CA2169635C - Methode, compositions et dispositifs pour administrer des polynucleotides nus codant des peptides biologiquement actifs - Google Patents
Methode, compositions et dispositifs pour administrer des polynucleotides nus codant des peptides biologiquement actifs Download PDFInfo
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- CA2169635C CA2169635C CA002169635A CA2169635A CA2169635C CA 2169635 C CA2169635 C CA 2169635C CA 002169635 A CA002169635 A CA 002169635A CA 2169635 A CA2169635 A CA 2169635A CA 2169635 C CA2169635 C CA 2169635C
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Abstract
L'invention concerne des procédés d'introduction de peptides ayant une activité biologique dans un hôte (en particulier en vue d'une vaccination ou de l'expression transitoire d'un peptide à usage thérapeutique) par l'administration de polynucléotides qui assurent le codage pour le peptide. Dans la plupart des formes de réalisation, les polynucléotides sont nus au sens où ils ne sont ni complexés en préparations colloïdales, ni associés à un vecteur d'intégration génomique. Dans une forme de réalisation, les polynucléotides nus sont administrés à des tissus hôtes dans lesquels la concentration en cellules présentant des antigènes est plus élevée que dans d'autre tissus hôtes. On pense que les polynucléotides sont absorbés et exprimés au niveau local, systémique et/ou en des sites distants de leur point d'entrée dans l'hôte. Dans une autre forme de réalisation, les polynucléotides expriment des peptides efficaces pour retarder, traiter et prévenir les maladies liées au vieillissement et la perte de la résistance aux maladies chez des mammifères. Dans cette forme de réalisation, des taux subthérapeutiques des peptides sont exprimés à des stades appropriés du développement de l'hôte. Des dispositifs et des compositions utilisables dans les procédés selon l'invention sont également décrits.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11244093A | 1993-08-26 | 1993-08-26 | |
US08/112,440 | 1993-08-26 | ||
PCT/US1994/009661 WO1995005853A1 (fr) | 1993-08-26 | 1994-08-25 | Procede, compositions et dispositifs pour l'administration de polynucleotides nus qui codent des peptides a activite biologique |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2169635A1 CA2169635A1 (fr) | 1995-03-02 |
CA2169635C true CA2169635C (fr) | 2002-11-12 |
Family
ID=22343912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002169635A Expired - Fee Related CA2169635C (fr) | 1993-08-26 | 1994-08-25 | Methode, compositions et dispositifs pour administrer des polynucleotides nus codant des peptides biologiquement actifs |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0714308A4 (fr) |
JP (2) | JPH09501936A (fr) |
AU (1) | AU705889B2 (fr) |
CA (1) | CA2169635C (fr) |
MX (1) | MX9406552A (fr) |
WO (1) | WO1995005853A1 (fr) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0500799B1 (fr) | 1989-11-16 | 1998-01-14 | Duke University | Transformation de cellules épidermales tissulaires animales à l'aide de particle |
US5849719A (en) | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
US5804566A (en) * | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
FR2711670B1 (fr) | 1993-10-22 | 1996-01-12 | Pasteur Institut | Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite. |
US6727230B1 (en) | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
WO1998045408A2 (fr) * | 1996-04-10 | 1998-10-15 | Heska Corporation | Nouvelles proteines de salive d'ectoparasite et appareil permettant de recueillir ces proteines |
US20020169104A1 (en) | 1997-05-01 | 2002-11-14 | Glenn Frank | Novel ectoparasite saliva proteins and apparatus to collect such proteins |
GB9505777D0 (en) * | 1995-03-22 | 1995-05-10 | Zeneca Ltd | Process |
DE19512142A1 (de) * | 1995-03-31 | 1996-10-02 | Immuno Ag | Infektiöser cDNA-Klon des Tick-Borne Enzephalitis (TBE)-Virus, davon abgeleiteter rekombinanter Impfstoff und Herstellung desselben sowie ein pharmazeutisches Produkt, das eine replizierbare Nukleinsäure enthält |
US5703057A (en) * | 1995-04-07 | 1997-12-30 | Board Of Regents The University Of Texas System | Expression library immunization |
GB9709900D0 (en) | 1997-05-15 | 1997-07-09 | Microbiological Res Authority | Microencapsulated DNA for vaccination and gene therapy |
EP0862419B2 (fr) | 1995-11-09 | 2010-11-17 | Microbiological Research Authority | Adn microencapsule s'appliquant dans des procedes de vaccination et de therapie genique |
US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
WO1998008947A1 (fr) * | 1995-12-19 | 1998-03-05 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Amelioration de l'immunisation a l'adn obtenu a l'aide de cytokines |
EP0871747A1 (fr) * | 1996-01-02 | 1998-10-21 | Chiron Viagene, Inc. | Immunostimulation a mediation par cellules dendritiques modifiees par des genes |
ES2184990T3 (es) * | 1996-02-12 | 2003-04-16 | Ml Lab Plc | Nuevos metodos de vacunacion y vacunas para los mismos que comprenden un acido nucleico que codifica un primer epitope y un peptido que contiene un segundo epitope. |
US6689757B1 (en) | 1996-02-12 | 2004-02-10 | M.L. Laboratories Plc | Methods for vaccination and vaccines therefor |
AU1865297A (en) * | 1996-03-08 | 1997-09-22 | University Of Toronto, The | Methods and nucleic immunogenic compositions encoding antigens and co-stimulatory molecules for immunization |
TW480282B (en) * | 1996-04-24 | 2002-03-21 | Ren Wen Corp | Recombinant eucaryotic vector containing allergen gene and use of preventing and treating allergic disease thereof |
ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
EP0855184A1 (fr) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
US6214806B1 (en) | 1997-02-28 | 2001-04-10 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CPC dinucleotide in the treatment of LPS-associated disorders |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6339068B1 (en) | 1997-05-20 | 2002-01-15 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
US6348450B1 (en) | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
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-
1994
- 1994-08-25 EP EP94926603A patent/EP0714308A4/fr not_active Withdrawn
- 1994-08-25 WO PCT/US1994/009661 patent/WO1995005853A1/fr active Application Filing
- 1994-08-25 CA CA002169635A patent/CA2169635C/fr not_active Expired - Fee Related
- 1994-08-25 JP JP7507766A patent/JPH09501936A/ja not_active Ceased
- 1994-08-25 AU AU76391/94A patent/AU705889B2/en not_active Ceased
- 1994-08-26 MX MX9406552A patent/MX9406552A/es not_active IP Right Cessation
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2004
- 2004-06-07 JP JP2004168972A patent/JP2004331668A/ja active Pending
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AU705889B2 (en) | 1999-06-03 |
CA2169635A1 (fr) | 1995-03-02 |
EP0714308A1 (fr) | 1996-06-05 |
MX9406552A (es) | 1997-02-28 |
WO1995005853A1 (fr) | 1995-03-02 |
JP2004331668A (ja) | 2004-11-25 |
JPH09501936A (ja) | 1997-02-25 |
EP0714308A4 (fr) | 1998-07-29 |
AU7639194A (en) | 1995-03-21 |
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