064A1 (fr)
WO (1) WO1996008471A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3566886D1 (en) * 1984-05-04 1989-01-26 Upjohn Co N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
US4569801A (en) * 1984-10-15 1986-02-11 Eli Lilly And Company Alkylsulfonamidophenylalkylamines
AU641676B2 (en) * 1989-07-25 1993-09-30 Pharmacia & Upjohn Company Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides
US5208252A (en) * 1992-07-24 1993-05-04 Ortho Pharmaceutical Corporation Aminoethylthiophene derivatives

Also Published As

Publication number Publication date
AU688117B2 (en) 1998-03-05
EP0781273A1 (fr) 1997-07-02
JPH10505829A (ja) 1998-06-09
AU3407095A (en) 1996-03-29
WO1996008471A1 (fr) 1996-03-21

Similar Documents

Publication Publication Date Title
CN105130855B (zh) 二酰基化的羟基胺衍生物及其用途
CN102753520A (zh) N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物
EA023104B1 (ru) Аналоги эпоксиэйкозатриеновой кислоты и способы их получения и использования
RO109645B1 (ro) Derivati de fenilacetamida si procedee pentru prepararea acestora
EP4410786A1 (fr) Composé de sulfonamide, son procédé de préparation et son utilisation
KR19980071076A (ko) 3-아미노-1,2-벤조이소옥사졸 유도체, 이의 제조방법 및 용도
DE69102503T2 (de) N-Phenyl-N'-alkylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende Antitumorzusammensetzungen.
EP0484378B1 (fr) Amine-alcenyle-phenyle-alcanesulfonamides tertiaires antiarythmiques
US20030109570A1 (en) Benzothiophene derivatives and medicinal use thereof
EP0819118B1 (fr) Inhibiteurs de canaux a ions potassium
USRE38102E1 (en) Use of a pyridazinone derivative
CA2196064A1 (fr) Derives 4-(4-methanesulfonamidophenyl)butylamine exercant une activite antiarhythmique
CA2285556A1 (fr) Composes calcilytiques
PT87005B (pt) Processo para a preparacao de agentes anti-arritmicos de n-fenetilaminoalquil-benzamidas
CA2207545C (fr) Enantiomeres (s) de methane-sulfonamides antiarythmiques
US5874475A (en) Antiarrhythmic (S)-enantiomers of methanesulfonamides
KR20010031439A (ko) 도페틸리드 다형태
NO173822B (no) Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse (4-amino-2,6-dimetylfenylsulfonyl)nitrometan og farmasoeytisk akseptable salter derav
KR19980701303A (ko) 메탄설폰아미드의 항부정맥성 (s)-에난티오머
MXPA97005192A (en) (s) - antiarrhythmic banants of metansulfonami
JPS60246315A (ja) 選択的ｄ−２ドパミン受容体作用薬
JPH07103026B2 (ja) カルシウム拮抗剤
JP2000053619A (ja) 芳香族抗真菌剤

Legal Events

Date Code Title Description
FZDE Dead