CA2134898A1 - Compositions et methodes de vaccination contre les coronavirus - Google Patents
Compositions et methodes de vaccination contre les coronavirusInfo
- Publication number
- CA2134898A1 CA2134898A1 CA002134898A CA2134898A CA2134898A1 CA 2134898 A1 CA2134898 A1 CA 2134898A1 CA 002134898 A CA002134898 A CA 002134898A CA 2134898 A CA2134898 A CA 2134898A CA 2134898 A1 CA2134898 A1 CA 2134898A1
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- CA
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- Prior art keywords
- thr
- val
- leu
- ser
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 210000004898 n-terminal fragment Anatomy 0.000 description 1
- 238000002402 nanowire electron scattering Methods 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- QHGUCRYDKWKLMG-UHFFFAOYSA-N octopamine Chemical compound NCC(O)C1=CC=C(O)C=C1 QHGUCRYDKWKLMG-UHFFFAOYSA-N 0.000 description 1
- 229960001576 octopamine Drugs 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 101150098295 pel1 gene Proteins 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
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- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 108010084572 phenylalanyl-valine Proteins 0.000 description 1
- 108010024607 phenylalanylalanine Proteins 0.000 description 1
- SXADIBFZNXBEGI-UHFFFAOYSA-N phosphoramidous acid Chemical compound NP(O)O SXADIBFZNXBEGI-UHFFFAOYSA-N 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 108010077112 prolyl-proline Proteins 0.000 description 1
- 208000009305 pseudorabies Diseases 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000010814 radioimmunoprecipitation assay Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229940000207 selenious acid Drugs 0.000 description 1
- MCAHWIHFGHIESP-UHFFFAOYSA-N selenous acid Chemical compound O[Se](O)=O MCAHWIHFGHIESP-UHFFFAOYSA-N 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 108010048818 seryl-histidine Proteins 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 108010080629 tryptophan-leucine Proteins 0.000 description 1
- 108010038745 tryptophylglycine Proteins 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88217192A | 1992-05-08 | 1992-05-08 | |
US07/882,171 | 1992-05-08 | ||
PCT/US1993/004384 WO1993023422A1 (fr) | 1992-05-08 | 1993-05-07 | Compositions et procedes de vaccination contre les coronavirus |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2134898A1 true CA2134898A1 (fr) | 1993-11-25 |
Family
ID=25380027
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002135201A Abandoned CA2135201A1 (fr) | 1992-05-08 | 1993-05-07 | Vaccin universel contre le coronavirus |
CA002134898A Abandoned CA2134898A1 (fr) | 1992-05-08 | 1993-05-07 | Compositions et methodes de vaccination contre les coronavirus |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002135201A Abandoned CA2135201A1 (fr) | 1992-05-08 | 1993-05-07 | Vaccin universel contre le coronavirus |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP0640096A4 (fr) |
JP (2) | JPH08501931A (fr) |
AU (2) | AU678971B2 (fr) |
CA (2) | CA2135201A1 (fr) |
WO (2) | WO1993023421A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
US5484719A (en) | 1991-08-26 | 1996-01-16 | Edible Vaccines, Inc. | Vaccines produced and administered through edible plants |
CA2135201A1 (fr) * | 1992-05-08 | 1993-11-25 | Timothy J. Miller | Vaccin universel contre le coronavirus |
EP0640098B1 (fr) * | 1992-05-08 | 2002-10-09 | Pfizer Inc. | Gene s du coronavirus canin et ses applications |
AU721367B2 (en) * | 1993-02-26 | 2000-06-29 | Wyeth Holdings Corporation | Canine coronavirus vaccine from feline enteric coronavirus |
EP0612532A3 (fr) * | 1993-02-26 | 1998-02-04 | Solvay Animal Health, Inc. | Vaccin contre le coronavirus canin à partir de coronavirus entérique félin |
GB2316681B (en) * | 1993-09-16 | 1998-04-15 | Dimminaco Ag Sa Ltd | Antigenically active proteins/polypeptides and coronavirus vaccines containing the same |
FR2724385B1 (fr) * | 1994-08-29 | 1996-12-13 | Rhone Merieux | Vaccin de la peritonite infectieuse feline. |
WO1997010347A1 (fr) * | 1995-09-15 | 1997-03-20 | Howard John A | Cassettes d'expression et procedes d'administration de vaccins veterinaires |
WO1998027433A1 (fr) * | 1996-12-18 | 1998-06-25 | Engene Biotechnologies, Inc | Diagnostic specifique des anticorps contre le virus de la peritonite infectieuse feline |
AU1408499A (en) * | 1997-11-14 | 1999-06-07 | Thomas P. Brown | Compositions and methods to prevent turkey enteritis |
WO2001009290A2 (fr) * | 1999-07-30 | 2001-02-08 | Laboratorio Avi-Mex, S.A. De C.V. | Serotype du virus de bronchite infectieuse aviaire |
FR2828405B1 (fr) * | 2001-08-09 | 2005-06-24 | Virbac Sa | Vaccin anti-coronavirus |
WO2005010034A1 (fr) * | 2003-07-21 | 2005-02-03 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | Fragments solubles de la glycoproteine de spicule sras-cov |
US7605135B2 (en) * | 2003-11-10 | 2009-10-20 | The University Of Hong Kong | Baicalin as a treatment for SARS infection |
ITMI20111182A1 (it) * | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
WO2015143335A1 (fr) * | 2014-03-20 | 2015-09-24 | The University Of North Carolina At Chapel Hill | Méthodes et compositions pour protéines spike de coronavirus chimère |
CN113248576A (zh) * | 2020-02-12 | 2021-08-13 | 北京科兴中维生物技术有限公司 | 一种针对冠状病毒的核酸疫苗及其制备方法 |
WO2022020815A1 (fr) * | 2020-07-24 | 2022-01-27 | Soligenix, Inc. | Compositions d'anticorps/d'adjuvants et méthodes de génération de réponse immunitaire contre les coronavirus |
CN113072626B (zh) * | 2021-04-25 | 2023-05-05 | 龙岩学院 | 一种猫冠状病毒s重组蛋白及其制备方法 |
CN113238048B (zh) * | 2021-05-11 | 2024-03-15 | 抗码(苏州)生物科技有限公司 | 一种诊断标志物及其在区分新冠病毒感染和新冠病毒灭活疫苗接种中的应用 |
CN114057894B (zh) * | 2021-06-18 | 2022-08-05 | 国药中生生物技术研究院有限公司 | 一种产生广谱交叉中和活性的重组新型冠状病毒rbd三聚体蛋白疫苗、其制备方法和应用 |
CN114478716B (zh) * | 2021-12-28 | 2024-05-28 | 梅州市人民医院(梅州市医学科学院) | 一种多肽组合及其在新型冠状病毒抗体检测中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63123385A (ja) * | 1986-09-05 | 1988-05-27 | デュファル・インテルナチオナル・レセールフ・ベー・ヴェー | 新規抗原的活性蛋白質およびぺプチド、並びにネコ科感染性腹膜炎ウイルスワクチン |
CA2005291C (fr) * | 1988-12-30 | 1999-01-26 | Beverly Dale | Instruments de diagnostic du virus de la peritonite infectieuse des felins |
EP0489033B1 (fr) * | 1989-08-22 | 1994-10-19 | Veterinary Infectious Disease Organization | Polypeptides de coronavirus bovins et vaccins contre ce virus |
NZ240558A (en) * | 1990-11-14 | 1994-11-25 | Smithkline Beecham Corp | Recombinant feline coronavirus s proteins useful in diagnosis and vaccination against feline peritonitis virus disease |
CA2135201A1 (fr) * | 1992-05-08 | 1993-11-25 | Timothy J. Miller | Vaccin universel contre le coronavirus |
EP0640098B1 (fr) * | 1992-05-08 | 2002-10-09 | Pfizer Inc. | Gene s du coronavirus canin et ses applications |
-
1993
- 1993-05-07 CA CA002135201A patent/CA2135201A1/fr not_active Abandoned
- 1993-05-07 AU AU42410/93A patent/AU678971B2/en not_active Ceased
- 1993-05-07 WO PCT/US1993/004365 patent/WO1993023421A1/fr not_active Application Discontinuation
- 1993-05-07 EP EP93911170A patent/EP0640096A4/fr not_active Withdrawn
- 1993-05-07 WO PCT/US1993/004384 patent/WO1993023422A1/fr not_active Application Discontinuation
- 1993-05-07 EP EP93911185A patent/EP0640097A4/fr not_active Withdrawn
- 1993-05-07 AU AU42404/93A patent/AU678970B2/en not_active Ceased
- 1993-05-07 CA CA002134898A patent/CA2134898A1/fr not_active Abandoned
- 1993-05-07 JP JP6503668A patent/JPH08501931A/ja active Pending
- 1993-05-07 JP JP6503657A patent/JPH07508176A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH08501931A (ja) | 1996-03-05 |
CA2135201A1 (fr) | 1993-11-25 |
EP0640097A1 (fr) | 1995-03-01 |
WO1993023422A1 (fr) | 1993-11-25 |
AU4240493A (en) | 1993-12-13 |
AU4241093A (en) | 1993-12-13 |
WO1993023421A1 (fr) | 1993-11-25 |
AU678970B2 (en) | 1997-06-19 |
EP0640096A1 (fr) | 1995-03-01 |
JPH07508176A (ja) | 1995-09-14 |
AU678971B2 (en) | 1997-06-19 |
EP0640097A4 (fr) | 1997-01-15 |
EP0640096A4 (fr) | 1997-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |