CA2141691C - Formes posologiques solides possedant un profil de liberation prolongee en deux etapes; procede de fabrication - Google Patents

Formes posologiques solides possedant un profil de liberation prolongee en deux etapes; procede de fabrication Download PDF

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Publication number
CA2141691C
CA2141691C CA002141691A CA2141691A CA2141691C CA 2141691 C CA2141691 C CA 2141691C CA 002141691 A CA002141691 A CA 002141691A CA 2141691 A CA2141691 A CA 2141691A CA 2141691 C CA2141691 C CA 2141691C
Authority
CA
Canada
Prior art keywords
water
casein
salt
insoluble
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002141691A
Other languages
English (en)
Other versions
CA2141691A1 (fr
Inventor
Eberhard Nurnberg
Stefan Ritsert
Erhard Seiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Merz and Co GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz and Co GmbH and Co KG filed Critical Merz and Co GmbH and Co KG
Publication of CA2141691A1 publication Critical patent/CA2141691A1/fr
Application granted granted Critical
Publication of CA2141691C publication Critical patent/CA2141691C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002141691A 1992-08-04 1993-08-04 Formes posologiques solides possedant un profil de liberation prolongee en deux etapes; procede de fabrication Expired - Lifetime CA2141691C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4225730A DE4225730C2 (de) 1992-08-04 1992-08-04 Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
DEP4225730.1 1992-08-04
PCT/EP1993/002074 WO1994003158A1 (fr) 1992-08-04 1993-08-04 Formes galeniques pharmaceutiques solides a profil de liberation prolonge en deux etapes et leur production

Publications (2)

Publication Number Publication Date
CA2141691A1 CA2141691A1 (fr) 1994-02-17
CA2141691C true CA2141691C (fr) 2002-04-09

Family

ID=6464804

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002141691A Expired - Lifetime CA2141691C (fr) 1992-08-04 1993-08-04 Formes posologiques solides possedant un profil de liberation prolongee en deux etapes; procede de fabrication

Country Status (17)

Country Link
US (1) US5382601A (fr)
EP (1) EP0582186B1 (fr)
JP (1) JP3560244B2 (fr)
CN (1) CN1086708A (fr)
AT (1) ATE176866T1 (fr)
AU (1) AU669731B2 (fr)
CA (1) CA2141691C (fr)
DE (2) DE4225730C2 (fr)
DK (1) DK0582186T3 (fr)
ES (1) ES2128369T3 (fr)
GR (1) GR3030227T3 (fr)
IL (1) IL106580A (fr)
LT (1) LT3201B (fr)
LV (1) LV10182B (fr)
MX (1) MX9304675A (fr)
WO (1) WO1994003158A1 (fr)
ZA (1) ZA935614B (fr)

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US6294583B1 (en) 1998-01-13 2001-09-25 Synchroneuron, Llc Methods of treating tardive dyskinesia and other movement disorders
US5952389A (en) * 1998-01-13 1999-09-14 Synchroneuron Methods of treating tardive dyskinesia and other movement disorders
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DE19814257A1 (de) 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
US6444702B1 (en) 2000-02-22 2002-09-03 Neuromolecular, Inc. Aminoadamantane derivatives as therapeutic agents
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US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
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US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
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US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
US20060160852A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Composition containing anti-dementia drug
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CA2604052C (fr) * 2005-04-06 2014-07-08 Adamas Pharmaceuticals, Inc. Methode et compositions de traitement des affections du snc
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WO2006119329A2 (fr) * 2005-05-02 2006-11-09 Combinatorx, Incorporated Compositions et procedes pour traiter des maladies neurodegeneratives
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Also Published As

Publication number Publication date
LV10182A (lv) 1994-10-20
DE4225730A1 (de) 1994-02-10
ES2128369T3 (es) 1999-05-16
AU669731B2 (en) 1996-06-20
LV10182B (en) 1995-04-20
DE59309388D1 (de) 1999-04-01
DE4225730C2 (de) 2003-04-30
ZA935614B (en) 1995-02-03
AU4706993A (en) 1994-03-03
CA2141691A1 (fr) 1994-02-17
JP3560244B2 (ja) 2004-09-02
EP0582186A1 (fr) 1994-02-09
CN1086708A (zh) 1994-05-18
DK0582186T3 (da) 1999-09-27
EP0582186B1 (fr) 1999-02-24
GR3030227T3 (en) 1999-08-31
IL106580A0 (en) 1993-12-08
JPH07509479A (ja) 1995-10-19
IL106580A (en) 1998-02-08
WO1994003158A1 (fr) 1994-02-17
MX9304675A (es) 1994-03-31
LTIP839A (lt) 1994-08-25
ATE176866T1 (de) 1999-03-15
US5382601A (en) 1995-01-17
LT3201B (en) 1995-03-27

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