CA2191776A1 - Automated tissue assay using standardized chemicals and packages - Google Patents
Automated tissue assay using standardized chemicals and packagesInfo
- Publication number
- CA2191776A1 CA2191776A1 CA002191776A CA2191776A CA2191776A1 CA 2191776 A1 CA2191776 A1 CA 2191776A1 CA 002191776 A CA002191776 A CA 002191776A CA 2191776 A CA2191776 A CA 2191776A CA 2191776 A1 CA2191776 A1 CA 2191776A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- receptacle
- workstation
- disposed
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 title claims description 105
- 238000003556 assay Methods 0.000 title abstract description 38
- 238000000034 method Methods 0.000 claims abstract description 416
- 230000008569 process Effects 0.000 claims abstract description 135
- 238000004458 analytical method Methods 0.000 claims abstract description 54
- 238000012545 processing Methods 0.000 claims abstract description 19
- 239000000523 sample Substances 0.000 claims description 232
- 239000003153 chemical reaction reagent Substances 0.000 claims description 140
- 239000012530 fluid Substances 0.000 claims description 64
- 238000011534 incubation Methods 0.000 claims description 56
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
- 230000008878 coupling Effects 0.000 claims description 39
- 238000010168 coupling process Methods 0.000 claims description 39
- 238000005859 coupling reaction Methods 0.000 claims description 39
- 239000001993 wax Substances 0.000 claims description 39
- 102000004190 Enzymes Human genes 0.000 claims description 38
- 108090000790 Enzymes Proteins 0.000 claims description 38
- 238000012360 testing method Methods 0.000 claims description 37
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 36
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 33
- 230000004044 response Effects 0.000 claims description 33
- 239000000834 fixative Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 claims description 28
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 27
- 230000036571 hydration Effects 0.000 claims description 25
- 238000006703 hydration reaction Methods 0.000 claims description 25
- 238000001816 cooling Methods 0.000 claims description 23
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 20
- 239000004033 plastic Substances 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 16
- 238000012544 monitoring process Methods 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 239000000975 dye Substances 0.000 claims description 15
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 claims description 15
- 238000000926 separation method Methods 0.000 claims description 15
- 239000003298 DNA probe Substances 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 14
- 230000003287 optical effect Effects 0.000 claims description 13
- 239000012188 paraffin wax Substances 0.000 claims description 13
- 230000005855 radiation Effects 0.000 claims description 13
- 238000004821 distillation Methods 0.000 claims description 12
- 229960002523 mercuric chloride Drugs 0.000 claims description 12
- LWJROJCJINYWOX-UHFFFAOYSA-L mercury dichloride Chemical compound Cl[Hg]Cl LWJROJCJINYWOX-UHFFFAOYSA-L 0.000 claims description 12
- 238000005057 refrigeration Methods 0.000 claims description 12
- 230000001105 regulatory effect Effects 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 11
- 108020003215 DNA Probes Proteins 0.000 claims description 11
- 230000000970 DNA cross-linking effect Effects 0.000 claims description 11
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 11
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 11
- 239000000020 Nitrocellulose Substances 0.000 claims description 11
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims description 11
- 238000004166 bioassay Methods 0.000 claims description 11
- 238000009792 diffusion process Methods 0.000 claims description 11
- 239000003822 epoxy resin Substances 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 229910001385 heavy metal Inorganic materials 0.000 claims description 11
- 229920001220 nitrocellulos Polymers 0.000 claims description 11
- 238000000399 optical microscopy Methods 0.000 claims description 11
- 239000012285 osmium tetroxide Substances 0.000 claims description 11
- 229910000489 osmium tetroxide Inorganic materials 0.000 claims description 11
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 claims description 11
- 229920000647 polyepoxide Polymers 0.000 claims description 11
- 230000002285 radioactive effect Effects 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000012192 staining solution Substances 0.000 claims description 11
- 239000000979 synthetic dye Substances 0.000 claims description 11
- 238000009423 ventilation Methods 0.000 claims description 11
- 239000011534 wash buffer Substances 0.000 claims description 11
- 230000009471 action Effects 0.000 claims description 10
- 230000033001 locomotion Effects 0.000 claims description 10
- 230000004888 barrier function Effects 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 6
- 238000009826 distribution Methods 0.000 claims description 4
- 229920000136 polysorbate Polymers 0.000 claims description 4
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000011800 void material Substances 0.000 claims 15
- 238000001311 chemical methods and process Methods 0.000 claims 10
- 238000001493 electron microscopy Methods 0.000 claims 10
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 10
- 238000010998 test method Methods 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 description 55
- 239000000872 buffer Substances 0.000 description 16
- 239000007788 liquid Substances 0.000 description 15
- 230000000887 hydrating effect Effects 0.000 description 13
- 238000007373 indentation Methods 0.000 description 13
- 102100035701 Serine/arginine-rich splicing factor 10 Human genes 0.000 description 11
- 101710117510 Serine/arginine-rich splicing factor 10 Proteins 0.000 description 11
- 238000013461 design Methods 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 238000010186 staining Methods 0.000 description 9
- 230000002093 peripheral effect Effects 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 230000032258 transport Effects 0.000 description 6
- 230000001960 triggered effect Effects 0.000 description 6
- 240000001327 Echinochloa stagnina Species 0.000 description 5
- 235000001418 Echinochloa stagnina Nutrition 0.000 description 5
- 235000001797 Lavandula macra Nutrition 0.000 description 5
- 235000001803 Lavandula setifera Nutrition 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 5
- 230000008595 infiltration Effects 0.000 description 5
- 238000001764 infiltration Methods 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000013256 coordination polymer Substances 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 235000012431 wafers Nutrition 0.000 description 3
- 108090001008 Avidin Proteins 0.000 description 2
- JUQPZRLQQYSMEQ-UHFFFAOYSA-N CI Basic red 9 Chemical compound [Cl-].C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[NH2+])C=C1 JUQPZRLQQYSMEQ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 229940052223 basic fuchsin Drugs 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 239000002991 molded plastic Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 description 1
- -1 21 counterstains Substances 0.000 description 1
- IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 101100004280 Caenorhabditis elegans best-2 gene Proteins 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 101100130497 Drosophila melanogaster Mical gene Proteins 0.000 description 1
- 241000490229 Eucephalus Species 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 241001490312 Lithops pseudotruncatella Species 0.000 description 1
- 101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 241000042032 Petrocephalus catostoma Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 235000014328 Schoenoplectus acutus var occidentalis Nutrition 0.000 description 1
- 244000136421 Scirpus acutus Species 0.000 description 1
- 235000014326 Scirpus californicus Nutrition 0.000 description 1
- 235000017913 Scirpus lacustris Nutrition 0.000 description 1
- 101100537665 Trypanosoma cruzi TOR gene Proteins 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 230000005574 cross-species transmission Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000012804 iterative process Methods 0.000 description 1
- 230000007775 late Effects 0.000 description 1
- 239000003562 lightweight material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- HKSZLNNOFSGOKW-HMWZOHBLSA-N staurosporine Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@@H]1C[C@H](NC)[C@H](OC)[C@@]4(C)O1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 101150093706 tor gene Proteins 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
- B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
- B25J9/00—Programme-controlled manipulators
- B25J9/16—Programme controls
- B25J9/1679—Programme controls characterised by the tasks executed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
- B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
- B25J9/00—Programme-controlled manipulators
- B25J9/16—Programme controls
- B25J9/1656—Programme controls characterised by programming, planning systems for manipulators
- B25J9/1671—Programme controls characterised by programming, planning systems for manipulators characterised by simulation, either to verify existing program or to create and verify new program, CAD/CAM oriented, graphic oriented programming systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N2035/0093—Scheduling random access not determined by physical position
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
- G01N2035/1093—Cylindrical, e.g. variable radius and angle
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/40—Robotics, robotics mapping to robotics vision
- G05B2219/40097—Select stations with mouse to create process steps
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/40—Robotics, robotics mapping to robotics vision
- G05B2219/40098—Show grid locations with symbols of workstations
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/40—Robotics, robotics mapping to robotics vision
- G05B2219/40099—Graphical user interface for robotics, visual robot user interface
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/40—Robotics, robotics mapping to robotics vision
- G05B2219/40108—Generating possible sequence of steps as function of timing and conflicts
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/40—Robotics, robotics mapping to robotics vision
- G05B2219/40113—Task planning
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/40—Robotics, robotics mapping to robotics vision
- G05B2219/40463—Shortest distance in time, or metric, time optimal
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/45—Nc applications
- G05B2219/45092—Analysing or chemical synthesis robot, moving samples from station to station
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/45—Nc applications
- G05B2219/45118—Endoscopic, laparoscopic manipulator
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/115831—Condition or time responsive
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Robotics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/252,282 US5696887A (en) | 1991-08-05 | 1994-05-31 | Automated tissue assay using standardized chemicals and packages |
US08/252,282 | 1994-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2191776A1 true CA2191776A1 (en) | 1995-12-07 |
Family
ID=22955357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002191776A Abandoned CA2191776A1 (en) | 1994-05-31 | 1995-05-17 | Automated tissue assay using standardized chemicals and packages |
Country Status (6)
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5696887A (en) * | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
DE69735211T2 (de) * | 1996-09-18 | 2006-08-17 | Kabushiki Kaisha Tiyoda Seisakusho, Koushoku | Flüssigkeitsbehandlungsvorrichtung fur biologische proben |
US5839091A (en) * | 1996-10-07 | 1998-11-17 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US6735531B2 (en) | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
DE19652339A1 (de) * | 1996-12-17 | 1998-06-18 | Microm Laborgeraete Gmbh | Vorrichtung zur Behandlung von Objekten |
US5985214A (en) | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
ATE407353T1 (de) * | 1997-08-20 | 2008-09-15 | Univ Miami | Hochqualitatives durchlaufendes verfahren zur fixierung, dehydratisierung, entfettung und imprägnation von geweben |
US6793890B2 (en) * | 1997-08-20 | 2004-09-21 | The University Of Miami | Rapid tissue processor |
EP0962775A1 (en) * | 1998-04-28 | 1999-12-08 | Nevio Recinelli | Automatic analyzer with single robot arm and U-shaped reaction capillary vessels |
CA2273729A1 (en) | 1998-07-14 | 2000-01-14 | Bayer Corporation | Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics |
US8298485B2 (en) * | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US7897106B2 (en) * | 1999-07-08 | 2011-03-01 | Lee Angros | Situ heat induced antigen recovery and staining apparatus and method |
AU6079500A (en) * | 1999-07-08 | 2001-01-30 | Lee Angros | Antigen recovery and/or staining apparatus and method |
KR100675698B1 (ko) | 1999-08-06 | 2007-02-01 | 써모 바이오스타, 인크. | 완전한 샘플 처리 능력을 포함하는 자동화된 진료 검출 시스템 |
US20010043884A1 (en) * | 1999-12-14 | 2001-11-22 | Ervin Essenfeld | Microwave unit and system for tissue processing |
DE10041226A1 (de) * | 2000-08-22 | 2002-03-07 | Leica Microsystems | Verfahren zur Behandlung von Objekten |
DE10052833A1 (de) * | 2000-10-24 | 2002-04-25 | Leica Microsystems | Vorrichtung zur Behandlung von Objekten |
DE10052832A1 (de) * | 2000-10-24 | 2002-04-25 | Leica Microsystems | Vorrichtung zur Behandlung von Objekten |
DE10052834B4 (de) * | 2000-10-24 | 2019-09-19 | Leica Biosystems Nussloch Gmbh | Verfahren zur Behandlung von Objekten |
EP1243911A1 (de) * | 2001-03-22 | 2002-09-25 | Leica Mikrosysteme GmbH | Vorrichtung zur Gewebepräparation |
EP1248170B1 (en) * | 2001-04-05 | 2009-09-16 | INPECO IP Ltd. | Method for the management of workcell systems based on an automation management system |
US7270785B1 (en) | 2001-11-02 | 2007-09-18 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
WO2003042788A2 (en) * | 2001-11-13 | 2003-05-22 | Chromavision Medical Systems, Inc. | A system for tracking biological samples |
US20040033163A1 (en) * | 2001-11-26 | 2004-02-19 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US6998270B2 (en) | 2001-11-26 | 2006-02-14 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US20030186353A1 (en) * | 2002-04-02 | 2003-10-02 | Page Erickson | Microscopic precision construction of tissue array block |
US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
CA2482441C (en) | 2002-04-15 | 2010-06-22 | Ventana Medical Systems, Inc. | Automated high volume slide staining system |
WO2003091710A1 (en) * | 2002-04-26 | 2003-11-06 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
AU2003249291A1 (en) * | 2002-07-16 | 2004-02-02 | Ventana Medical Systems, Inc. | Tray for automated histochemical processing |
US7850912B2 (en) * | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7584019B2 (en) * | 2003-12-15 | 2009-09-01 | Dako Denmark A/S | Systems and methods for the automated pre-treatment and processing of biological samples |
US7875245B2 (en) * | 2003-05-14 | 2011-01-25 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
AU2003900810A0 (en) * | 2003-02-24 | 2003-03-13 | Vision Biosystems Limited | Method of scheduling |
US8283176B2 (en) | 2004-06-29 | 2012-10-09 | Dako Denmark A/S | Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device |
CA2526126C (en) * | 2003-05-19 | 2012-05-15 | Ventana Medical Systems, Inc. | Electrophoretic in situ tissue staining |
US7642064B2 (en) | 2003-06-24 | 2010-01-05 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest |
DK1636586T3 (da) * | 2003-06-24 | 2009-11-23 | Ventana Med Syst Inc | Enzymkatalyseret metaldeponering til foröget in situ-detektion af immunhistokemisker epitoper og nucleinsyresekvenser |
US20080235055A1 (en) * | 2003-07-17 | 2008-09-25 | Scott Mattingly | Laboratory instrumentation information management and control network |
US7860727B2 (en) | 2003-07-17 | 2010-12-28 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US8719053B2 (en) * | 2003-07-17 | 2014-05-06 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US7767152B2 (en) | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
US7501283B2 (en) * | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US9518899B2 (en) | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
US7744817B2 (en) | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
DE10344284A1 (de) * | 2003-09-24 | 2005-05-04 | Keyneurotek Ag | Vorrichtung und Verfahren zur automatisierten Durchführung von Laborarbeitsschritten |
ATE442576T1 (de) * | 2003-10-24 | 2009-09-15 | Univ Miami | Vereinfachte gewebeverarbeitung |
US8026106B1 (en) | 2003-12-18 | 2011-09-27 | Ventana Medical Systems, Inc. | Removal of mercuric chloride crystals from fixed tissues |
WO2005064309A1 (en) * | 2003-12-23 | 2005-07-14 | Ventana Medical Systems, Inc. | Method and apparatus for efficient thin film fluid |
EP1733240A4 (en) | 2004-03-02 | 2007-08-22 | Dako Denmark As | REAGENT DISPENSING SYSTEM, DISPENSING DEVICE AND CONTAINER FOR BIOLOGICAL COLORING APPARATUS |
US7867443B2 (en) * | 2004-07-23 | 2011-01-11 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
AU2005267018B2 (en) * | 2004-07-23 | 2008-10-23 | Ventana Medical Systems, Inc. | Method and apparatus for applying fluids to a biological sample |
GB0501590D0 (en) * | 2005-01-25 | 2005-03-02 | Ceres Power Ltd | Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode |
US7680559B2 (en) * | 2005-02-08 | 2010-03-16 | Lam Research Corporation | Wafer movement control macros |
EP1877787A2 (en) | 2005-04-21 | 2008-01-16 | Celerus Diagnostics, Inc. | Enhanced fluidic method and apparatus for automated rapid immunohistochemistry |
JP5335420B2 (ja) * | 2005-05-24 | 2013-11-06 | リー エイチ. アングロス, | insitu熱誘導抗原回復・着色装置および方法 |
AU2006312250B2 (en) | 2005-06-28 | 2011-07-07 | The Board Of Regents Of The University Of Oklahoma | Methods for growing and harvesting carbon nanotubes |
KR100749579B1 (ko) * | 2005-09-05 | 2007-08-16 | 삼성광주전자 주식회사 | 교환가능한 복수의 작업모듈을 갖는 이동로봇 시스템 및 그제어방법 |
US7853356B2 (en) * | 2006-04-14 | 2010-12-14 | Fanuc Robotics America, Inc. | Method for optimizing a robot program and a robot system |
US8459509B2 (en) | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US7875242B2 (en) * | 2006-10-17 | 2011-01-25 | Preyas Sarabhai Shah | Slide stainer with multiple heater stations |
DE102007008713B4 (de) * | 2007-02-20 | 2019-07-11 | Leica Biosystems Nussloch Gmbh | Gewebeinfiltrationsvorrichtung |
CA2714600C (en) | 2008-02-29 | 2021-11-02 | Dako Denmark A/S | Systems and methods for tracking and providing workflow information |
US20090298172A1 (en) | 2008-05-28 | 2009-12-03 | Steven Paul Wheeler | Histological specimen treatment apparatus and method |
EP2530025B1 (en) * | 2008-07-25 | 2015-11-04 | F.Hoffmann-La Roche Ag | Alignment element for sample tube racks |
GB2477648B (en) | 2008-08-29 | 2013-02-20 | Lee H Angros | In situ heat induced antigen recovery and staining apparatus and method |
US10184862B2 (en) | 2008-11-12 | 2019-01-22 | Ventana Medical Systems, Inc. | Methods and apparatuses for heating slides carrying specimens |
US10500384B2 (en) * | 2010-01-08 | 2019-12-10 | Wake Forest University Health Sciences | Delivery system |
JP5432816B2 (ja) * | 2010-05-14 | 2014-03-05 | 株式会社日立ハイテクノロジーズ | 自動分析システムおよび装置管理サーバ |
JP5591742B2 (ja) * | 2010-06-30 | 2014-09-17 | シスメックス株式会社 | 検体検査装置の処理能力情報生成装置、検体検査装置、検体検査装置の処理能力情報生成方法、及びコンピュータプログラム |
US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
CA2828705A1 (en) | 2011-03-07 | 2012-09-13 | Wake Forest University Health Sciences | Delivery system |
US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
US8580568B2 (en) | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
US9091621B2 (en) * | 2013-04-05 | 2015-07-28 | GGB Company | Multiple slide processing apparatus |
AU2014363717B2 (en) | 2013-12-13 | 2016-12-22 | Ventana Medical Systems, Inc. | Automated histological processing of biological specimens and associated technology |
JP6432883B2 (ja) * | 2014-11-21 | 2018-12-05 | 国立研究開発法人産業技術総合研究所 | 動作指令生成装置、動作指令生成方法、コンピュータプログラム、及び処理システム |
JP6419547B2 (ja) | 2014-11-21 | 2018-11-07 | 国立研究開発法人産業技術総合研究所 | 動作指令生成装置、動作指令生成方法、コンピュータプログラム、及び処理システム。 |
US10365189B2 (en) | 2015-05-07 | 2019-07-30 | Steven Wheeler | Histological specimen treatment |
CN107850612B (zh) * | 2015-09-11 | 2019-01-01 | 株式会社日立高新技术 | 自动分析装置 |
CN118131667A (zh) | 2017-01-27 | 2024-06-04 | 隆萨有限公司 | 动态控制自动化系统 |
CN109253874B (zh) * | 2018-10-19 | 2020-03-31 | 日照职业技术学院 | 一种机器人手臂灵活度检测装置 |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3665148A (en) * | 1971-04-07 | 1972-05-23 | Gen Motors Corp | Six-axis manipulator |
US4058367A (en) | 1976-05-19 | 1977-11-15 | Gilford Instrument Laboratories Inc. | Automatic asynchronous fluid processing apparatus |
SU603577A1 (ru) * | 1976-07-06 | 1978-04-25 | Ордена Ленина, Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Завод "Ростсельмаш" | Промышленный робот |
US4087248A (en) * | 1976-07-26 | 1978-05-02 | Miles Laughton E | Multiple assay machine and method |
JPS5514157A (en) * | 1978-07-14 | 1980-01-31 | Shin Meiwa Ind Co Ltd | Automatic welder |
JPS55136958A (en) | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
US5037484A (en) * | 1981-04-20 | 1991-08-06 | Alcon Laboratories, Inc. | Cleaning agent for optical surfaces |
IT1144709B (it) * | 1981-05-15 | 1986-10-29 | Dea Spa | Sistema di misura dimensionale servito da una pluralita di bracci operativi e controllato da un sistema a calcolatore |
US4384193A (en) * | 1981-06-09 | 1983-05-17 | Immulok, Inc. | Incubating device for specimen mounted on glass slides in immunoassays |
JPS5848836A (ja) * | 1981-09-18 | 1983-03-22 | Toa Medical Electronics Co Ltd | 光学式自動分析測定装置 |
US4727409A (en) | 1982-04-12 | 1988-02-23 | Signetics Corporation | Programmable read-only memory formed with opposing PN diodes |
EP0122772B1 (en) * | 1983-04-15 | 1988-08-17 | Science and Technology Agency, Minister's Secretariat, Director of Finance Division | Chemical manipulator |
GB2143205B (en) * | 1983-07-15 | 1986-07-16 | Leicester Polytechnic | Robots |
JPS6111293A (ja) | 1984-06-27 | 1986-01-18 | Kanzaki Paper Mfg Co Ltd | 熱転写記録用受像シ−ト |
JPS6149205A (ja) * | 1984-08-16 | 1986-03-11 | Seiko Instr & Electronics Ltd | ロボツト制御方式 |
JPH0690211B2 (ja) | 1984-09-21 | 1994-11-14 | オリンパス光学工業株式会社 | 免疫学的分析装置およびその方法 |
US4952518A (en) * | 1984-10-01 | 1990-08-28 | Cetus Corporation | Automated assay machine and assay tray |
US4727494A (en) * | 1985-01-01 | 1988-02-23 | Zymark Corporation | Computerized robot control system with scheduling feature |
US4648023A (en) | 1985-05-23 | 1987-03-03 | Powell Roger A | Method for resource allocation for the manufacture of a product |
US4719087A (en) * | 1985-07-01 | 1988-01-12 | Baxter Travenol Laboratories, Inc. | Tray for analyzing system |
US4731335A (en) | 1985-09-13 | 1988-03-15 | Fisher Scientific Company | Method for treating thin samples on a surface employing capillary flow |
US5023187A (en) | 1985-09-13 | 1991-06-11 | Fisher Scientific Company | Method and device for accelerated treatment of thin sample on surface |
US4670974A (en) | 1985-11-06 | 1987-06-09 | Westinghouse Electric Corp. | Windshield insertion system for a vehicle on a moving conveyor apparatus |
US4678752A (en) | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
GB8605324D0 (en) * | 1986-03-04 | 1986-04-09 | Rank Taylor Hobson Ltd | Metrological apparatus |
US4843566A (en) * | 1986-03-07 | 1989-06-27 | Hewlett-Packard Company | Robot motion control system |
EP0261202A1 (en) * | 1986-03-26 | 1988-03-30 | Beckman Instruments, Inc. | Automated multi-purposse analytical chemistry processing center and laboratory work station |
US4835711A (en) * | 1986-05-30 | 1989-05-30 | Zymark Corporation | Quickly reconfigurable robotic system |
FR2600166B1 (fr) | 1986-06-17 | 1988-10-07 | Rhone Poulenc Rech | Procede et dispositif de prise en charge et d'analyses automatiques d'echantillons de produits amenes de facon aleatoire |
EP0255026A3 (en) * | 1986-07-23 | 1988-10-19 | Takeda Chemical Industries, Ltd. | Automatic analysis method and apparatus for enzyme reaction |
JP2533495B2 (ja) * | 1986-07-25 | 1996-09-11 | 株式会社日立製作所 | ワ−クスケジユ−リング方法及び装置 |
DE3634976C2 (de) * | 1986-10-14 | 1997-09-11 | Tiyoda Seisakusho Koushoku Kk | Vorrichtung zur automatischen Färbung von Präparaten zur mikroskopischen Untersuchung |
GR871619B (en) | 1986-10-31 | 1988-03-03 | Genetic Systems Corp | Automated patient sample analysis instrument |
EP0275826A1 (en) * | 1986-12-16 | 1988-07-27 | Ciba-Geigy Ag | Control system for a sample preparation system |
JPS63208761A (ja) | 1987-02-25 | 1988-08-30 | Chiyoda Seisakusho:Kk | 顕微鏡標本の自動染色装置により複数種類の染色方法を同時に行なう手順を求める方法及び装置 |
US4954237A (en) * | 1987-03-16 | 1990-09-04 | Helena Laboratories | Automatic electrophoresis apparatus |
US5002736A (en) | 1987-03-31 | 1991-03-26 | Fisher Scientific Co. | Microscope slide and slide assembly |
US4803048A (en) * | 1987-04-02 | 1989-02-07 | Nason Frederic L | Laboratory kit |
US5148370A (en) * | 1987-06-17 | 1992-09-15 | The Standard Oil Company | Expert system and method for batch production scheduling and planning |
JPS645779A (en) * | 1987-06-29 | 1989-01-10 | Fanuc Ltd | Robot arrangement examination system |
US4869813A (en) * | 1987-07-02 | 1989-09-26 | Northrop Corporation | Drill inspection and sorting method and apparatus |
US4979093A (en) * | 1987-07-16 | 1990-12-18 | Cavro Scientific Instruments | XYZ positioner |
US4896269A (en) * | 1988-02-29 | 1990-01-23 | General Electric Company | Job shop scheduling and production method and apparatus |
FR2630216A1 (fr) * | 1988-04-14 | 1989-10-20 | Ibal | Installation robotisee d'analyses, notamment medicales |
US4929619A (en) * | 1988-07-14 | 1990-05-29 | Thames Pharmacal Co., Inc. | Anti-infective methods and compositions |
US5229074A (en) * | 1988-07-25 | 1993-07-20 | Precision Systems, Inc. | Automatic multiple-sample multiple-reagent chemical analyzer |
EP0353589B1 (en) | 1988-08-02 | 1996-02-07 | Abbott Laboratories | Apparatus and method for providing assay calibration data |
US5016170A (en) * | 1988-09-22 | 1991-05-14 | Pollalis Spiro N | Task management |
US5122959A (en) | 1988-10-28 | 1992-06-16 | Automated Dispatch Services, Inc. | Transportation dispatch and delivery tracking system |
EP0387409B1 (en) * | 1989-03-15 | 1993-10-27 | Hewlett-Packard Company | Pre-injection chromatographic sample sequencer |
JPH02284885A (ja) * | 1989-04-27 | 1990-11-22 | Nissan Motor Co Ltd | ワーク位置決め装置の位置教示方法 |
US5281394A (en) * | 1989-07-21 | 1994-01-25 | Icn Biomedicals, Inc. | Data collection and sample handling apparatus |
JPH0363568A (ja) | 1989-07-31 | 1991-03-19 | Mitsui Toatsu Chem Inc | 液状樹脂自動分析におけるモニタリング方式 |
US4975250A (en) | 1989-08-21 | 1990-12-04 | Fisher Scientific Co. | Aligned slideholder and assembly |
US5040123A (en) | 1989-09-08 | 1991-08-13 | General Motors Corporation | Expert system scheduler |
JPH0650460B2 (ja) * | 1989-10-17 | 1994-06-29 | アプライド バイオシステムズ インコーポレイテッド | ロボットインターフェース |
US5233533A (en) | 1989-12-19 | 1993-08-03 | Symmetrix, Inc. | Scheduling method and apparatus |
US5355304A (en) * | 1990-01-30 | 1994-10-11 | Demoranville Victoria E | Clinical laboratory work-flow system which semi-automates validated immunoassay and electrophoresis protocols |
US5595707A (en) * | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
US5225325A (en) * | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
US5168441A (en) * | 1990-05-30 | 1992-12-01 | Allen-Bradley Company, Inc. | Methods for set up and programming of machine and process controllers |
US5272093A (en) * | 1990-08-02 | 1993-12-21 | Miles Inc. | Reagent containment and delivery tray and method of use |
US5282149A (en) * | 1991-06-03 | 1994-01-25 | Abbott Laboratories | Adaptive scheduling system and method for a biological analyzer with reproducible operation time periods |
US5576215A (en) | 1991-06-03 | 1996-11-19 | Abbott Laboratories | Adaptive scheduling system and method for operating a biological sample analyzer with variable interval periods |
US5246665A (en) | 1991-06-03 | 1993-09-21 | Abbott Laboratories | Heat and air flow control for assay carrier |
US5402350A (en) * | 1991-06-28 | 1995-03-28 | Texas Instruments Incorporated | Scheduling for multi-task manufacturing equipment |
US5355439A (en) * | 1991-08-05 | 1994-10-11 | Bio Tek Instruments | Method and apparatus for automated tissue assay |
US5696887A (en) * | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
EP0531811B1 (en) * | 1991-08-30 | 1997-04-23 | Canon Kabushiki Kaisha | Hand mechanism for robot |
IT1260447B (it) * | 1992-01-27 | 1996-04-09 | Procedimento e apparecchiatura per l'automazione integrale di un laboratorio di analisi | |
US5376313A (en) * | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
US5646049A (en) * | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
US5380487A (en) * | 1992-05-05 | 1995-01-10 | Pasteur Sanofi Diagnostics | Device for automatic chemical analysis |
US5352612A (en) * | 1993-02-09 | 1994-10-04 | Baxter Diagnostics Inc. | Method and apparatus for the stepwise movement of items |
US5479581A (en) * | 1993-12-30 | 1995-12-26 | Storage Technology Corporation | Multiple library media exchange system and method |
US5578270A (en) * | 1995-03-24 | 1996-11-26 | Becton Dickinson And Company | System for nucleic acid based diagnostic assay |
US5737498A (en) * | 1995-07-11 | 1998-04-07 | Beckman Instruments, Inc. | Process automation method and apparatus |
US5975740A (en) * | 1996-05-28 | 1999-11-02 | Applied Materials, Inc. | Apparatus, method and medium for enhancing the throughput of a wafer processing facility using a multi-slot cool down chamber and a priority transfer scheme |
US5909674A (en) * | 1996-12-23 | 1999-06-01 | Philips Electronics North America Corp. | Method for optimizing the layout and charge maps of a flowline of pick and place machines |
US6068393A (en) * | 1997-11-05 | 2000-05-30 | Zymark Corporation | Robotic system for processing chemical products |
-
1994
- 1994-05-31 US US08/252,282 patent/US5696887A/en not_active Expired - Lifetime
-
1995
- 1995-05-17 WO PCT/US1995/006156 patent/WO1995033240A1/en not_active Application Discontinuation
- 1995-05-17 EP EP95921270A patent/EP0804730A1/en not_active Withdrawn
- 1995-05-17 CA CA002191776A patent/CA2191776A1/en not_active Abandoned
- 1995-05-17 JP JP8500922A patent/JPH10504892A/ja not_active Ceased
- 1995-05-17 AU AU26389/95A patent/AU2638995A/en not_active Abandoned
-
1996
- 1996-06-21 US US08/668,377 patent/US5758033A/en not_active Expired - Lifetime
- 1996-06-21 US US08/669,009 patent/US5737499A/en not_active Expired - Lifetime
-
1997
- 1997-12-05 US US08/985,604 patent/US5875286A/en not_active Expired - Lifetime
-
1998
- 1998-04-28 US US09/067,719 patent/US6594537B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5758033A (en) | 1998-05-26 |
WO1995033240A1 (en) | 1995-12-07 |
US5696887A (en) | 1997-12-09 |
US6594537B1 (en) | 2003-07-15 |
JPH10504892A (ja) | 1998-05-12 |
EP0804730A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-11-05 |
US5875286A (en) | 1999-02-23 |
EP0804730A1 (en) | 1997-11-05 |
US5737499A (en) | 1998-04-07 |
AU2638995A (en) | 1995-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2191776A1 (en) | Automated tissue assay using standardized chemicals and packages | |
EP0600939B1 (en) | Method and apparatus for automated tissue assay | |
US5930461A (en) | Method and apparatus for automated tissue assay | |
EP1247084B1 (en) | Method and apparatus for automatic tissue staining | |
AU2003301103B2 (en) | Advanced programmed sample processing system and methods of biological slide processing | |
EP1446649B1 (en) | Method and apparatus for automatic tissue staining | |
EP1514089B1 (en) | Biological reaction apparatus with draining mechanism | |
JP5658226B2 (ja) | スライド大量自動処理システム | |
US6349264B1 (en) | Method and apparatus for automatic tissue staining | |
EP2780688B1 (en) | Biological sample treatment apparatus | |
US20030087446A1 (en) | Apparatus, system, and method of archival and retrieval of samples | |
EP1449147A2 (en) | Archive and analysis system and method | |
JP2002323500A (ja) | 自動連続ランダム・アクセス分析システムおよびその構成要素 | |
EP3910320B1 (en) | Computer-implemented method and system for spectroscopic analysis of biological material | |
WO2003039749A2 (en) | Sample carrier comprising a structural array for archiving sample material | |
CN117761327A (zh) | 一种快速研发膜材料的自动化合成测试系统和方法 | |
CA1336653C (en) | Method and apparatus for treating thin sample on a surface employing capillary flow |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |