CA2021942C - Couplage d'un agent anti-tumoral a un anticorps au moyen d'une glytaraldehyde preactivee - Google Patents
Couplage d'un agent anti-tumoral a un anticorps au moyen d'une glytaraldehyde preactivee Download PDFInfo
- Publication number
- CA2021942C CA2021942C CA002021942A CA2021942A CA2021942C CA 2021942 C CA2021942 C CA 2021942C CA 002021942 A CA002021942 A CA 002021942A CA 2021942 A CA2021942 A CA 2021942A CA 2021942 C CA2021942 C CA 2021942C
- Authority
- CA
- Canada
- Prior art keywords
- daunorubicin
- glutaraldehyde
- antibody
- conjugate
- doxorubicin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39192889A | 1989-08-10 | 1989-08-10 | |
US391,928 | 1989-08-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2021942A1 CA2021942A1 (fr) | 1991-02-11 |
CA2021942C true CA2021942C (fr) | 2001-04-10 |
Family
ID=23548555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002021942A Expired - Lifetime CA2021942C (fr) | 1989-08-10 | 1990-07-25 | Couplage d'un agent anti-tumoral a un anticorps au moyen d'une glytaraldehyde preactivee |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2021942C (fr) |
WO (1) | WO1991001757A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19636889A1 (de) | 1996-09-11 | 1998-03-12 | Felix Dr Kratz | Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5843926A (ja) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | 選択性制癌剤 |
GB2116979B (en) * | 1982-02-25 | 1985-05-15 | Ward Page Faulk | Conjugates of proteins with anti-tumour agents |
JPS59134732A (ja) * | 1983-01-21 | 1984-08-02 | Green Cross Corp:The | フイブロネクチン・生理活性物質複合体の製造法 |
JPS59186924A (ja) * | 1983-04-08 | 1984-10-23 | Kureha Chem Ind Co Ltd | ヒト免疫グロブリン結合抗腫瘍剤 |
US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
-
1990
- 1990-07-25 CA CA002021942A patent/CA2021942C/fr not_active Expired - Lifetime
- 1990-08-09 WO PCT/CA1990/000251 patent/WO1991001757A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
CA2021942A1 (fr) | 1991-02-11 |
WO1991001757A1 (fr) | 1991-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5208323A (en) | Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent | |
US4699784A (en) | Tumoricidal methotrexate-antibody conjugate | |
KR960015398B1 (ko) | 신규의 링커를 갖는 안트라사이클린 면역결합체 및 그의 제조방법 | |
AU767394B2 (en) | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use | |
ES2623017T3 (es) | Procedimiento para la preparación de una formulación medicamentosa inyectable | |
US4401592A (en) | Pharmaceutical composition having antitumor activity | |
US4046722A (en) | Immunological materials | |
US5004606A (en) | Non-covalent antibody-anthracycline immunocomplexes | |
FI98197C (fi) | Menetelmä sytotoksisten aineiden kasvainsoluihin toimittamiseen käyttökelpoisen vasta-aine-entsyymikonjugaatin valmistamiseksi | |
PT99954B (pt) | Processo de preparacao de moleculas de ligacao labeis aos acidos e de composicoes farmaceuticas | |
KR20160045146A (ko) | 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 | |
EA010508B1 (ru) | Способ прицельного воздействия на определенные популяции клеток с помощью конъюгатов из майтансиноида и агента клеточного связывания, соединенных через нерасщепляемый линкер, конъюгаты и способы получения таких конъюгатов | |
US5514794A (en) | Antibody-drug conjugates | |
DE102005009084A1 (de) | Proteinbindende Anthrazyklin-Peptid-Derivate und diese enthaltende Arzneimittel | |
US4485093A (en) | Immunotoxin conjugate which comprises arsanilic acid, useful for treating malignant tumors, particularly pancreatic cancer | |
KR20220038601A (ko) | 캄토테신 약물 및 그의 항체 접합체 | |
KR900017597A (ko) | 신규의 링커를 갖는 안트라사이클린 결합체 및 그의 제조방법 | |
CA2101809A1 (fr) | Conjugues de drogues cytotoxiques pour le traitement des neoplasies | |
CA2021942C (fr) | Couplage d'un agent anti-tumoral a un anticorps au moyen d'une glytaraldehyde preactivee | |
CN114053426A (zh) | 一种双药链接组装单元及双药靶向接头-药物偶联物 | |
RU2106147C1 (ru) | Конъюгат производного 14-бромдаунорубицина с моноклональным антителом или его фрагментом, обладающий противоопухолевой активностью и имеющий специфичность к данной опухоли, и фармацевтическая композиция, обладающая противоопухолевой активностью | |
Wilchek | Affinity therapy and polymer bound drugs | |
HU221857B1 (hu) | Eljárás antraciklin-konjugátumok és ilyen vegyületeket tartalmazó gyógyászati készítmények előállítására | |
CN113941007B (zh) | 一种串联的双药物链接组装单元及其应用 | |
Sweet et al. | Daunorubicin conjugated to a monoclonal anti-CA125 antibody selectively kills human ovarian cancer cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |