CA2083683A1 - Formulation stable a base de sel d'analapril; methode de preparation et utilisation - Google Patents
Formulation stable a base de sel d'analapril; methode de preparation et utilisationInfo
- Publication number
- CA2083683A1 CA2083683A1 CA2083683A CA2083683A CA2083683A1 CA 2083683 A1 CA2083683 A1 CA 2083683A1 CA 2083683 A CA2083683 A CA 2083683A CA 2083683 A CA2083683 A CA 2083683A CA 2083683 A1 CA2083683 A1 CA 2083683A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- salt
- sodium
- stable formulation
- analapril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical class C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 150000003388 sodium compounds Chemical class 0.000 abstract 1
- FTTHROYWFRGKST-BDURURIASA-M sodium;(2s)-1-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate Chemical class [Na+].C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C([O-])=O)CC1=CC=CC=C1 FTTHROYWFRGKST-BDURURIASA-M 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU184291A YU48602B (sh) | 1991-11-25 | 1991-11-25 | Postupak za dobijanje stabilne formulacije soli enalaprila |
| YUP-1842/91 | 1991-11-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2083683A1 true CA2083683A1 (fr) | 1993-05-26 |
| CA2083683C CA2083683C (fr) | 2000-09-05 |
Family
ID=25555813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002083683A Expired - Fee Related CA2083683C (fr) | 1991-11-25 | 1992-11-24 | Formulation stable a base de sel d'analapril; methode de preparation et utilisation |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5350582A (fr) |
| EP (1) | EP0545194B1 (fr) |
| AT (1) | ATE150650T1 (fr) |
| CA (1) | CA2083683C (fr) |
| DE (1) | DE69218557T2 (fr) |
| DK (1) | DK0545194T3 (fr) |
| ES (1) | ES2101004T3 (fr) |
| GR (1) | GR3023655T3 (fr) |
| HR (1) | HRP921482B1 (fr) |
| SI (1) | SI9111842A (fr) |
| YU (1) | YU48602B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2128199C (fr) * | 1994-07-15 | 1997-02-04 | Bernard Charles Sherman | Compositions pharmaceutiques, solides, stables, renfermant du maleate d'enalapril |
| US5573780A (en) * | 1995-08-04 | 1996-11-12 | Apotex Usa Inc. | Stable solid formulation of enalapril salt and process for preparation thereof |
| GB9521781D0 (en) * | 1995-10-24 | 1996-01-03 | Merck Sharp & Dohme | Therapeutic agents |
| ES2125198B1 (es) * | 1997-05-13 | 1999-11-16 | Vita Invest Sa | Asociacion a dosis fija de un inhibidor de la enzima convertidora de angiotensina y de un antagonista de los canales de calcio, procedimiento para su preparacion y su utilizacion para el tratamiento de enfermees cardiovasculares. |
| CA2302832A1 (fr) * | 1998-07-21 | 2000-02-03 | Kaneka Corporation | Procede de cristallisation d'un sel d'acide maleique de n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline |
| NZ333206A (en) | 1998-12-08 | 2000-07-28 | Bernard Charles Sherman | Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor |
| US6637359B1 (en) * | 1998-12-15 | 2003-10-28 | Maritrans Inc. | System and method for internally fitting a new inner hull to an existing outer hull to form a rebuilt double hull vessel |
| US6764694B1 (en) * | 1999-08-31 | 2004-07-20 | Mutual Pharmaceutical Co., Inc. | Stable formulations of ACE inhibitors, and methods for preparation thereof |
| US6555551B1 (en) | 1999-08-31 | 2003-04-29 | Mutual Pharmaceutical Co., Inc. | Stable formulations of ACE inhibitors, and methods for preparation thereof |
| US20040157911A1 (en) * | 1999-08-31 | 2004-08-12 | Spiridon Spireas | Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof |
| US20030225124A1 (en) * | 1999-08-31 | 2003-12-04 | Spiridon Spireas | Stable formulations of ACE inhibitors, and methods for preparation thereof |
| HU226950B1 (en) * | 1999-11-03 | 2010-03-29 | Richter Gedeon Nyrt | The magnesium salt of enalapril and antihypertensive pharmaceutical composition containing it |
| US20030215526A1 (en) * | 2002-03-08 | 2003-11-20 | Scott Stofik | Stable formulations of angiotensin converting enzyme (ACE) inhibitors |
| JP4948392B2 (ja) * | 2004-03-29 | 2012-06-06 | レ ラボラトア セルビエ | 固形薬学的組成物を調製するためのプロセス |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| RS53324B (en) | 2005-11-17 | 2014-10-31 | Silverstone Pharma Est. | STABLE FORMULATION OF AMORPHIC SALES OF PERINDOPRIL, PROCEDURE FOR THEIR PREPARATION, IN PARTICULAR INDUSTRIAL PREPARATION, AND THEIR USE IN HYPERTENSION THERAPY |
| SI23149A (sl) | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
| WO2011161223A2 (fr) | 2010-06-23 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Formes pharmaceutiques à usage oral comprenant de la lercanidipine et de l'énalapril et leurs sels pharmaceutiquement acceptables |
| EP2654729B1 (fr) | 2010-12-24 | 2016-05-04 | KRKA, d.d., Novo mesto | Formes pharmaceutiques orales homogènes comprenant de la lercanidipine et de l'énalapril ou leurs sels pharmaceutiquement acceptables ainsi qu'un acide organique |
| CA2922536C (fr) | 2013-08-28 | 2022-05-03 | Psychemedics Corporation | Test d'integrite d'echantillons de cheveux |
| RS58120B1 (sr) | 2014-07-31 | 2019-02-28 | Pharmathen Sa | Kompozicija orodisperzibilnog filma koja sadrži enalapril za lečenje hipertenzije kod pedijatrijske populacije |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4830853A (en) * | 1986-10-20 | 1989-05-16 | Warner-Lambert Company | Drug compositions stabilized against oxidation |
| US4743450A (en) * | 1987-02-24 | 1988-05-10 | Warner-Lambert Company | Stabilized compositions |
| EP0391462A1 (fr) * | 1989-04-05 | 1990-10-10 | Janssen Pharmaceutica N.V. | Combinaisons synergiques à kétanserin |
-
1991
- 1991-11-25 SI SI9111842A patent/SI9111842A/sl unknown
- 1991-11-25 YU YU184291A patent/YU48602B/sh unknown
-
1992
- 1992-11-23 ES ES92119896T patent/ES2101004T3/es not_active Expired - Lifetime
- 1992-11-23 DK DK92119896.6T patent/DK0545194T3/da active
- 1992-11-23 DE DE69218557T patent/DE69218557T2/de not_active Expired - Lifetime
- 1992-11-23 AT AT92119896T patent/ATE150650T1/de not_active IP Right Cessation
- 1992-11-23 EP EP92119896A patent/EP0545194B1/fr not_active Expired - Lifetime
- 1992-11-24 US US07/980,956 patent/US5350582A/en not_active Expired - Fee Related
- 1992-11-24 CA CA002083683A patent/CA2083683C/fr not_active Expired - Fee Related
- 1992-12-30 HR HRP-1842/91A patent/HRP921482B1/xx not_active IP Right Cessation
-
1997
- 1997-06-04 GR GR970401299T patent/GR3023655T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0545194A1 (fr) | 1993-06-09 |
| GR3023655T3 (en) | 1997-09-30 |
| DE69218557D1 (de) | 1997-04-30 |
| CA2083683C (fr) | 2000-09-05 |
| ATE150650T1 (de) | 1997-04-15 |
| HRP921482B1 (en) | 2000-04-30 |
| YU184291A (sh) | 1994-04-05 |
| DK0545194T3 (da) | 1997-07-28 |
| EP0545194B1 (fr) | 1997-03-26 |
| HRP921482A2 (en) | 1996-12-31 |
| US5350582A (en) | 1994-09-27 |
| DE69218557T2 (de) | 1997-11-13 |
| YU48602B (sh) | 1998-12-23 |
| ES2101004T3 (es) | 1997-07-01 |
| SI9111842A (sl) | 1998-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2083683A1 (fr) | Formulation stable a base de sel d'analapril; methode de preparation et utilisation | |
| DE3460577D1 (en) | Sodium salt of ursodeoxycholic sulphate | |
| CS144791A3 (en) | Novel sulfonyl compounds | |
| CA2138825A1 (fr) | Compositions de rincage | |
| CA2047783A1 (fr) | Solution stable d'hypochlorite de sodium | |
| ES8308864A1 (es) | Procedimiento para la fabricacion de nuevos derivados aminoalcoxi aromaticos. | |
| EP0138616A3 (fr) | Nona- et décapeptides pour augmenter l'activité naturelle de destruction de cellules, leurs procédés d'obtention et compositions pharmaceutiques les contenant | |
| AU5188393A (en) | 15-deoxyspergualin analogs, their method of preparation and their use in therapeutics | |
| HU901193D0 (en) | Process for protection against phytopathogenic bacteria using phosphonic acid derivatives | |
| JPS5517319A (en) | Preparation of eugenol zinc salt | |
| MY110751A (en) | Positive inotropic and lusitropic pyrroloquinolinone derivatives | |
| JPS57188515A (en) | Stabilized aqueous dopamine preparation | |
| ES8601209A1 (es) | Procedimiento para preparar derivados de 5h-(1)-benzopirano-(2,3-d)pirimidina | |
| ES8403911A1 (es) | Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0 | |
| CA2143216A1 (fr) | Analogues de la 15-deoxyspergualine, leur preparation et leur utilisation therapeutique | |
| AU6701096A (en) | Process for the manufacturing of iodinated contrast agents | |
| ES8506641A1 (es) | Procedimiento para preparar 1-acetonil-2-(fenilimino)-imidazolidinas | |
| CA2076772A1 (fr) | Nouvelle analogues de la vitamine d3 | |
| ES8205219A1 (es) | Un metodo para producir un compuesto de hidrouracilo | |
| ES8501380A1 (es) | Un procedimiento para preparar l-tiazolidin-4-carboxilato de zinc | |
| IL71068A0 (en) | N-arylpiperazine derivative,its preparation and pharmaceutical compositions containing it | |
| ES8504829A1 (es) | Un procedimiento para la preparacion de un acido -hidroxietilfosfinico | |
| EP0364928A3 (fr) | Composition de pâte de dentifrice | |
| DE69608260D1 (en) | Wässrige spectinomycinborat-auflösung | |
| ES8500266A1 (es) | "procedimiento para la preparacion de nuevos acidos benzoilparabanicos" |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |