CA2011282A1 - Steroid diols, pharmaceutical compositions containing them and process for preparing same - Google Patents

Steroid diols, pharmaceutical compositions containing them and process for preparing same

Info

Publication number
CA2011282A1
CA2011282A1 CA002011282A CA2011282A CA2011282A1 CA 2011282 A1 CA2011282 A1 CA 2011282A1 CA 002011282 A CA002011282 A CA 002011282A CA 2011282 A CA2011282 A CA 2011282A CA 2011282 A1 CA2011282 A1 CA 2011282A1
Authority
CA
Canada
Prior art keywords
alpha
hydrogen
stands
general formula
dion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002011282A
Other languages
English (en)
French (fr)
Inventor
Jozsef Toth
Arpad Kiraly
Anna Boor
Janos Csorgei
Krisztina Szekely
Lilla Forgacs
Gyorgy Fekete
Bulcsu Herenyi
Sandor Holly
Jozsef Szunyog
Csaba Molnar
Gyorgy Hajos
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2011282A1 publication Critical patent/CA2011282A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002011282A 1989-03-09 1990-03-01 Steroid diols, pharmaceutical compositions containing them and process for preparing same Abandoned CA2011282A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1156/89 1989-03-09
HU891156A HU203562B (en) 1989-03-09 1989-03-09 Process for producing new steroide diols and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
CA2011282A1 true CA2011282A1 (en) 1990-09-09

Family

ID=10953088

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002011282A Abandoned CA2011282A1 (en) 1989-03-09 1990-03-01 Steroid diols, pharmaceutical compositions containing them and process for preparing same

Country Status (17)

Country Link
US (1) US5082835A (instruction)
EP (1) EP0387091A3 (instruction)
JP (1) JPH06104679B2 (instruction)
KR (1) KR930009445B1 (instruction)
CN (1) CN1045396A (instruction)
AR (1) AR244700A1 (instruction)
AU (1) AU623503B2 (instruction)
CA (1) CA2011282A1 (instruction)
EG (1) EG19411A (instruction)
FI (1) FI901199A7 (instruction)
HU (1) HU203562B (instruction)
IL (1) IL93478A (instruction)
IN (1) IN170846B (instruction)
NO (1) NO177147C (instruction)
PH (1) PH26676A (instruction)
PT (1) PT93375A (instruction)
ZA (1) ZA901752B (instruction)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
FR2675146A1 (fr) * 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
ES2528403T3 (es) 2005-04-28 2015-02-09 Proteus Digital Health, Inc. Sistemas informáticos farmacéuticos
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN110078785A (zh) * 2019-06-04 2019-08-02 博诺康源(北京)药业科技有限公司 一种布地奈德杂质ep-ze的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167545A (en) * 1959-02-07 1965-01-26 Syntex Corp 16beta-methyl-16alpha, 17 alpha-dihydroxy pregnenes and the 16alpha, 17alpha-cyclic ketals and acetals thereof
US3345362A (en) * 1961-07-27 1967-10-03 Lilly Co Eli Novel pregnenolone acetonides
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
WO1989001482A1 (en) * 1987-08-14 1989-02-23 The Upjohn Company IMPROVED 9alpha-DEHALOGENATION PROCESS

Also Published As

Publication number Publication date
NO901103D0 (no) 1990-03-08
IL93478A (en) 1994-11-11
PT93375A (pt) 1990-11-07
AR244700A1 (es) 1993-11-30
JPH02279695A (ja) 1990-11-15
FI901199A0 (fi) 1990-03-09
NO901103L (no) 1990-09-10
EG19411A (en) 1995-01-31
AU623503B2 (en) 1992-05-14
ZA901752B (en) 1991-05-29
HU203562B (en) 1991-08-28
CN1045396A (zh) 1990-09-19
AU5110290A (en) 1990-09-13
KR930009445B1 (ko) 1993-10-04
PH26676A (en) 1992-09-15
JPH06104679B2 (ja) 1994-12-21
NO177147B (no) 1995-04-18
EP0387091A3 (en) 1992-05-06
EP0387091A2 (en) 1990-09-12
KR900014422A (ko) 1990-10-23
FI901199A7 (fi) 1990-09-10
US5082835A (en) 1992-01-21
NO177147C (no) 1995-07-26
IL93478A0 (en) 1990-11-29
IN170846B (instruction) 1992-05-30

Similar Documents

Publication Publication Date Title
US3983233A (en) Compositions and method of treating with stereoisomeric mixtures of 2-unsymmetrical 16,17-methylenedioxy steroids
IE45023B1 (en) Androstadiene-17-carboxylic acids and their esters
JPS6140648B2 (instruction)
US4172132A (en) 1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
JPS6058999A (ja) ステロイド系カルボン酸エステル及びこれを含有する医薬
CA2011282A1 (en) Steroid diols, pharmaceutical compositions containing them and process for preparing same
KR850001208B1 (ko) 17α-아실옥시-5β-코르티코이드 및 17α-아실옥시-5α-코르티코이드의 제조방법
US4024131A (en) 16-Methyl-9α-halo steroid esters, ethers and preparation thereof
HU190746B (en) Process for producing 6-alpha-methyl-corticoides and pharmaceutical compositions containing them
US5053404A (en) Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same
HK16683A (en) 21-halogenopregnane compounds
AP141A (en) Novel steroid doils.
GB1594852A (en) Derivatives of 9-chloroprednisolone
US4011315A (en) 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
EP0077541B1 (de) Delta-1,3,5-3-Chlor-11-Beta,16-Alpha,17-Alpha,21-tetra-(hydroxy)-pregnan-20-on-16,17-acetonidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4185101A (en) 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
EP0000609B1 (en) Novel 19-nor-pregnahexaenes, process for the preparation thereof, and pharmaceutical compositions containing them
GB1589585A (en) 12a-halocorticoids
JPS6150960B2 (instruction)
NO791143L (no) 4,6-dihalogensteroider, og fremgangsmaate til deres fremstilling
EP0004772A2 (en) 4-Halo etianic acids and derivatives thereof, their pharmaceutical use and preparation
PL121467B1 (en) Process for preparing novel corticoids
CS244663B2 (cs) Způsob výroby nových derivátů 9-chlorprednisolonu
CS207754B2 (cs) Způsob výroby v poloze 17 substituovaných lljS-hydroxystcroidů substituovaných lljS-hydroxystcroidů
CS202593B2 (cs) Způsob výroby derivátů 9-fluorprednisolonu

Legal Events

Date Code Title Description
FZDE Discontinued