CA2135201A1 - Vaccin universel contre le coronavirus - Google Patents
Vaccin universel contre le coronavirusInfo
- Publication number
- CA2135201A1 CA2135201A1 CA002135201A CA2135201A CA2135201A1 CA 2135201 A1 CA2135201 A1 CA 2135201A1 CA 002135201 A CA002135201 A CA 002135201A CA 2135201 A CA2135201 A CA 2135201A CA 2135201 A1 CA2135201 A1 CA 2135201A1
- Authority
- CA
- Canada
- Prior art keywords
- ala
- leu
- gln
- ser
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229960005486 vaccine Drugs 0.000 title claims abstract description 37
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 83
- 229920001184 polypeptide Polymers 0.000 claims abstract description 75
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- MJOUSKQHAIARKI-JYJNAYRXSA-N Val-Phe-Val Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(O)=O)CC1=CC=CC=C1 MJOUSKQHAIARKI-JYJNAYRXSA-N 0.000 description 1
- MIKHIIQMRFYVOR-RCWTZXSCSA-N Val-Pro-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N)O MIKHIIQMRFYVOR-RCWTZXSCSA-N 0.000 description 1
- DEGUERSKQBRZMZ-FXQIFTODSA-N Val-Ser-Ala Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O DEGUERSKQBRZMZ-FXQIFTODSA-N 0.000 description 1
- CEKSLIVSNNGOKH-KZVJFYERSA-N Val-Thr-Ala Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C(C)C)N)O CEKSLIVSNNGOKH-KZVJFYERSA-N 0.000 description 1
- AOILQMZPNLUXCM-AVGNSLFASA-N Val-Val-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CCCCN AOILQMZPNLUXCM-AVGNSLFASA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940024548 aluminum oxide Drugs 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 244000309457 enveloped RNA virus Species 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 208000005098 feline infectious peritonitis Diseases 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 108010092114 histidylphenylalanine Proteins 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 108010003700 lysyl aspartic acid Proteins 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 108010068488 methionylphenylalanine Proteins 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012770 revaccination Methods 0.000 description 1
- 108010048818 seryl-histidine Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000005100 tissue tropism Effects 0.000 description 1
- 108010084932 tryptophyl-proline Proteins 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229940124856 vaccine component Drugs 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
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- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88217192A | 1992-05-08 | 1992-05-08 | |
| US07/882,171 | 1992-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2135201A1 true CA2135201A1 (fr) | 1993-11-25 |
Family
ID=25380027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002134898A Abandoned CA2134898A1 (fr) | 1992-05-08 | 1993-05-07 | Compositions et methodes de vaccination contre les coronavirus |
| CA002135201A Abandoned CA2135201A1 (fr) | 1992-05-08 | 1993-05-07 | Vaccin universel contre le coronavirus |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002134898A Abandoned CA2134898A1 (fr) | 1992-05-08 | 1993-05-07 | Compositions et methodes de vaccination contre les coronavirus |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP0640097A4 (fr) |
| JP (2) | JPH08501931A (fr) |
| AU (2) | AU678971B2 (fr) |
| CA (2) | CA2134898A1 (fr) |
| WO (2) | WO1993023422A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
| US5484719A (en) | 1991-08-26 | 1996-01-16 | Edible Vaccines, Inc. | Vaccines produced and administered through edible plants |
| EP0640097A4 (fr) * | 1992-05-08 | 1997-01-15 | Smithkline Beecham Corp | Compositions et procedes de vaccination contre les coronavirus. |
| ATE225805T1 (de) * | 1992-05-08 | 2002-10-15 | Pfizer | Hundecoronavirus s gen und verwendung davon |
| EP0612532A3 (fr) * | 1993-02-26 | 1998-02-04 | Solvay Animal Health, Inc. | Vaccin contre le coronavirus canin à partir de coronavirus entérique félin |
| AU721367B2 (en) * | 1993-02-26 | 2000-06-29 | Wyeth Holdings Corporation | Canine coronavirus vaccine from feline enteric coronavirus |
| GB2316681B (en) * | 1993-09-16 | 1998-04-15 | Dimminaco Ag Sa Ltd | Antigenically active proteins/polypeptides and coronavirus vaccines containing the same |
| FR2724385B1 (fr) * | 1994-08-29 | 1996-12-13 | Rhone Merieux | Vaccin de la peritonite infectieuse feline. |
| CA2232023A1 (fr) * | 1995-09-15 | 1997-03-20 | John A. Howard | Cassettes d'expression et procedes d'administration de vaccins veterinaires |
| WO1998027433A1 (fr) * | 1996-12-18 | 1998-06-25 | Engene Biotechnologies, Inc | Diagnostic specifique des anticorps contre le virus de la peritonite infectieuse feline |
| WO1999025838A1 (fr) * | 1997-11-14 | 1999-05-27 | University Of Georgia Research Foundation, Inc. | Compositions et procedes destines a prevenir l'enterite de la dinde |
| WO2001009290A2 (fr) * | 1999-07-30 | 2001-02-08 | Laboratorio Avi-Mex, S.A. De C.V. | Serotype du virus de bronchite infectieuse aviaire |
| FR2828405B1 (fr) * | 2001-08-09 | 2005-06-24 | Virbac Sa | Vaccin anti-coronavirus |
| EP1648927A1 (fr) * | 2003-07-21 | 2006-04-26 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Fragments solubles de la glycoproteine de spicule sras-cov |
| US7605135B2 (en) * | 2003-11-10 | 2009-10-20 | The University Of Hong Kong | Baicalin as a treatment for SARS infection |
| ITMI20111182A1 (it) * | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
| WO2015143335A1 (fr) * | 2014-03-20 | 2015-09-24 | The University Of North Carolina At Chapel Hill | Méthodes et compositions pour protéines spike de coronavirus chimère |
| CN113248576A (zh) * | 2020-02-12 | 2021-08-13 | 北京科兴中维生物技术有限公司 | 一种针对冠状病毒的核酸疫苗及其制备方法 |
| WO2022020815A1 (fr) * | 2020-07-24 | 2022-01-27 | Soligenix, Inc. | Compositions d'anticorps/d'adjuvants et méthodes de génération de réponse immunitaire contre les coronavirus |
| CN113072626B (zh) * | 2021-04-25 | 2023-05-05 | 龙岩学院 | 一种猫冠状病毒s重组蛋白及其制备方法 |
| CN113238048B (zh) * | 2021-05-11 | 2024-03-15 | 抗码(苏州)生物科技有限公司 | 一种诊断标志物及其在区分新冠病毒感染和新冠病毒灭活疫苗接种中的应用 |
| CN113292640B (zh) * | 2021-06-18 | 2021-12-24 | 国药中生生物技术研究院有限公司 | 一种产生广谱交叉中和活性的重组新型冠状病毒rbd三聚体蛋白疫苗、其制备方法和应用 |
| CN114478716A (zh) * | 2021-12-28 | 2022-05-13 | 梅州市人民医院(梅州市医学科学院) | 一种多肽组合及其在新型冠状病毒抗体检测中的应用 |
| CN114773487A (zh) * | 2022-05-31 | 2022-07-22 | 湖南大学 | 一种流感病毒和新型冠状病毒融合重组蛋白疫苗免疫原及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0264979A1 (fr) * | 1986-09-05 | 1988-04-27 | Duphar International Research B.V | Protéines et peptides ayant une activité antigénique et vaccins contre le virus de la péritonite infectieuse des félins (FIPV) |
| CA2005291C (fr) * | 1988-12-30 | 1999-01-26 | Beverly Dale | Instruments de diagnostic du virus de la peritonite infectieuse des felins |
| EP0489033B1 (fr) * | 1989-08-22 | 1994-10-19 | Veterinary Infectious Disease Organization | Polypeptides de coronavirus bovins et vaccins contre ce virus |
| NZ240558A (en) * | 1990-11-14 | 1994-11-25 | Smithkline Beecham Corp | Recombinant feline coronavirus s proteins useful in diagnosis and vaccination against feline peritonitis virus disease |
| EP0640097A4 (fr) * | 1992-05-08 | 1997-01-15 | Smithkline Beecham Corp | Compositions et procedes de vaccination contre les coronavirus. |
| ATE225805T1 (de) * | 1992-05-08 | 2002-10-15 | Pfizer | Hundecoronavirus s gen und verwendung davon |
-
1993
- 1993-05-07 EP EP93911185A patent/EP0640097A4/fr not_active Withdrawn
- 1993-05-07 JP JP6503668A patent/JPH08501931A/ja active Pending
- 1993-05-07 WO PCT/US1993/004384 patent/WO1993023422A1/fr not_active Application Discontinuation
- 1993-05-07 AU AU42410/93A patent/AU678971B2/en not_active Ceased
- 1993-05-07 CA CA002134898A patent/CA2134898A1/fr not_active Abandoned
- 1993-05-07 WO PCT/US1993/004365 patent/WO1993023421A1/fr not_active Application Discontinuation
- 1993-05-07 AU AU42404/93A patent/AU678970B2/en not_active Ceased
- 1993-05-07 JP JP6503657A patent/JPH07508176A/ja active Pending
- 1993-05-07 CA CA002135201A patent/CA2135201A1/fr not_active Abandoned
- 1993-05-07 EP EP93911170A patent/EP0640096A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU678970B2 (en) | 1997-06-19 |
| EP0640096A4 (fr) | 1997-01-15 |
| WO1993023421A1 (fr) | 1993-11-25 |
| EP0640096A1 (fr) | 1995-03-01 |
| AU4240493A (en) | 1993-12-13 |
| WO1993023422A1 (fr) | 1993-11-25 |
| AU678971B2 (en) | 1997-06-19 |
| JPH08501931A (ja) | 1996-03-05 |
| AU4241093A (en) | 1993-12-13 |
| EP0640097A4 (fr) | 1997-01-15 |
| CA2134898A1 (fr) | 1993-11-25 |
| EP0640097A1 (fr) | 1995-03-01 |
| JPH07508176A (ja) | 1995-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |