CA2098446A1 - 2,5-dihydro-2,5-dioxo-1h-azepines et 2,5-dihydro-2-oxo-1h-azepines et leur utilisation comme antagonistes des recepteurs de l'acide amine excitateur et de la glycine - Google Patents

2,5-dihydro-2,5-dioxo-1h-azepines et 2,5-dihydro-2-oxo-1h-azepines et leur utilisation comme antagonistes des recepteurs de l'acide amine excitateur et de la glycine

Info

Publication number
CA2098446A1
CA2098446A1 CA 2098446 CA2098446A CA2098446A1 CA 2098446 A1 CA2098446 A1 CA 2098446A1 CA 2098446 CA2098446 CA 2098446 CA 2098446 A CA2098446 A CA 2098446A CA 2098446 A1 CA2098446 A1 CA 2098446A1
Authority
CA
Canada
Prior art keywords
hydroxy
dihydro
benzazepine
dioxo
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2098446
Other languages
English (en)
Inventor
Eckard Weber
John F. W. Keana
Kenton J. Swartz
Walter J. Koroshetz
Alun H. Rees
James E. Huettner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2098446A1 publication Critical patent/CA2098446A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA 2098446 1992-09-30 1993-06-15 2,5-dihydro-2,5-dioxo-1h-azepines et 2,5-dihydro-2-oxo-1h-azepines et leur utilisation comme antagonistes des recepteurs de l'acide amine excitateur et de la glycine Abandoned CA2098446A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95368992A 1992-09-30 1992-09-30
US07/953,689 1992-09-30
US4249493A 1993-04-02 1993-04-02
US08/042,494 1993-04-02

Publications (1)

Publication Number Publication Date
CA2098446A1 true CA2098446A1 (fr) 1994-03-31

Family

ID=26719306

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2098446 Abandoned CA2098446A1 (fr) 1992-09-30 1993-06-15 2,5-dihydro-2,5-dioxo-1h-azepines et 2,5-dihydro-2-oxo-1h-azepines et leur utilisation comme antagonistes des recepteurs de l'acide amine excitateur et de la glycine

Country Status (3)

Country Link
AU (1) AU5349894A (fr)
CA (1) CA2098446A1 (fr)
WO (1) WO1994007500A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2313714T3 (es) * 1992-06-22 2009-03-01 The Regents Of The University Of California Antagonistas de receptores de glicina y uso de los mismos.
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
US5476933A (en) * 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives

Also Published As

Publication number Publication date
AU5349894A (en) 1994-04-26
WO1994007500A1 (fr) 1994-04-14

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Legal Events

Date Code Title Description
FZDE Dead