CA2104879A1 - Use of cucurbitin for the preparation of a cosmetic or pharmaceutical, particularly dermatological, antiallergenic composition and method involving application thereof - Google Patents
Use of cucurbitin for the preparation of a cosmetic or pharmaceutical, particularly dermatological, antiallergenic composition and method involving application thereofInfo
- Publication number
- CA2104879A1 CA2104879A1 CA002104879A CA2104879A CA2104879A1 CA 2104879 A1 CA2104879 A1 CA 2104879A1 CA 002104879 A CA002104879 A CA 002104879A CA 2104879 A CA2104879 A CA 2104879A CA 2104879 A1 CA2104879 A1 CA 2104879A1
- Authority
- CA
- Canada
- Prior art keywords
- cucurbitine
- extract
- esters
- composition
- cucurbitaceae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- DWAKXSZUASEUHH-UHFFFAOYSA-N cucurbitine Natural products OC(=O)C1(N)CCNC1 DWAKXSZUASEUHH-UHFFFAOYSA-N 0.000 title claims abstract description 100
- DWAKXSZUASEUHH-RXMQYKEDSA-N Cucurbitine Chemical compound OC(=O)[C@@]1(N)CCNC1 DWAKXSZUASEUHH-RXMQYKEDSA-N 0.000 title claims abstract description 97
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 239000002537 cosmetic Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 28
- 239000000284 extract Substances 0.000 claims abstract description 29
- 241000219104 Cucurbitaceae Species 0.000 claims abstract description 18
- 230000003266 anti-allergic effect Effects 0.000 claims abstract description 11
- 230000002009 allergenic effect Effects 0.000 claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- 230000002829 reductive effect Effects 0.000 claims abstract description 7
- 150000002148 esters Chemical class 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 31
- 240000001980 Cucurbita pepo Species 0.000 claims description 20
- 208000010668 atopic eczema Diseases 0.000 claims description 20
- 235000009852 Cucurbita pepo Nutrition 0.000 claims description 19
- 239000000419 plant extract Substances 0.000 claims description 19
- 230000000172 allergic effect Effects 0.000 claims description 18
- 230000015572 biosynthetic process Effects 0.000 claims description 17
- 230000008569 process Effects 0.000 claims description 15
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 238000003786 synthesis reaction Methods 0.000 claims description 12
- 239000002502 liposome Substances 0.000 claims description 11
- 230000007062 hydrolysis Effects 0.000 claims description 8
- 238000006460 hydrolysis reaction Methods 0.000 claims description 8
- 235000019270 ammonium chloride Nutrition 0.000 claims description 7
- DHGMDHQNUNRMIN-UHFFFAOYSA-N 1-benzylpyrrolidin-3-one Chemical compound C1C(=O)CCN1CC1=CC=CC=C1 DHGMDHQNUNRMIN-UHFFFAOYSA-N 0.000 claims description 6
- 240000004244 Cucurbita moschata Species 0.000 claims description 6
- 235000009854 Cucurbita moschata Nutrition 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
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- 230000003197 catalytic effect Effects 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000004494 ethyl ester group Chemical group 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 150000002632 lipids Chemical class 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- IRGJVQIJENCTQF-UHFFFAOYSA-N tritoqualine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=C(OCC)C(OCC)=C(OCC)C(N)=C2C(=O)O1 IRGJVQIJENCTQF-UHFFFAOYSA-N 0.000 description 8
- 229960002634 tritoqualine Drugs 0.000 description 8
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 6
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- 239000000377 silicon dioxide Substances 0.000 description 6
- COESXKHUIKDTRP-UHFFFAOYSA-N 3-amino-1-benzylpyrrolidine-3-carbonitrile Chemical compound C1C(N)(C#N)CCN1CC1=CC=CC=C1 COESXKHUIKDTRP-UHFFFAOYSA-N 0.000 description 5
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 5
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 150000001412 amines Chemical group 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 244000309464 bull Species 0.000 description 3
- 239000003610 charcoal Substances 0.000 description 3
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- 238000004587 chromatography analysis Methods 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 3
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
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- 241000605411 Lloydia Species 0.000 description 2
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- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000004094 preconcentration Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- DATJETPTDKFEEF-UHFFFAOYSA-N pyrrolidine-3-carbonitrile Chemical compound N#CC1CCNC1 DATJETPTDKFEEF-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR91/02420 | 1991-02-28 | ||
| FR9102420A FR2673375A1 (fr) | 1991-02-28 | 1991-02-28 | Utilisation de la cucurbitine pour la preparation d'une composition cosmetique ou pharmaceutique, notamment dermatologique, anti-allergique, et procede en comportant application. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2104879A1 true CA2104879A1 (en) | 1992-08-29 |
Family
ID=9410208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002104879A Abandoned CA2104879A1 (en) | 1991-02-28 | 1992-02-24 | Use of cucurbitin for the preparation of a cosmetic or pharmaceutical, particularly dermatological, antiallergenic composition and method involving application thereof |
Country Status (9)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4241487C2 (de) * | 1992-12-09 | 1996-07-25 | Indena Spa | Neue Extrakte von Cucurbita sp., Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln und in der Kosmetik |
| ES2070788B1 (es) * | 1993-12-09 | 1996-01-01 | Indena Spa | Nuevos extractos de cucurbita sp. proceso para su preparacion y su uso en medicamentos y cosmeticos. |
| JP2002138028A (ja) * | 2000-10-30 | 2002-05-14 | Pias Arise Kk | 皮膚外用剤とその製造方法 |
| JP2003171225A (ja) * | 2001-11-30 | 2003-06-17 | Fancl Corp | インテグリンα６β４産生促進用組成物 |
| FR2849776B1 (fr) * | 2003-01-10 | 2007-04-20 | Vincience | Utilisation d'un extrait aqueux de pepins d'un vegetal du genre cucurbita comme principe actif dans une composition cosmetique et/ou pharmaceutique |
| JP4630102B2 (ja) * | 2005-03-30 | 2011-02-09 | 株式会社ナリス化粧品 | ヒアルロン酸産生促進剤、及びこれを含有する化粧料 |
| CN101528191A (zh) * | 2006-10-19 | 2009-09-09 | 荷兰联合利华有限公司 | 头发处理组合物 |
| JP4947034B2 (ja) * | 2008-10-30 | 2012-06-06 | Ｊｎｃ株式会社 | ポリリジン製剤およびこれを含有する化粧料組成物 |
| CN102453033B (zh) * | 2010-10-29 | 2014-11-26 | 上海医药工业研究院 | 一种乙内酰脲衍生物的制备方法 |
| CN112898189B (zh) * | 2021-02-23 | 2024-01-26 | 西安天一生物技术股份有限公司 | 超临界南瓜籽蛋白处理废液制备南瓜子氨酸的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5251033A (en) * | 1975-10-16 | 1977-04-23 | Koichi Ogawa | Cosmetics |
| FR2522500A1 (fr) * | 1982-03-02 | 1983-09-09 | Rougereau Andre | Medicament et cosmetique a base de potiron |
| JPH062654B2 (ja) * | 1985-06-17 | 1994-01-12 | 株式会社資生堂 | 頭髪化粧料 |
| JPS6253911A (ja) * | 1985-09-02 | 1987-03-09 | Shiseido Co Ltd | 化粧料 |
| JPS6287241A (ja) * | 1985-10-11 | 1987-04-21 | Lion Corp | 水中油滴型乳化組成物 |
| JPS62234013A (ja) * | 1986-04-02 | 1987-10-14 | Osaka Yakuhin Kenkyusho:Kk | 浴用剤 |
-
1991
- 1991-02-28 FR FR9102420A patent/FR2673375A1/fr active Granted
-
1992
- 1992-02-24 JP JP50653992A patent/JP3248908B2/ja not_active Expired - Lifetime
- 1992-02-24 AT AT92907164T patent/ATE157354T1/de not_active IP Right Cessation
- 1992-02-24 CA CA002104879A patent/CA2104879A1/en not_active Abandoned
- 1992-02-24 EP EP92907164A patent/EP0575454B1/fr not_active Expired - Lifetime
- 1992-02-24 WO PCT/FR1992/000164 patent/WO1992015563A1/fr active Application Filing
- 1992-02-24 KR KR1019930702580A patent/KR100244051B1/ko not_active Expired - Fee Related
- 1992-02-24 DE DE69221855T patent/DE69221855T2/de not_active Expired - Fee Related
- 1992-02-27 CN CN92101145A patent/CN1056511C/zh not_active Expired - Fee Related
-
2001
- 2001-05-10 JP JP2001140646A patent/JP3366324B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2673375B1 (enrdf_load_stackoverflow) | 1995-03-10 |
| JP3248908B2 (ja) | 2002-01-21 |
| CN1056511C (zh) | 2000-09-20 |
| EP0575454A1 (fr) | 1993-12-29 |
| KR930703252A (ko) | 1993-11-29 |
| JP2001316263A (ja) | 2001-11-13 |
| JP3366324B2 (ja) | 2003-01-14 |
| DE69221855T2 (de) | 1998-03-26 |
| KR100244051B1 (ko) | 2000-03-02 |
| CN1065009A (zh) | 1992-10-07 |
| DE69221855D1 (de) | 1997-10-02 |
| ATE157354T1 (de) | 1997-09-15 |
| EP0575454B1 (fr) | 1997-08-27 |
| WO1992015563A1 (fr) | 1992-09-17 |
| JPH06507390A (ja) | 1994-08-25 |
| FR2673375A1 (fr) | 1992-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |