CA1340738C - Derives du glycidol optiquement actifs - Google Patents

Derives du glycidol optiquement actifs

Info

Publication number
CA1340738C
CA1340738C CA 540572 CA540572A CA1340738C CA 1340738 C CA1340738 C CA 1340738C CA 540572 CA540572 CA 540572 CA 540572 A CA540572 A CA 540572A CA 1340738 C CA1340738 C CA 1340738C
Authority
CA
Canada
Prior art keywords
compound
purified
formula
purity
recrystallized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 540572
Other languages
English (en)
Inventor
Karl Barry Sharpless
Janice Klunder
Tetsuo H. Onami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/913,936 external-priority patent/US4946974A/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of CA1340738C publication Critical patent/CA1340738C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
CA 540572 1986-06-25 1987-06-25 Derives du glycidol optiquement actifs Expired - Fee Related CA1340738C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87817686A 1986-06-25 1986-06-25
US878,176 1986-06-25
US913,936 1986-10-01
US07/913,936 US4946974A (en) 1986-10-01 1986-10-01 Optically active derivatives of glycidol

Publications (1)

Publication Number Publication Date
CA1340738C true CA1340738C (fr) 1999-09-14

Family

ID=27128478

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 540572 Expired - Fee Related CA1340738C (fr) 1986-06-25 1987-06-25 Derives du glycidol optiquement actifs

Country Status (2)

Country Link
CA (1) CA1340738C (fr)
WO (1) WO1988000190A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468211B (sv) * 1990-01-22 1992-11-23 Nobel Chemicals Ab Flerstegsfoerfarande foer framstaellning av homokirala aminer
GB9001832D0 (en) * 1990-01-26 1990-03-28 Ici Plc Optical resolution
US5194637A (en) * 1991-08-22 1993-03-16 Syracuse University Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives
MXPA05002622A (es) 2002-09-09 2005-09-08 Johnson & Johnson Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano.
US8703948B2 (en) 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CA2683598C (fr) 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv Derives de 1,3,8-trisubstitue-1,3,8-triaza-spiro[4.5]decan-4-one utilises comme ligands du recepteur orl-i dans le traitement de l'anxiete et de la depression

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2755290A (en) * 1953-10-26 1956-07-17 Shell Dev Esters of sulfonic acids and certain epoxy-substituted alcohols and method for theirpreparation
SE354851B (fr) * 1970-02-18 1973-03-26 Haessle Ab
US4145442A (en) * 1972-04-04 1979-03-20 Aktiebolaget Hassle Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
US4471130A (en) * 1980-08-06 1984-09-11 The Board Of Trustees Of The Leland Stanford Junior University Method for asymmetric epoxidation
JPS5821692A (ja) * 1981-07-29 1983-02-08 Microbial Chem Res Found 新規アミノ配糖体
JPS60208973A (ja) * 1984-03-31 1985-10-21 Kowa Co 循環系疾患治療剤

Also Published As

Publication number Publication date
WO1988000190A1 (fr) 1988-01-14

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