CA2095219A1 - Substituted indolizino[1,2-b]quinolinones - Google Patents

Substituted indolizino[1,2-b]quinolinones

Info

Publication number
CA2095219A1
CA2095219A1 CA002095219A CA2095219A CA2095219A1 CA 2095219 A1 CA2095219 A1 CA 2095219A1 CA 002095219 A CA002095219 A CA 002095219A CA 2095219 A CA2095219 A CA 2095219A CA 2095219 A1 CA2095219 A1 CA 2095219A1
Authority
CA
Canada
Prior art keywords
compound
quinolin
lower alkyl
methyl
indolizino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002095219A
Other languages
English (en)
French (fr)
Inventor
Hameed S. Allaudeen
David A. Berges
Robert P. Hertzberg
Randall K. Johnson
William D. Kingsbury
Stephen R. Petteway, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2095219A1 publication Critical patent/CA2095219A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002095219A 1990-10-31 1991-10-30 Substituted indolizino[1,2-b]quinolinones Abandoned CA2095219A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60621690A 1990-10-31 1990-10-31
US07/606,216 1990-10-31
US78306391A 1991-10-25 1991-10-25
US07/783,063 1991-10-25

Publications (1)

Publication Number Publication Date
CA2095219A1 true CA2095219A1 (en) 1992-05-01

Family

ID=27085175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095219A Abandoned CA2095219A1 (en) 1990-10-31 1991-10-30 Substituted indolizino[1,2-b]quinolinones

Country Status (9)

Country Link
EP (1) EP0555347A4 (xx)
JP (1) JPH06502642A (xx)
KR (1) KR930702289A (xx)
AU (1) AU8940491A (xx)
CA (1) CA2095219A1 (xx)
IE (1) IE913790A1 (xx)
NZ (1) NZ240406A (xx)
PT (1) PT99412A (xx)
WO (1) WO1992007856A1 (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
CA2118324A1 (en) * 1992-04-17 1993-10-28 David A. Berges Substituted indolizino¬1,2-b|quinolinones
MX9403275A (es) * 1993-05-03 1995-01-31 Smithkline Beecham Corp Metilendioxi[3,'4':6,7]indolizino-[1,2-b]quinolinonas substituidas.
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US5708005A (en) * 1995-06-27 1998-01-13 Takeda Chemical Industries, Ltd. Quinolines, their production and use
US6143891A (en) * 1995-11-02 2000-11-07 Glaxo Wellcome Inc. Method for preparing camptothecin derivatives
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
JP3046258B2 (ja) * 1997-04-11 2000-05-29 株式会社ヤクルト本社 １−クロロカルボニル−４−ピペリジノピペリジンまたはその塩酸塩の製造方法
JP5082033B2 (ja) 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒのモジュレーター
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
WO2003074524A2 (en) * 2002-03-01 2003-09-12 University Of Pittsburgh Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
US7064202B1 (en) * 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
WO2006019955A2 (en) 2004-07-14 2006-02-23 President And Fellows Of Harvard College Antiviral methods and compositions
WO2012176145A1 (en) * 2011-06-22 2012-12-27 Council Of Scientific & Industrial Research Insecticidal compositions isolated from nothapodites foetida and process for the extraction thereof
KR101721029B1 (ko) 2014-10-16 2017-03-29 연세대학교 산학협력단 인돌리지노[3,2-c]퀴놀린 유도체, 이의 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 낭포성 섬유증 예방 또는 치료용 약학조성물
WO2017014601A1 (ko) * 2015-07-23 2017-01-26 서울대학교 산학협력단 인돌리지노[3,2-ｃ]퀴놀린계 형광 프로브
KR101850607B1 (ko) 2015-07-23 2018-04-19 서울대학교산학협력단 인돌리지노[3,2-ｃ]퀴놀린계 형광 프로브

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (ja) * 1975-02-07 1983-06-24 日本ケミフア （株） ７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法

Also Published As

Publication number Publication date
AU8940491A (en) 1992-05-26
JPH06502642A (ja) 1994-03-24
WO1992007856A1 (en) 1992-05-14
NZ240406A (en) 1994-05-26
KR930702289A (ko) 1993-09-08
PT99412A (pt) 1992-10-30
EP0555347A1 (en) 1993-08-18
IE913790A1 (en) 1992-05-22
EP0555347A4 (en) 1995-01-11

Similar Documents

Publication Publication Date Title
CA2095219A1 (en) Substituted indolizino[1,2-b]quinolinones
FI91872B (fi) Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi
JP4138022B2 (ja) テトラヒドロピリド化合物
KR20030015221A (ko) 알킬화된 이미다조피리딘 유도체
PL119520B1 (en) Process for preparing novel,condensed pyrimidine derivatives pirimidina
AU2003241161B2 (en) Esters in position 20 of camptothecins
CS197276B2 (en) Method of producing new 1,5,10,10a-tetrahydrothiazolo/3,4-b/isoquinolines
Jaszfold-Howorko et al. Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5, 6-dimethyl)-6H-pyrido [4, 3-b] carbazole-1-N-[(dialkylamino) alkyl] carboxamides, a new promising series of antitumor olivacine derivatives
WO1993016698A1 (en) SUBSTITUTED FURO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLINONES
DE69119323T2 (de) Fluoräthylcamptothecinderivate
US4362739A (en) Pyrrolo(2,3-d)carbazole derivatives, compositions and use
US5883255A (en) Substituted indolizino 1,2-b!quinolinones
JP3364473B2 (ja) ７−オキソ−２，３，７，１４−テトラヒドロ−１Ｈ−ベンゾ〔ｂ〕ピラノ〔３，２−ｈ〕アクリジンカルボキシラートの新しい化合物、これらの製造方法及びこれらを含む医薬組成物
WO1993020818A1 (en) SUBSTITUTED INDOLIZINO[1,2-b]QUINOLINONES
JP2003055381A (ja) 新規なベンゾ〔ｂ〕ピラノ〔３，２−ｈ〕アクリジン−７−オン化合物、それらの製造方法、およびそれらを含有する医薬組成物
AU684777B2 (en) Substituted methylenedioxy(3',4':6,7)indolizino-(1,2-b)quinolinones
JPH024740A (ja) 三環式アミン誘導体
EP0637960A1 (en) SUBSTITUTED INDOLIZINO 1,2-b]QUINOLINONES
WO1995003803A1 (en) SUBSTITUTED FURO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLINONES
EP0276833A2 (en) Dipyrazoles useful as bronchodilators
GB1572920A (en) Quinoline carboxalic acid esters
JPH07101956A (ja) ヒドロキシカンプトテシン化合物の製法
EP0639183A1 (en) Nitrogen oxides of aza- and diaza-anthracenedione derivatives, their preparation and their use as antitumor agents
ITMI971851A1 (it) Derivati di ammino-acridine carbossiammidi aventi attivita' antitumorale
WO1992015307A1 (en) 6,9-BIS(AMINO SUBSTITUTED)BENZO[g]PHTHALAZINE-5,10-DIONES AS ANTITUMOR AGENTS

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead