CA2192708A1 - Vecteur d'apport de substances bio-efficaces a gelification in situ et methode d'utilisation - Google Patents

Vecteur d'apport de substances bio-efficaces a gelification in situ et methode d'utilisation

Info

Publication number
CA2192708A1
CA2192708A1 CA 2192708 CA2192708A CA2192708A1 CA 2192708 A1 CA2192708 A1 CA 2192708A1 CA 2192708 CA2192708 CA 2192708 CA 2192708 A CA2192708 A CA 2192708A CA 2192708 A1 CA2192708 A1 CA 2192708A1
Authority
CA
Canada
Prior art keywords
composition
delivery vehicle
polyacid
pharmaceutically acceptable
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2192708
Other languages
English (en)
Inventor
Kenneth J. Himmelstein
Bert O. Haglund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Nebraska
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2192708A1 publication Critical patent/CA2192708A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un complexe interpolymère d'un polyacide et d'un polymère soluble dans l'eau et non-ionique, de préférence l'acide polyméthacrylique et le polyéthylénéglycol forme un complexe stable non-soluble dans l'eau à un pH acide, et est transformé en liquide extrudable par adjonction d'une quantité appropriée d'agent de solubilisation, de préférence de l'éthanol. Le complexe ainsi obtenu est particulièrement utile comme vecteur injectable et à libération prolongée de substances bio-efficaces, et notamment d'agents thérapeutiques.
CA 2192708 1994-06-17 1995-06-09 Vecteur d'apport de substances bio-efficaces a gelification in situ et methode d'utilisation Abandoned CA2192708A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26173194A 1994-06-17 1994-06-17
US08/261,731 1994-06-17

Publications (1)

Publication Number Publication Date
CA2192708A1 true CA2192708A1 (fr) 1995-12-28

Family

ID=22994617

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2192708 Abandoned CA2192708A1 (fr) 1994-06-17 1995-06-09 Vecteur d'apport de substances bio-efficaces a gelification in situ et methode d'utilisation

Country Status (5)

Country Link
EP (1) EP0802787A4 (fr)
JP (1) JPH10501814A (fr)
AU (1) AU2638795A (fr)
CA (1) CA2192708A1 (fr)
WO (1) WO1995035093A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737406B1 (fr) † 1995-08-04 1997-10-24 Sederma Sa Gel a activite physique pour produits cosmetiques
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19701912C1 (de) * 1997-01-10 1998-05-14 Jenapharm Gmbh Injizierbares Implantat
US6596291B2 (en) 1997-12-05 2003-07-22 Thomas A. Bell Compositions and methods for treating surfaces infected with ectoparasitic insects
AU769224B2 (en) * 1998-12-28 2004-01-22 Taisho Pharmaceutical Co., Ltd. External preparation
AU4977800A (en) * 1999-04-26 2000-11-10 California Institute Of Technology (in situ) forming hydrogels
US7737185B2 (en) 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
US7173064B2 (en) 2001-07-09 2007-02-06 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
MXPA04000097A (es) 2001-07-09 2004-05-21 Zonagen Inc Metodo y materiales para el tratamiento de deficiencias de testosterona en varones.
SE0302509D0 (sv) 2003-09-19 2003-09-19 Amersham Biosciences Ab Matrix for separation of polyethers and method of separation
MX2007009077A (es) 2005-02-04 2007-09-13 Repros Therapeutics Inc Metodos y materiales con trans-clomifeno para el tratamiento de la infertilidad masculina.
CN101163467B (zh) 2005-03-22 2012-07-18 雷普罗斯治疗公司 反式氯米芬的制药用途
CN101896174B (zh) 2007-10-16 2012-10-31 利普生物药剂公司 用于治疗代谢综合征的珠氯米芬
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
AU2013338311A1 (en) 2012-11-02 2015-05-14 Repros Therapeutics Inc. Trans-clomiphene for use in cancer therapy
WO2016170531A1 (fr) * 2015-04-20 2016-10-27 Botanocap Ltd. Microcapsules à noyau liquide et solide formées par complexation interpolymérique
WO2020033677A1 (fr) 2018-08-08 2020-02-13 Johnson Lanny Leo Méthodes de diagnostic et de traitement d'implants infectés

Also Published As

Publication number Publication date
WO1995035093A1 (fr) 1995-12-28
EP0802787A1 (fr) 1997-10-29
JPH10501814A (ja) 1998-02-17
EP0802787A4 (fr) 1998-09-02
AU2638795A (en) 1996-01-15

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Legal Events

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