CA2050597A1 - Urea based lipoxygenase inhibiting compounds - Google Patents
Urea based lipoxygenase inhibiting compoundsInfo
- Publication number
- CA2050597A1 CA2050597A1 CA002050597A CA2050597A CA2050597A1 CA 2050597 A1 CA2050597 A1 CA 2050597A1 CA 002050597 A CA002050597 A CA 002050597A CA 2050597 A CA2050597 A CA 2050597A CA 2050597 A1 CA2050597 A1 CA 2050597A1
- Authority
- CA
- Canada
- Prior art keywords
- hydroxy
- urea
- carbon atoms
- thien
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/08—Naphthothiopyrans; Hydrogenated naphthothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33156689A | 1989-03-30 | 1989-03-30 | |
US331,566 | 1989-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2050597A1 true CA2050597A1 (en) | 1990-10-01 |
Family
ID=23294495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002050597A Abandoned CA2050597A1 (en) | 1989-03-30 | 1990-03-20 | Urea based lipoxygenase inhibiting compounds |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0588785A1 (ja) |
JP (1) | JPH04504261A (ja) |
CA (1) | CA2050597A1 (ja) |
GR (1) | GR900100231A (ja) |
WO (1) | WO1990012008A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084575A (en) * | 1987-07-31 | 1992-01-28 | American Home Products Corporation | Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents |
US5120752A (en) * | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
US5220059A (en) * | 1990-04-19 | 1993-06-15 | Abbott Laboratories | Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
GB9012252D0 (en) * | 1990-06-01 | 1990-07-18 | Lilly Industries Ltd | Pharmaceutical compounds |
WO1992001682A1 (en) * | 1990-07-25 | 1992-02-06 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
US5476873A (en) * | 1990-07-25 | 1995-12-19 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
DE4023742A1 (de) * | 1990-07-26 | 1992-01-30 | Gruenenthal Gmbh | Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
JPH06256285A (ja) * | 1990-12-11 | 1994-09-13 | Pfizer Pharmaceut Co Ltd | ヒドロキサム酸誘導体およびその用途 |
US5130485A (en) * | 1991-04-23 | 1992-07-14 | Eli Lilly And Company | N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents |
US5283361A (en) * | 1991-04-23 | 1994-02-01 | Eli Lilly And Company | N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors |
US5214204A (en) * | 1991-07-19 | 1993-05-25 | Abbott Laboratories | Arylamidoalkyl-n-hydroxyurea compounds having lipoxygenase inhibitory activity |
DE4124345A1 (de) * | 1991-07-23 | 1993-01-28 | Gruenenthal Gmbh | Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
DE4204686A1 (de) * | 1992-02-17 | 1993-08-19 | Gruenenthal Gmbh | Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln |
US5468760A (en) * | 1993-11-08 | 1995-11-21 | American Home Products Corporation | Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein |
US5428048A (en) * | 1993-11-08 | 1995-06-27 | American Home Products Corporation | Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents |
US5459154A (en) * | 1993-11-08 | 1995-10-17 | American Home Products Corporation | N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein |
US5506261A (en) * | 1994-05-09 | 1996-04-09 | Abbott Laboratories | Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis |
US5612377A (en) * | 1994-08-04 | 1997-03-18 | Minnesota Mining And Manufacturing Company | Method of inhibiting leukotriene biosynthesis |
WO1996023772A1 (fr) * | 1995-02-02 | 1996-08-08 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree |
EP1085010B1 (en) * | 1998-06-04 | 2004-03-10 | Kumiai Chemical Industry Co., Ltd. | Phenylacetylene derivatives and agricultural/horticultural bactericides |
CN1980920A (zh) * | 2004-06-14 | 2007-06-13 | 霍夫曼-拉罗奇有限公司 | 噻吩衍生物、它们的制备以及作为药剂的应用 |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
CA2926950C (en) | 2013-10-10 | 2022-10-11 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU506399B2 (en) * | 1975-12-30 | 1980-01-03 | Showa Denko Kabushiki Kaisha | 3-(2-aryl-2-propyl) ureas |
DE2936410A1 (de) * | 1979-09-08 | 1981-03-26 | Agfa-Gevaert Ag, 51373 Leverkusen | Verfahren zur stabilisierung farbphotographischer materialien sowie farbphotographisches material |
US4618692A (en) * | 1981-09-03 | 1986-10-21 | Asta-Werke Aktiengesellschaft | 4-carbamoyloxy-oxazaphosphorins |
US4607053A (en) * | 1984-05-17 | 1986-08-19 | E. R. Squibb & Sons, Inc. | Arylhydroxamates useful as antiallergy agents |
US4728670A (en) * | 1986-06-04 | 1988-03-01 | E. R. Squibb & Sons, Inc. | Biphenyl hydroxamic acids |
EP0292699B1 (en) * | 1987-04-24 | 1994-03-23 | Abbott Laboratories | Urea based lipoxygenase inhibiting compounds |
-
1990
- 1990-03-20 EP EP90906504A patent/EP0588785A1/en not_active Withdrawn
- 1990-03-20 JP JP2506101A patent/JPH04504261A/ja active Pending
- 1990-03-20 CA CA002050597A patent/CA2050597A1/en not_active Abandoned
- 1990-03-20 WO PCT/US1990/001488 patent/WO1990012008A1/en not_active Application Discontinuation
- 1990-03-28 GR GR900100231A patent/GR900100231A/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR900100231A (el) | 1991-07-31 |
EP0588785A1 (en) | 1994-03-30 |
WO1990012008A1 (en) | 1990-10-18 |
EP0588785A4 (en) | 1991-12-30 |
JPH04504261A (ja) | 1992-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2050597A1 (en) | Urea based lipoxygenase inhibiting compounds | |
EP0667855B1 (en) | Substituted arylalkynyl- and heteroarylalkynyl-n-hydroxyurea inhibitors of leukotriene biosynthesis | |
MXPA04005864A (es) | Derivados de charcona y su uso para tratar enfermedades. | |
US20040181075A1 (en) | Process of making chalcone derivatives | |
US6727239B1 (en) | Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them | |
CA2200981A1 (en) | Urea derivatives and their use as acat-inhibitors | |
US9777015B2 (en) | Useful thiophene derivatives in the treatment of diabetes | |
JPH06500557A (ja) | ロイコトリエン生合成を阻害するインドール誘導体 | |
JP2599665B2 (ja) | ピラジン誘導体 | |
EP1641758B1 (fr) | Derives de diphenylpyridine, leur preparation et leur application therapeutique | |
AU638303B2 (en) | Cyclopropyl derivative lipoxygenase inhibitors | |
US5037853A (en) | Cyclopropyl derivative lipoxygenase inhibitors | |
CA1319689C (en) | Substituted alkylamine derivatives | |
KR20070045330A (ko) | 대식 세포 엘라스타아제의 억제제인5-[3-(4-벤질옥시페닐티오)-퓨르-2-일]-이미다졸리딘-2,4-디온 및 유사 화합물 | |
US5185363A (en) | Urea based lipoxygenase inhibiting compounds | |
US5516789A (en) | Lipoxygenase and cyclooxygenase inhibiting compounds | |
RU2404966C2 (ru) | Замещенное акриламидное производное и фармацевтическая композиция на его основе | |
KR850001318B1 (ko) | 1h-1,2,4-트리아졸 유도체의 제조방법 | |
EP1615629A1 (en) | Peptide deformylase inhibitors | |
CA2004754A1 (en) | Alpha-cyano-beta-oxopropionamides | |
WO1994014762A1 (en) | Oxime ether derivatives having lipoxygenase inhibitory activity | |
RU2181722C2 (ru) | Способ получения и промежуточные соединения для получения ингибиторов 5-липоксигеназы | |
JP2003533506A (ja) | N−置換ペプチジルニトリル | |
JPH0789953A (ja) | 製薬化合物 | |
JPH07173143A (ja) | 新規2−チオキソ−4−チアゾリジノン誘導体及び医薬 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |