CA2194563A1 - Derives heterocycliques anti-helicobacter d'azolones - Google Patents
Derives heterocycliques anti-helicobacter d'azolonesInfo
- Publication number
- CA2194563A1 CA2194563A1 CA002194563A CA2194563A CA2194563A1 CA 2194563 A1 CA2194563 A1 CA 2194563A1 CA 002194563 A CA002194563 A CA 002194563A CA 2194563 A CA2194563 A CA 2194563A CA 2194563 A1 CA2194563 A1 CA 2194563A1
- Authority
- CA
- Canada
- Prior art keywords
- 4alkyl
- pyridinyl
- formula
- optionally substituted
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymerization Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
L'invention concerne des composés de formule (I), leurs sels d'addition pharmaceutiquement acceptables et leurs formes stéréochimiquement isomériques. Dans cette formule, Y est CH ou bien N; R?1¿, R?2¿ et R?3¿ sont chacun indépendamment hydrogène ou alkyle C¿1-4?; R?4¿ et R?5¿ sont chacun indépendamment hydrogène, halo, alkyle C¿1-4?, alkyloxy C¿1-4?, hydroxy, trifluorométhyle, trifluorométhyloxy ou difluorométhyloxy; R?6¿ est pyridinyle éventuellement substitué avec jusqu'à deux groupes alkyle C¿1-4?; di(alkyle C¿1-4?)hydroxypyridinyle; di(alkyle C¿1-4?)alkyloxypyridinyle C¿1-4?; pyridazinyle éventuellement substitué avec alkyloxy C¿1-4?; pyrimidinyle éventuellement substitué avec hydroxy ou alkyloxy C¿1-4?; thiazolyle éventuellement substitué avec alkyle C¿1-4?; thiadiazolyle éventuellement substitué avec alkyle C¿1-4?; benzoxazolyle ou benzothiazolyle; ou bien R?6¿ est pyrazinyle ou pyridazinyle substitué avec alkyle C¿1-4?; Z est C=O ou CHOH; et (a) est un radical de formule (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), ou bien (a-7). L'invention concerne également des compositions comprenant lesdits composés, des procédés pour les préparer et l'utilisation de ces composés comme médicament.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94202018.1 | 1994-07-12 | ||
| EP94202018 | 1994-07-12 | ||
| PCT/EP1995/002616 WO1996001821A1 (fr) | 1994-07-12 | 1995-07-05 | Derives heterocycliques anti-helicobacter d'azolones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2194563A1 true CA2194563A1 (fr) | 1996-01-25 |
Family
ID=8217031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002194563A Abandoned CA2194563A1 (fr) | 1994-07-12 | 1995-07-05 | Derives heterocycliques anti-helicobacter d'azolones |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5607932A (fr) |
| EP (1) | EP0770073A1 (fr) |
| JP (1) | JPH10502383A (fr) |
| CN (1) | CN1067999C (fr) |
| AU (1) | AU684986B2 (fr) |
| BR (1) | BR9508380A (fr) |
| CA (1) | CA2194563A1 (fr) |
| CZ (1) | CZ2697A3 (fr) |
| FI (1) | FI970110A (fr) |
| HU (1) | HUT76641A (fr) |
| IL (1) | IL114534A (fr) |
| MX (1) | MX9700338A (fr) |
| MY (1) | MY131785A (fr) |
| NO (1) | NO310289B1 (fr) |
| NZ (1) | NZ290116A (fr) |
| PL (1) | PL318142A1 (fr) |
| RU (1) | RU2152940C1 (fr) |
| SK (1) | SK2197A3 (fr) |
| WO (1) | WO1996001821A1 (fr) |
| ZA (1) | ZA955753B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100411190B1 (ko) * | 1995-12-26 | 2004-03-26 | 에스케이케미칼주식회사 | 에틸렌글리콜의회수방법 |
| KR20000005291A (ko) | 1996-06-25 | 2000-01-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 옥사졸론 유도체 및 항-헬리코박터 파일로리 제제로서의 이의용도 |
| WO1997049703A2 (fr) * | 1996-06-25 | 1997-12-31 | Takeda Chemical Industries, Ltd. | DERIVES DE L'OXAZOLONE ET LEUR UTILISATION EN TANT QU'AGENT ANTI-$i(HELICOBACTER PYLORI) |
| CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| CA2580787A1 (fr) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et utilisation de ceux-ci comme agents therapeutiques |
| AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP2269610A3 (fr) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Dérivés hétérocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase |
| CA2618646A1 (fr) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Derives aminothiazole utilises en tant qu'inhibiteurs de la stearoyle-coa desaturase humaine |
| MX2010014572A (es) | 2008-06-27 | 2011-03-24 | Novartis Ag | Compuestos organicos. |
| EP2852589B1 (fr) * | 2012-05-22 | 2021-04-28 | Autifony Therapeutics Limited | Triazoles en tant qu'inhibiteurs de kv3 |
| EP3464262B1 (fr) * | 2016-05-27 | 2020-02-26 | Bristol-Myers Squibb Company | Utilisation de triazolones et de tétrazolones comme inhibiteurs de la voie de signalisation rho/rock |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| CA1331757C (fr) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibant les 4-(4-phenyl-1-piperazinyl)phenols |
| CA2076257A1 (fr) * | 1991-09-13 | 1993-03-14 | Jan Heeres | Derives de 4-{4-¬4-(4-hydroxyphenyl)-1-piperazinyl|phenyl}-5-methyl-3h-1,2,4-triazol-3-one |
| TW279864B (fr) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv |
-
1995
- 1995-05-23 US US08/447,503 patent/US5607932A/en not_active Expired - Fee Related
- 1995-07-05 CN CN95194021A patent/CN1067999C/zh not_active Expired - Fee Related
- 1995-07-05 BR BR9508380A patent/BR9508380A/pt unknown
- 1995-07-05 CZ CZ9726A patent/CZ2697A3/cs unknown
- 1995-07-05 AU AU30755/95A patent/AU684986B2/en not_active Ceased
- 1995-07-05 RU RU97102151/04A patent/RU2152940C1/ru active
- 1995-07-05 WO PCT/EP1995/002616 patent/WO1996001821A1/fr not_active Application Discontinuation
- 1995-07-05 CA CA002194563A patent/CA2194563A1/fr not_active Abandoned
- 1995-07-05 PL PL95318142A patent/PL318142A1/xx unknown
- 1995-07-05 JP JP8504109A patent/JPH10502383A/ja active Pending
- 1995-07-05 EP EP95926390A patent/EP0770073A1/fr not_active Withdrawn
- 1995-07-05 MX MX9700338A patent/MX9700338A/es unknown
- 1995-07-05 HU HU9700077A patent/HUT76641A/hu unknown
- 1995-07-05 NZ NZ290116A patent/NZ290116A/en unknown
- 1995-07-05 SK SK21-97A patent/SK2197A3/sk unknown
- 1995-07-11 IL IL11453495A patent/IL114534A/xx active IP Right Grant
- 1995-07-11 ZA ZA955753A patent/ZA955753B/xx unknown
- 1995-07-12 MY MYPI95001962A patent/MY131785A/en unknown
-
1997
- 1997-01-09 NO NO19970086A patent/NO310289B1/no unknown
- 1997-01-10 FI FI970110A patent/FI970110A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL114534A (en) | 1999-08-17 |
| RU2152940C1 (ru) | 2000-07-20 |
| SK2197A3 (en) | 1997-11-05 |
| EP0770073A1 (fr) | 1997-05-02 |
| HUT76641A (en) | 1997-10-28 |
| AU3075595A (en) | 1996-02-09 |
| NO970086D0 (no) | 1997-01-09 |
| FI970110A0 (fi) | 1997-01-10 |
| JPH10502383A (ja) | 1998-03-03 |
| MY131785A (en) | 2007-08-30 |
| NZ290116A (en) | 1997-11-24 |
| CN1152310A (zh) | 1997-06-18 |
| IL114534A0 (en) | 1995-11-27 |
| NO970086L (no) | 1997-03-10 |
| CZ2697A3 (en) | 1997-09-17 |
| ZA955753B (en) | 1997-01-11 |
| PL318142A1 (en) | 1997-05-12 |
| BR9508380A (pt) | 1997-12-23 |
| HU9700077D0 (en) | 1997-02-28 |
| FI970110A (fi) | 1997-01-10 |
| CN1067999C (zh) | 2001-07-04 |
| MX9700338A (es) | 1997-05-31 |
| AU684986B2 (en) | 1998-01-08 |
| US5607932A (en) | 1997-03-04 |
| NO310289B1 (no) | 2001-06-18 |
| WO1996001821A1 (fr) | 1996-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |