CA2118697A1 - Indole derivatives as 5-alpha-reductase inhibitor - Google Patents

Indole derivatives as 5-alpha-reductase inhibitor

Info

Publication number
CA2118697A1
CA2118697A1 CA002118697A CA2118697A CA2118697A1 CA 2118697 A1 CA2118697 A1 CA 2118697A1 CA 002118697 A CA002118697 A CA 002118697A CA 2118697 A CA2118697 A CA 2118697A CA 2118697 A1 CA2118697 A1 CA 2118697A1
Authority
CA
Canada
Prior art keywords
compound
salt
alkyl
nmr
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002118697A
Other languages
English (en)
French (fr)
Inventor
Satoshi Okada
Kozo Sawada
Natsuko Kayakiri
Yuki Saitoh
Hirokazu Tanaka
Masashi Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/757,522 external-priority patent/US5212320A/en
Application filed by Individual filed Critical Individual
Publication of CA2118697A1 publication Critical patent/CA2118697A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CA002118697A 1991-09-11 1992-09-09 Indole derivatives as 5-alpha-reductase inhibitor Abandoned CA2118697A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/757,522 1991-09-11
US07/757,522 US5212320A (en) 1990-05-21 1991-09-11 Indole derivatives and their use for testosterone 5-alpha-reductase-mediated diseases
US79259591A 1991-11-15 1991-11-15
US07/792,595 1991-11-15

Publications (1)

Publication Number Publication Date
CA2118697A1 true CA2118697A1 (en) 1993-03-18

Family

ID=27116395

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002118697A Abandoned CA2118697A1 (en) 1991-09-11 1992-09-09 Indole derivatives as 5-alpha-reductase inhibitor

Country Status (4)

Country Link
EP (1) EP0603278A1 (ja)
JP (1) JPH07501790A (ja)
CA (1) CA2118697A1 (ja)
WO (1) WO1993005019A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9302577D0 (en) * 1993-02-10 1993-03-24 Fujisawa Pharmaceutical Co Indole derivatives
GB9310092D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co Indole derivatives
AU681021B2 (en) * 1994-03-30 1997-08-14 Zeria Pharmaceutical Co., Ltd. Indole derivative and medicine containing the same
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
KR100368297B1 (ko) * 2000-05-31 2003-01-24 이승기 양성 전립선 비대증 치료용 메나퀴논 7

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1492929A (fr) * 1966-05-11 1967-08-25 Roussel Uclaf Nouveaux 1-(omega-carboxyalcoyl) indoles substitués et procédé de préparation
FR7337M (ja) * 1968-01-11 1969-10-13
US3557142A (en) * 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
AU574383B2 (en) * 1983-09-28 1988-07-07 Nippon Zoki Pharmaceutical Co., Ltd. Acylindole derivatives
GB9011335D0 (en) * 1990-05-21 1990-07-11 Fujisawa Pharmaceutical Co Indolebutyric acid derivatives and process for preparation thereof

Also Published As

Publication number Publication date
EP0603278A1 (en) 1994-06-29
JPH07501790A (ja) 1995-02-23
WO1993005019A1 (en) 1993-03-18

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Legal Events

Date Code Title Description
FZDE Dead