CA2178745A1 - Nouveau gene suppresseur de tumeur - Google Patents

Nouveau gene suppresseur de tumeur

Info

Publication number
CA2178745A1
CA2178745A1 CA002178745A CA2178745A CA2178745A1 CA 2178745 A1 CA2178745 A1 CA 2178745A1 CA 002178745 A CA002178745 A CA 002178745A CA 2178745 A CA2178745 A CA 2178745A CA 2178745 A1 CA2178745 A1 CA 2178745A1
Authority
CA
Canada
Prior art keywords
protein
nuc
vector
cells
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002178745A
Other languages
English (en)
Inventor
Wen-Hwa Lee
Phang-Lang Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2178745A1 publication Critical patent/CA2178745A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne une séquence d'ADN isolée et purifiée codant une protéine de fixation de Rb comprenant une sous-séquence présentant une homologie d'au moins 60 % avec neuf répétitions tétratricopeptidiques au niveau de l'extrémité terminale-C, à condition que la séquence ne code ni la protéine de levure nuc 2 de <u>S.pombe</u>, ni la protéine bimA d'<u>aspergillus nidulans</u>, ni la protéine de levure CDC27 <u>S. cerevisiae</u>, des vecteurs contenant ledit ADN, et des sondes à ADN basées sur ledit ADN, ainsi que des méthodes thérapeutiques dans lesquelles lesdits ADN et vecteurs sont utilisés. L'invention porte également sur des protéines codées par ledit ADN, des méthodes thérapeutiques dans lesquelles lesdites protéines sont utilisées, et des méthodes d'expression desdites protéines. L'invention se rapporte aussi à des anticorps dirigés contre lesdites protéines, des hybridomes produisant lesdits anticorps monoclonaux, et des méthodes diagnostiques dans lesquelles lesdits anticorps sont utilisés.
CA002178745A 1993-12-20 1994-12-20 Nouveau gene suppresseur de tumeur Abandoned CA2178745A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17058693A 1993-12-20 1993-12-20
US08/170,586 1993-12-20

Publications (1)

Publication Number Publication Date
CA2178745A1 true CA2178745A1 (fr) 1995-06-29

Family

ID=22620468

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002178745A Abandoned CA2178745A1 (fr) 1993-12-20 1994-12-20 Nouveau gene suppresseur de tumeur

Country Status (14)

Country Link
EP (1) EP0735889A4 (fr)
JP (1) JPH09510343A (fr)
CN (1) CN1138295A (fr)
AU (1) AU1517495A (fr)
BR (1) BR9408357A (fr)
CA (1) CA2178745A1 (fr)
CZ (1) CZ178396A3 (fr)
FI (1) FI962558A0 (fr)
HU (1) HUT74413A (fr)
NO (1) NO962596L (fr)
NZ (1) NZ278745A (fr)
PL (1) PL315172A1 (fr)
SK (1) SK76896A3 (fr)
WO (1) WO1995017198A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747282A (en) * 1994-08-12 1998-05-05 Myraid Genetics, Inc. 17Q-linked breast and ovarian cancer susceptibility gene
CN1054399C (zh) * 1997-11-07 2000-07-12 中国科学院上海生物化学研究所 一个与抗癌基因p53相作用的人类新基因p53bp3
AU771619B2 (en) 1998-06-30 2004-04-01 Genset S.A. A nucleic acid encoding a retinoblastoma binding protein (RBP-7) and polymorphic markers associated with said nucleic acid
CA2374386A1 (fr) * 1999-07-05 2001-01-11 Cropdesign N.V. Proteines vegetales
WO2001029229A1 (fr) * 1999-10-18 2001-04-26 Shanghai Bio Road Gene Development Ltd. Nouveau polypeptide, proteine humaine 20 de liaison de retinoblastome et polynucleotide le codant
CN1333255A (zh) * 2000-07-07 2002-01-30 上海博德基因开发有限公司 一种新的多肽——人视网膜瘤结合蛋白19.91和编码这种多肽的多核苷酸

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology

Also Published As

Publication number Publication date
SK76896A3 (en) 1997-02-05
EP0735889A1 (fr) 1996-10-09
NO962596L (no) 1996-08-19
CN1138295A (zh) 1996-12-18
HU9601686D0 (en) 1996-08-28
WO1995017198A1 (fr) 1995-06-29
BR9408357A (pt) 1997-08-26
NO962596D0 (no) 1996-06-19
CZ178396A3 (en) 1997-03-12
EP0735889A4 (fr) 1999-04-14
AU1517495A (en) 1995-07-10
PL315172A1 (en) 1996-10-14
HUT74413A (en) 1996-12-30
NZ278745A (en) 1997-09-22
FI962558A (fi) 1996-06-19
FI962558A0 (fi) 1996-06-19
JPH09510343A (ja) 1997-10-21

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Legal Events

Date Code Title Description
FZDE Discontinued