CA2094117A1 - Tachykinin receptor antagonists, isoquinolones and their production - Google Patents
Tachykinin receptor antagonists, isoquinolones and their productionInfo
- Publication number
- CA2094117A1 CA2094117A1 CA002094117A CA2094117A CA2094117A1 CA 2094117 A1 CA2094117 A1 CA 2094117A1 CA 002094117 A CA002094117 A CA 002094117A CA 2094117 A CA2094117 A CA 2094117A CA 2094117 A1 CA2094117 A1 CA 2094117A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- substituted
- group
- compound
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9529192 | 1992-04-15 | ||
| JP095291/1992 | 1992-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2094117A1 true CA2094117A1 (en) | 1993-10-16 |
Family
ID=14133676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002094117A Abandoned CA2094117A1 (en) | 1992-04-15 | 1993-04-15 | Tachykinin receptor antagonists, isoquinolones and their production |
Country Status (11)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0634402A1 (en) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinone derivatives, their production and use |
| TW263498B (US06235095-20010522-C00021.png) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US5770590A (en) * | 1995-03-24 | 1998-06-23 | Takeda Chemical Industries, Ltd. | Cyclic compounds, their prudiction and use |
| DE69628484T2 (de) * | 1995-03-24 | 2004-05-19 | Takeda Chemical Industries, Ltd. | Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten |
| WO2003068750A1 (fr) * | 2002-02-13 | 2003-08-21 | Takeda Chemical Industries, Ltd. | Inhibiteur de jnk |
| AU2004276267B2 (en) * | 2003-09-23 | 2010-08-19 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| CA2539546C (en) * | 2003-09-23 | 2010-07-13 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
| WO2013004766A1 (en) | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| AU2019223237A1 (en) | 2018-02-26 | 2020-09-03 | Ospedale San Raffaele S.R.L. | NK-1 antagonists for use in the treatment of ocular pain |
| EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2647902A (en) * | 1951-02-16 | 1953-08-04 | Smith Kline French Lab | Method for the preparation of tetrahydroisoquinolone derivatives |
| US2809969A (en) * | 1955-11-07 | 1957-10-15 | Bristol Lab Inc | Isoquinolone derivatives |
| US3247212A (en) * | 1963-03-19 | 1966-04-19 | Dow Chemical Co | Thio substituted 3 amino isoquinolines |
| US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
| DE2030675A1 (en) * | 1969-06-23 | 1971-02-11 | Arthur D Little, Inc , Cambridge, Mass (V St A) | 3-amino-4-phenyl-isoquinoline derivs |
| IL45823A (en) * | 1973-10-20 | 1977-10-31 | Hoechst Ag | Substituted 1-phenyl-4-alkyl(dialkyl or cyclic) aminoalkyl-1,4-dihydro-2h-isoquinoline-3-one derivatives |
| TW205037B (US06235095-20010522-C00021.png) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| US5143919A (en) * | 1990-08-17 | 1992-09-01 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their pharmaceutical use |
| JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びａｃａｔ阻害剤 |
| EP0481383B1 (en) * | 1990-10-16 | 1995-06-28 | Takeda Chemical Industries, Ltd. | Heterocyclic amine derivatives, their production and use |
-
1993
- 1993-03-30 TW TW082102343A patent/TW241258B/zh active
- 1993-03-31 NZ NZ247302A patent/NZ247302A/en unknown
- 1993-04-01 AU AU35663/93A patent/AU657045B2/en not_active Ceased
- 1993-04-13 US US08/045,219 patent/US5523305A/en not_active Expired - Fee Related
- 1993-04-14 EP EP93106015A patent/EP0566069A1/en not_active Withdrawn
- 1993-04-14 NO NO931364A patent/NO179550C/no unknown
- 1993-04-14 FI FI931682A patent/FI931682A/fi not_active Application Discontinuation
- 1993-04-14 HU HU9301080A patent/HUT70148A/hu unknown
- 1993-04-14 KR KR1019930006221A patent/KR930021202A/ko not_active IP Right Cessation
- 1993-04-15 CN CN93105950A patent/CN1083054A/zh active Pending
- 1993-04-15 CA CA002094117A patent/CA2094117A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU3566393A (en) | 1993-10-21 |
| HUT70148A (en) | 1995-09-28 |
| CN1083054A (zh) | 1994-03-02 |
| NZ247302A (en) | 1994-12-22 |
| FI931682A (fi) | 1993-10-16 |
| AU657045B2 (en) | 1995-02-23 |
| TW241258B (US06235095-20010522-C00021.png) | 1995-02-21 |
| EP0566069A1 (en) | 1993-10-20 |
| HU9301080D0 (en) | 1993-06-28 |
| FI931682A0 (fi) | 1993-04-14 |
| NO179550C (no) | 1996-10-30 |
| NO931364D0 (no) | 1993-04-14 |
| NO931364L (no) | 1993-10-18 |
| US5523305A (en) | 1996-06-04 |
| NO179550B (no) | 1996-07-22 |
| KR930021202A (ko) | 1993-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |