CA2141214A1 - Hydroxamic acid derivatives and their use as anti-inflammatory compounds - Google Patents
Hydroxamic acid derivatives and their use as anti-inflammatory compoundsInfo
- Publication number
- CA2141214A1 CA2141214A1 CA002141214A CA2141214A CA2141214A1 CA 2141214 A1 CA2141214 A1 CA 2141214A1 CA 002141214 A CA002141214 A CA 002141214A CA 2141214 A CA2141214 A CA 2141214A CA 2141214 A1 CA2141214 A1 CA 2141214A1
- Authority
- CA
- Canada
- Prior art keywords
- enyl
- methylprop
- phenyl
- cyanophenoxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9215921.9 | 1992-07-27 | ||
GB929215921A GB9215921D0 (en) | 1992-07-27 | 1992-07-27 | Anti-inflammatory compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2141214A1 true CA2141214A1 (en) | 1994-02-03 |
Family
ID=10719360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002141214A Abandoned CA2141214A1 (en) | 1992-07-27 | 1993-07-27 | Hydroxamic acid derivatives and their use as anti-inflammatory compounds |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0652864A1 (de) |
JP (1) | JPH07509462A (de) |
AU (1) | AU672810B2 (de) |
CA (1) | CA2141214A1 (de) |
GB (1) | GB9215921D0 (de) |
IL (1) | IL106472A0 (de) |
MX (1) | MX9304503A (de) |
TW (1) | TW246670B (de) |
WO (1) | WO1994002448A1 (de) |
ZA (1) | ZA935378B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995014681A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | Isoxazoline compounds as antiinflammatory agents |
US5696141A (en) * | 1994-03-09 | 1997-12-09 | Pfizer Inc. | Isoxazoline compounds as 5-lipoxygenase inhibitors |
WO1996023772A1 (fr) * | 1995-02-02 | 1996-08-08 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree |
JP2000504723A (ja) | 1996-02-13 | 2000-04-18 | ジー.ディー.サール アンド カンパニー | シクロオキシゲナーゼ―2阻害剤および5―リポキシゲナーゼ阻害剤投与の免疫抑制効果 |
WO1997029774A1 (en) | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor |
AU2250097A (en) | 1996-02-13 | 1997-09-02 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist |
UA65542C2 (uk) * | 1996-06-25 | 2004-04-15 | Сефалон, Інк. | Спосіб пригнічення надлишкового продукування фактора некрозу пухлин альфа , спосіб полегшення шкідливих ефектів надлишкового продукування фактора некрозу пухлин альфа та спосіб лікування запального стану або захворювання, пов'язаного з фактором некрозу пухлин. |
NZ501166A (en) * | 1997-07-31 | 2001-12-21 | Abbott Lab | Reverse hydroxamate-containing compounds and their use as inhibitors of matrix metalloproteinases |
US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
WO2000044712A1 (en) * | 1999-01-27 | 2000-08-03 | Abbott Laboratories | N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases |
SE0103325D0 (sv) | 2001-10-04 | 2001-10-04 | Astrazeneca Ab | Novel compounds |
JP5452237B2 (ja) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ215487A (en) * | 1985-03-16 | 1990-01-29 | Wellcome Found | Aryl derivatives, pharmaceutical compositions thereof and preservation of cut flowers |
PL154186B1 (en) * | 1987-07-15 | 1991-07-31 | Wellcome Found | Method for manufacturing arylic derivatives of the hydroxamic acid |
EP0540673B1 (de) * | 1990-07-25 | 1996-10-16 | Abbott Laboratories | Acetylenderivate mit lipoxygenase inhibitorischer wirkung |
JPH06256285A (ja) * | 1990-12-11 | 1994-09-13 | Pfizer Pharmaceut Co Ltd | ヒドロキサム酸誘導体およびその用途 |
-
1992
- 1992-07-27 GB GB929215921A patent/GB9215921D0/en active Pending
-
1993
- 1993-07-26 MX MX9304503A patent/MX9304503A/es unknown
- 1993-07-26 ZA ZA935378A patent/ZA935378B/xx unknown
- 1993-07-26 IL IL106472A patent/IL106472A0/xx unknown
- 1993-07-26 TW TW082105933A patent/TW246670B/zh active
- 1993-07-27 EP EP93917925A patent/EP0652864A1/de not_active Withdrawn
- 1993-07-27 AU AU47170/93A patent/AU672810B2/en not_active Ceased
- 1993-07-27 JP JP6504325A patent/JPH07509462A/ja active Pending
- 1993-07-27 WO PCT/GB1993/001585 patent/WO1994002448A1/en not_active Application Discontinuation
- 1993-07-27 CA CA002141214A patent/CA2141214A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU4717093A (en) | 1994-02-14 |
EP0652864A1 (de) | 1995-05-17 |
GB9215921D0 (en) | 1992-09-09 |
MX9304503A (es) | 1994-04-29 |
ZA935378B (en) | 1995-01-26 |
IL106472A0 (en) | 1993-11-15 |
AU672810B2 (en) | 1996-10-17 |
JPH07509462A (ja) | 1995-10-19 |
TW246670B (de) | 1995-05-01 |
WO1994002448A1 (en) | 1994-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |