CA1340615C - Compouds effective in inducing cell differentiation and process for preparing same - Google Patents

Compouds effective in inducing cell differentiation and process for preparing same

Info

Publication number
CA1340615C
CA1340615C CA000597715A CA597715A CA1340615C CA 1340615 C CA1340615 C CA 1340615C CA 000597715 A CA000597715 A CA 000597715A CA 597715 A CA597715 A CA 597715A CA 1340615 C CA1340615 C CA 1340615C
Authority
CA
Canada
Prior art keywords
hydroxy
compounds
compound
dihydroxyvitamin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000597715A
Other languages
English (en)
French (fr)
Inventor
Hector F. Deluca
Heinrich K. Schnoes
Kato L. Perlman
Andrzej Kutner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of CA1340615C publication Critical patent/CA1340615C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000597715A 1988-04-29 1989-06-25 Compouds effective in inducing cell differentiation and process for preparing same Expired - Fee Related CA1340615C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/187,680 1988-04-29
US07/187,680 US4927815A (en) 1988-04-29 1988-04-29 Compounds effective in inducing cell differentiation and process for preparing same

Publications (1)

Publication Number Publication Date
CA1340615C true CA1340615C (en) 1999-06-29

Family

ID=22690003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000597715A Expired - Fee Related CA1340615C (en) 1988-04-29 1989-06-25 Compouds effective in inducing cell differentiation and process for preparing same

Country Status (15)

Country Link
US (2) US4927815A (US20100012521A1-20100121-C00001.png)
EP (1) EP0375757A1 (US20100012521A1-20100121-C00001.png)
JP (2) JPH0725730B2 (US20100012521A1-20100121-C00001.png)
KR (1) KR930011151B1 (US20100012521A1-20100121-C00001.png)
AU (1) AU630096B2 (US20100012521A1-20100121-C00001.png)
CA (1) CA1340615C (US20100012521A1-20100121-C00001.png)
DK (2) DK666589A (US20100012521A1-20100121-C00001.png)
FR (1) FR2630740A1 (US20100012521A1-20100121-C00001.png)
GB (1) GB2217715A (US20100012521A1-20100121-C00001.png)
HU (1) HU206083B (US20100012521A1-20100121-C00001.png)
IE (1) IE67868B1 (US20100012521A1-20100121-C00001.png)
IL (1) IL90066A (US20100012521A1-20100121-C00001.png)
IN (1) IN170659B (US20100012521A1-20100121-C00001.png)
NL (1) NL8920414A (US20100012521A1-20100121-C00001.png)
WO (1) WO1989010353A1 (US20100012521A1-20100121-C00001.png)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250523A (en) * 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
CA1339383C (en) * 1989-03-09 1997-08-26 Hector Floyd Deluca Method for preparing intermediates for the synthesis of steroid side chains in optically active form
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
US5459136A (en) * 1990-08-24 1995-10-17 Wisconsin Alumni Research Foundation Methods using vitamin D compounds for improvement of skin conditions
US5276061A (en) * 1990-08-24 1994-01-04 Wisconsin Alumni Research Foundation Cosmetic compositions containing 1α-hydroxyvitamin D homologs
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
US5380720A (en) * 1993-05-11 1995-01-10 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
PE28297A1 (es) * 1995-01-26 1997-08-20 Hoffmann La Roche Empleo dermatologico de derivados de vitamina d
US5744128A (en) * 1995-05-03 1998-04-28 Holick; Michael F. Use of emu oil for stimulating skin and hair growth
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
AUPO727097A0 (en) * 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
US6521608B1 (en) 1998-03-27 2003-02-18 Oregon Health & Science University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
PT1180035E (pt) * 1999-04-01 2007-02-28 Univ Johns Hopkins Análogos não calcémicos, antiproliferativos, transcricionalmente activos de 1-alfa, 25-di-hidroxivitamina d3 contendo enxofre
WO2001040177A2 (en) 1999-12-02 2001-06-07 Women And Infants Hospital Esters of vitamin d3 and uses thereof
US7166585B2 (en) * 2001-08-22 2007-01-23 Cytochroma Inc. 24-Sulfur-substituted analogs of 1α,25-dihydroxy vitamin D3
AU2003262179A1 (en) * 2002-04-11 2003-10-27 Instytut Farmaceutyczny Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
BRPI0508333A (pt) * 2004-03-01 2007-07-17 Bioxell Spa uso de um composto de vitamina d, método de prevenir e/ou tratar cistite intersticial, formulação farmacêutica, composto de vitamina d, e, kit
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
WO2008131267A2 (en) * 2007-04-18 2008-10-30 Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
SG178382A1 (en) 2009-08-14 2012-04-27 Berg Biosystems Llc Vitamin d3 and analogs thereof for treating alopecia
WO2012065050A1 (en) 2010-11-12 2012-05-18 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN110981765A (zh) * 2019-11-07 2020-04-10 肇庆巨元生化有限公司 一种25-羟基维生素d3中间体的制备方法
CN112920096A (zh) * 2019-12-05 2021-06-08 四川大学 一种制备2-甲基-4-(苯磺酰基)-2-丁醇的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8520265A (nl) * 1984-10-04 1986-09-01 Wisconsin Alumni Res Found Derivaten van vitamine d en werkwijzen voor het bereiden daarvan.
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DE68907483T2 (de) * 1988-04-21 1993-10-21 Leo Pharm Prod Ltd Vitamin d analoge.
RU2057117C1 (ru) * 1988-04-29 1996-03-27 Висконсин Алюмни Рисерч Фаундейшн ГОМОЛОГИ 1α - ГИДРОКСИВИТАМИНА D3 С НЕНАСЫЩЕННОЙ БОКОВОЙ ЦЕПЬЮ, КОМПОЗИЦИЯ, СПОСОБСТВУЮЩАЯ СТИМУЛЯЦИИ И УСИЛЕНИЮ ДИФФЕРЕНЦИАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ЛЕЙКЕМИИ ЧЕЛОВЕКА, СПОСОБ СТИМУЛЯЦИИ И УСИЛЕНИЯ ДИФФЕРЕНЦИАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ЛЕЙКЕМИИ ЧЕЛОВЕКА

Also Published As

Publication number Publication date
HUT52475A (en) 1990-07-28
IE67868B1 (en) 1996-05-01
JPH02504154A (ja) 1990-11-29
KR930011151B1 (ko) 1993-11-24
KR900700449A (ko) 1990-08-13
IL90066A0 (en) 1989-12-15
NL8920414A (nl) 1990-04-02
DK89091D0 (da) 1991-05-13
HU206083B (en) 1992-08-28
WO1989010353A1 (en) 1989-11-02
HU892989D0 (en) 1990-06-28
AU3573089A (en) 1989-11-24
IN170659B (US20100012521A1-20100121-C00001.png) 1992-05-02
JPH0725730B2 (ja) 1995-03-22
DK666589D0 (da) 1989-12-22
DK89091A (da) 1991-05-13
FR2630740A1 (fr) 1989-11-03
IL90066A (en) 1995-12-08
US4927815A (en) 1990-05-22
JPH0748343A (ja) 1995-02-21
US5061699A (en) 1991-10-29
GB8909570D0 (en) 1989-06-14
EP0375757A1 (en) 1990-07-04
AU630096B2 (en) 1992-10-22
DK666589A (da) 1990-02-28
GB2217715A (en) 1989-11-01
JP2505713B2 (ja) 1996-06-12
IE891406L (en) 1989-10-29

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MKLA Lapsed
MKLA Lapsed

Effective date: 20030630