CA2097185C - Vecteurs recombinants viraux pour l'expression dans des cellules musculaires - Google Patents
Vecteurs recombinants viraux pour l'expression dans des cellules musculaires Download PDFInfo
- Publication number
- CA2097185C CA2097185C CA002097185A CA2097185A CA2097185C CA 2097185 C CA2097185 C CA 2097185C CA 002097185 A CA002097185 A CA 002097185A CA 2097185 A CA2097185 A CA 2097185A CA 2097185 C CA2097185 C CA 2097185C
- Authority
- CA
- Canada
- Prior art keywords
- muscle cells
- vector
- adenovirus
- nucleotide sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000663 muscle cell Anatomy 0.000 title claims abstract description 73
- 239000013598 vector Substances 0.000 title claims abstract description 72
- 230000003612 virological effect Effects 0.000 title abstract description 6
- 239000002773 nucleotide Substances 0.000 claims abstract description 51
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 51
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 36
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 36
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 28
- 229920001184 polypeptide Polymers 0.000 claims abstract description 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 27
- 230000007170 pathology Effects 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 14
- 238000003780 insertion Methods 0.000 claims abstract description 14
- 230000037431 insertion Effects 0.000 claims abstract description 14
- 241000701161 unidentified adenovirus Species 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 37
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- 210000003205 muscle Anatomy 0.000 claims description 23
- 230000002950 deficient Effects 0.000 claims description 21
- 241001465754 Metazoa Species 0.000 claims description 18
- 238000001361 intraarterial administration Methods 0.000 claims description 17
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- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 claims description 14
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- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 4
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- 241000714474 Rous sarcoma virus Species 0.000 description 8
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- 241000700605 Viruses Species 0.000 description 7
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- 239000002243 precursor Substances 0.000 description 3
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- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 241000598171 Human adenovirus sp. Species 0.000 description 1
- 101150102264 IE gene Proteins 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9111947A FR2681786A1 (fr) | 1991-09-27 | 1991-09-27 | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
| FR91/11947 | 1991-09-27 | ||
| PCT/FR1992/000898 WO1993006223A1 (fr) | 1991-09-27 | 1992-09-25 | Vecteurs recombinants viraux pour l'expression dans des cellules musculaires |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2097185A1 CA2097185A1 (fr) | 1993-03-28 |
| CA2097185C true CA2097185C (fr) | 2007-07-24 |
Family
ID=9417378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002097185A Expired - Lifetime CA2097185C (fr) | 1991-09-27 | 1992-09-25 | Vecteurs recombinants viraux pour l'expression dans des cellules musculaires |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0559884B2 (oth) |
| JP (1) | JP3487597B2 (oth) |
| AT (1) | ATE192500T1 (oth) |
| AU (1) | AU666142B2 (oth) |
| CA (1) | CA2097185C (oth) |
| DE (1) | DE69230993T3 (oth) |
| DK (1) | DK0559884T4 (oth) |
| ES (1) | ES2147553T5 (oth) |
| FR (1) | FR2681786A1 (oth) |
| GR (1) | GR3034094T3 (oth) |
| SG (1) | SG49081A1 (oth) |
| WO (1) | WO1993006223A1 (oth) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538722A (en) * | 1989-06-13 | 1996-07-23 | Stanford University | Isolation, growth, differentiation and genetic engineering of human muscle cells |
| WO1994010322A1 (en) * | 1992-10-29 | 1994-05-11 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
| EP0957172B1 (en) | 1992-11-18 | 2005-10-19 | Arch Development Corporation | Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle |
| FR2705361B1 (fr) * | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| US6133028A (en) * | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US20020136708A1 (en) | 1993-06-24 | 2002-09-26 | Graham Frank L. | System for production of helper dependent adenovirus vectors based on use of endonucleases |
| US6730507B1 (en) | 1993-06-24 | 2004-05-04 | Merck & Co., Inc. | Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration |
| US6140087A (en) * | 1993-06-24 | 2000-10-31 | Advec, Inc. | Adenovirus vectors for gene therapy |
| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US7045347B2 (en) | 1993-06-24 | 2006-05-16 | Advec, Inc. | Helper dependent adenovirus vectors based on integrase family site-specific recombinases |
| US6080569A (en) | 1993-06-24 | 2000-06-27 | Merck & Co., Inc. | Adenovirus vectors generated from helper viruses and helper-dependent vectors |
| CA2166118C (en) * | 1993-06-24 | 2007-04-17 | Frank L. Graham | Adenovirus vectors for gene therapy |
| US6120764A (en) * | 1993-06-24 | 2000-09-19 | Advec, Inc. | Adenoviruses for control of gene expression |
| FR2718749B1 (fr) * | 1994-04-18 | 1996-05-31 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| NZ269156A (en) * | 1993-07-13 | 1996-03-26 | Rhone Poulenc Rorer Sa | Defective recombinant adenovirus vector incapable of replicating autonomously in a target cell and its use in gene therapy |
| FR2707664B1 (fr) * | 1993-07-13 | 1995-09-29 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| FR2712812B1 (fr) * | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| CA2188575A1 (en) * | 1995-02-28 | 1996-09-06 | H. Kirk Hammond | Gene transfer-mediated angiogenesis therapy |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| US6281010B1 (en) * | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
| US6974694B2 (en) | 1995-06-07 | 2005-12-13 | Advec, Inc. | Adenoviruses for control of gene expression |
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US5837534A (en) * | 1995-11-14 | 1998-11-17 | The Board Of Regents Of The University Of Texas System | Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells |
| US5866552A (en) * | 1996-09-06 | 1999-02-02 | The Trustees Of The University Of Pennsylvania | Method for expressing a gene in the absence of an immune response |
| US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
| CN1261807A (zh) | 1997-06-30 | 2000-08-02 | 罗纳-布朗克罗莱尔股份有限公司 | 向横纹肌中转移核酸的改进方法和用于实施该方法的组合 |
| US6914131B1 (en) | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| CA2308606A1 (en) | 1997-11-06 | 1999-05-20 | Chiron S.P.A. | Neisserial antigens |
| ATE446368T1 (de) | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| NZ505955A (en) | 1998-02-06 | 2005-04-29 | Collateral Therapeutics Inc | Variants of the angiogenic factor vascular endothelial cell growth factor: VEGF-A, and pharmaceutical use |
| EP2261345A3 (en) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| EP1121437B1 (en) | 1998-10-15 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Metastatic breast and colon cancer regulated genes |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| EP1961813B1 (en) | 1998-12-16 | 2011-08-10 | Novartis Vaccines and Diagnostics, Inc. | Human cyclin-dependent kinase (hPNQALRE) |
| US6673601B1 (en) | 1999-04-15 | 2004-01-06 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| EP1721982B1 (en) | 1999-04-15 | 2013-04-10 | Boehringer Ingelheim Vetmedica GmbH | Chimeric lyssavirus nucleic acids and polypeptides |
| RU2245366C2 (ru) | 1999-04-30 | 2005-01-27 | Чирон С.Р.Л. | Антиген neisseria, кодирующая его нуклеиновая кислота, их использование |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| PT2275552E (pt) | 1999-10-29 | 2015-12-07 | Glaxosmithkline Biolog Sa | Péptidos antigénicos de neisseria |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| EP1261723B1 (en) | 2000-02-28 | 2008-02-27 | Novartis Vaccines and Diagnostics S.r.l. | Hybrid expression of neisserial proteins |
| US7238672B1 (en) | 2000-04-17 | 2007-07-03 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| EP1950297A2 (en) | 2000-05-31 | 2008-07-30 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers |
| EP1191104A1 (en) * | 2000-09-26 | 2002-03-27 | Introgene B.V. | Gene delivery vehicles and use thereof in the preparation of a medicament and/or vaccine |
| DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
| KR20030042003A (ko) * | 2000-10-06 | 2003-05-27 | 가부시키가이샤 디나벡크 겐큐쇼 | 골격근에 외래유전자를 도입하기 위한 파라믹소바이러스 벡터 |
| MXPA03003690A (es) | 2000-10-27 | 2004-05-05 | Chiron Spa | Acidos nucleicos y proteinas de los grupos a y b de estreptococos. |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| FR2829136B1 (fr) | 2001-08-29 | 2006-11-17 | Aventis Pharma Sa | Derives lipidiques d'aminoglycosides |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| PT1497438E (pt) | 2002-04-25 | 2010-02-04 | Crucell Holland Bv | Meios e métodos para a produção de vectores de adenovírus |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| WO2005093064A1 (ja) | 2004-03-29 | 2005-10-06 | Galpharma Co., Ltd. | 新規ガレクチン９改変体タンパク質及びその用途 |
| EP1799243B1 (en) | 2004-10-06 | 2015-07-15 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| US8999944B2 (en) | 2005-01-20 | 2015-04-07 | University Of Rochester | Thioredoxin interacting protein (TXNIP) as regulator of vascular function |
| US8026354B2 (en) | 2005-11-23 | 2011-09-27 | Institut Pasteur | Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use |
| WO2008020335A2 (en) | 2006-06-09 | 2008-02-21 | Novartis Ag | Immunogenic compositions for streptococcus agalactiae |
| WO2008116116A2 (en) | 2007-03-20 | 2008-09-25 | Harold Brem | Gm-csf cosmeceutical compositions and methods of use thereof |
| EP2331071A1 (en) | 2008-09-05 | 2011-06-15 | Institut National De La Sante Et De La Recherche Medicale | Novel multimodular assembly useful for intracellular delivery |
| WO2010107991A2 (en) | 2009-03-18 | 2010-09-23 | Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Use of ixolaris, a tissue factor inhibitor, for the treatment and prevention of cancer |
| CN102596221B (zh) | 2009-06-10 | 2019-06-04 | 纽约大学 | 病理tau蛋白的免疫靶向 |
| EP2658567A4 (en) | 2010-12-28 | 2014-09-24 | Univ Rochester | METHOD FOR MODIFYING INSULIN SIGNAL TRANSMISSION BY BILIVERDINREDUCTASE (BVR) AND BVR-DERIVED PEPTIDES |
| HUE051021T2 (hu) | 2011-09-07 | 2021-01-28 | Sinai School Medicine | Ceramidáz és sejtek differenciálódása |
| WO2014063155A1 (en) | 2012-10-21 | 2014-04-24 | University Of Rochester | Thy1 (cd90) as a novel therapy to control adipose tissue accumulation |
| WO2014176259A1 (en) | 2013-04-22 | 2014-10-30 | Icahn School Of Medicine At Mount Sinai | Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis |
| WO2017079442A1 (en) | 2015-11-04 | 2017-05-11 | Icahn School Of Medicine At Mount Sinai | Methods of treating tumors and cancer, and identifying candidate subjects for such treatment |
| WO2017189730A1 (en) | 2016-04-26 | 2017-11-02 | Icahn School Of Medicine At Mount Sinai | Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76751A (en) * | 1984-11-01 | 1991-04-15 | American Home Prod | Method and oral vaccines against infectious organisms using live,recombinant adenovirus for the production of antibodies |
| FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
| CA1339346C (en) * | 1986-08-01 | 1997-08-26 | Ian Allister Ramshaw | Recombinant chimeric vaccine |
| EP0465529B1 (en) * | 1989-03-21 | 1998-04-29 | Vical, Inc. | Expression of exogenous polynucleotide sequences in a vertebrate |
| EP0467987A4 (en) * | 1989-05-01 | 1992-07-08 | The University Of Notre Dame Du Lac | Methods and materials for expression of human plasminogen in a eukaryotic cell system |
| GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
-
1991
- 1991-09-27 FR FR9111947A patent/FR2681786A1/fr active Granted
-
1992
- 1992-09-25 AU AU27902/92A patent/AU666142B2/en not_active Expired
- 1992-09-25 JP JP50585393A patent/JP3487597B2/ja not_active Expired - Lifetime
- 1992-09-25 CA CA002097185A patent/CA2097185C/fr not_active Expired - Lifetime
- 1992-09-25 DK DK92921684T patent/DK0559884T4/da active
- 1992-09-25 WO PCT/FR1992/000898 patent/WO1993006223A1/fr not_active Ceased
- 1992-09-25 EP EP92921684A patent/EP0559884B2/fr not_active Expired - Lifetime
- 1992-09-25 ES ES92921684T patent/ES2147553T5/es not_active Expired - Lifetime
- 1992-09-25 DE DE69230993T patent/DE69230993T3/de not_active Expired - Lifetime
- 1992-09-25 SG SG1996005855A patent/SG49081A1/en unknown
- 1992-09-25 AT AT92921684T patent/ATE192500T1/de active
-
2000
- 2000-08-02 GR GR20000401791T patent/GR3034094T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0559884T4 (da) | 2004-08-02 |
| EP0559884A1 (fr) | 1993-09-15 |
| ATE192500T1 (de) | 2000-05-15 |
| ES2147553T5 (es) | 2004-11-16 |
| EP0559884B2 (fr) | 2004-04-07 |
| DK0559884T3 (da) | 2000-10-02 |
| GR3034094T3 (en) | 2000-11-30 |
| DE69230993T3 (de) | 2004-12-16 |
| CA2097185A1 (fr) | 1993-03-28 |
| AU666142B2 (en) | 1996-02-01 |
| WO1993006223A1 (fr) | 1993-04-01 |
| SG49081A1 (en) | 1998-05-18 |
| DE69230993T2 (de) | 2000-11-30 |
| DE69230993D1 (de) | 2000-06-08 |
| FR2681786A1 (fr) | 1993-04-02 |
| JP3487597B2 (ja) | 2004-01-19 |
| EP0559884B1 (fr) | 2000-05-03 |
| ES2147553T3 (es) | 2000-09-16 |
| FR2681786B1 (oth) | 1995-05-12 |
| AU2790292A (en) | 1993-04-27 |
| JPH06502771A (ja) | 1994-03-31 |
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