CA1329359C - Process and an apparatus for crystallizing a substance dissolved in a liquid in zero gravity - Google Patents
Process and an apparatus for crystallizing a substance dissolved in a liquid in zero gravityInfo
- Publication number
- CA1329359C CA1329359C CA000536474A CA536474A CA1329359C CA 1329359 C CA1329359 C CA 1329359C CA 000536474 A CA000536474 A CA 000536474A CA 536474 A CA536474 A CA 536474A CA 1329359 C CA1329359 C CA 1329359C
- Authority
- CA
- Canada
- Prior art keywords
- space
- liquid
- retaining elements
- sphere
- quasi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 79
- 239000000126 substance Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title abstract description 22
- 230000008569 process Effects 0.000 title abstract description 18
- 230000005484 gravity Effects 0.000 title abstract description 11
- 239000000463 material Substances 0.000 claims description 5
- 206010038776 Retching Diseases 0.000 claims 1
- 239000013078 crystal Substances 0.000 abstract description 20
- 238000002425 crystallisation Methods 0.000 abstract description 13
- 230000008025 crystallization Effects 0.000 abstract description 12
- 230000007847 structural defect Effects 0.000 abstract description 6
- 230000000717 retained effect Effects 0.000 abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 6
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 6
- 235000011130 ammonium sulphate Nutrition 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 229930195733 hydrocarbon Natural products 0.000 description 5
- 150000002430 hydrocarbons Chemical class 0.000 description 5
- 239000004215 Carbon black (E152) Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000001133 acceleration Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- -1 e.g. Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000005486 microgravity Effects 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- MFYMCCBGVQYQIX-UHFFFAOYSA-L P.[Cl-].[Cl-].Cl.Cl.Cl.[Ca+2] Chemical compound P.[Cl-].[Cl-].Cl.Cl.Cl.[Ca+2] MFYMCCBGVQYQIX-UHFFFAOYSA-L 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- NNNSKJSUQWKSAM-UHFFFAOYSA-L magnesium;dichlorate Chemical compound [Mg+2].[O-]Cl(=O)=O.[O-]Cl(=O)=O NNNSKJSUQWKSAM-UHFFFAOYSA-L 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B30/00—Production of single crystals or homogeneous polycrystalline material with defined structure characterised by the action of electric or magnetic fields, wave energy or other specific physical conditions
- C30B30/08—Production of single crystals or homogeneous polycrystalline material with defined structure characterised by the action of electric or magnetic fields, wave energy or other specific physical conditions in conditions of zero-gravity or low gravity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10S117/901—Levitation, reduced gravity, microgravity, space
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Peptides Or Proteins (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863615541 DE3615541A1 (de) | 1986-05-07 | 1986-05-07 | Verfahren und vorrichtung zur auskristallisation einer in einer fluessigkeit geloesten substanz im zustand der schwerelosigkeit |
| DEP3615541.1-45 | 1986-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1329359C true CA1329359C (en) | 1994-05-10 |
Family
ID=6300394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000536474A Expired - Fee Related CA1329359C (en) | 1986-05-07 | 1987-05-06 | Process and an apparatus for crystallizing a substance dissolved in a liquid in zero gravity |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4960572A (enExample) |
| EP (1) | EP0244867B1 (enExample) |
| JP (1) | JPS62282601A (enExample) |
| CA (1) | CA1329359C (enExample) |
| DE (2) | DE3615541A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3806635A1 (de) * | 1988-03-02 | 1989-09-14 | Battelle Institut E V | Verfahren zum zuechten eines einkristalls |
| DE3806634A1 (de) * | 1988-03-02 | 1989-09-14 | Battelle Institut E V | Verfahren zum zuechten eines einkristalls |
| DE3941099A1 (de) * | 1989-12-13 | 1991-06-20 | Dornier Gmbh | Handhabung von fluessigkeiten unter schwerelosigkeit |
| DE4007943C1 (en) * | 1990-03-13 | 1991-03-07 | Erno Raumfahrttechnik Gmbh, 2800 Bremen, De | Appts. for weightless crystallisation - has sprung piston spray ejector forming droplet at tip |
| US5427335A (en) * | 1992-07-13 | 1995-06-27 | The University Of Tennessee Research Corporation | Method for producing extreme microgravity in extended volumes |
| JPH07275690A (ja) * | 1994-04-05 | 1995-10-24 | Mitsubishi Electric Corp | 浮遊装置 |
| JPH0834699A (ja) * | 1994-07-25 | 1996-02-06 | Fujitsu Ltd | 生体高分子結晶化装置 |
| US5643540A (en) * | 1995-02-27 | 1997-07-01 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Protein crystal growth apparatus for microgravitiy |
| US7479859B2 (en) * | 2006-03-08 | 2009-01-20 | Jack Gerber | Apparatus and method for processing material in a magnetic vortex |
| DE102007020671A1 (de) | 2007-05-01 | 2008-11-06 | Justus-Liebig-Universität Giessen | Verfahren und Vorrichtung zum kontaktfreien Materialwachstum in einer strömenden Lösung (FLow suspended solution growth (FSSG)) |
| ES2310131B1 (es) | 2007-06-04 | 2009-12-04 | INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" | Procedimiento de cristalizacion a partir de solucion. |
| KR102797400B1 (ko) * | 2024-04-26 | 2025-04-21 | 주식회사 스페이스린텍 | 미세 중력 환경에서의 단백질 결정화 장치 및 이를 이용하여 단백질을 결정화하는 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1095208A (en) * | 1912-07-10 | 1914-05-05 | Alfred H Humphrey | Gas-lamp. |
| US1736437A (en) * | 1927-09-22 | 1929-11-19 | Visible Night And Day Street N | Street sign |
| US1746340A (en) * | 1928-04-14 | 1930-02-11 | Miller Co | Dustproof cover for reflectors |
| US1854020A (en) * | 1930-11-24 | 1932-04-12 | Gen Electric | Adjustable support |
| US3425584A (en) * | 1966-10-19 | 1969-02-04 | California Texas Oil Corp | Shipboard mounting liquefied gas tanks |
| US3713560A (en) * | 1971-04-19 | 1973-01-30 | Gen Dynamics Corp | Spaced wall container |
| US4046617A (en) * | 1975-09-05 | 1977-09-06 | Nasa | Method of crystallization |
| DE3024127C2 (de) * | 1980-06-27 | 1983-09-29 | Deutsche Forschungs- und Versuchsanstalt für Luft- und Raumfahrt e.V., 5000 Köln | Vorrichtung zur beschleunigungsfreien Anbringung eines Körpers in einem Raumfahrzeug |
| FR2509637A1 (fr) * | 1981-07-17 | 1983-01-21 | Commissariat Energie Atomique | Procede de sustentation, de positionnement et de moulage sans contact de masses liquides permettant la solidification en forme de materiaux et application de ce procede a la mise en forme de materiaux en microgravite |
| JPH089520B2 (ja) * | 1983-05-25 | 1996-01-31 | 理化学研究所 | 薄膜単結晶の製造方法 |
-
1986
- 1986-05-07 DE DE19863615541 patent/DE3615541A1/de active Granted
-
1987
- 1987-05-06 CA CA000536474A patent/CA1329359C/en not_active Expired - Fee Related
- 1987-05-07 JP JP62109934A patent/JPS62282601A/ja active Granted
- 1987-05-07 DE DE8787106664T patent/DE3772835D1/de not_active Expired - Fee Related
- 1987-05-07 EP EP87106664A patent/EP0244867B1/de not_active Expired - Lifetime
-
1988
- 1988-09-19 US US07/248,234 patent/US4960572A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3615541A1 (de) | 1987-11-12 |
| EP0244867A2 (de) | 1987-11-11 |
| DE3615541C2 (enExample) | 1988-11-17 |
| US4960572A (en) | 1990-10-02 |
| EP0244867B1 (de) | 1991-09-11 |
| DE3772835D1 (de) | 1991-10-17 |
| EP0244867A3 (en) | 1989-07-19 |
| JPH0443880B2 (enExample) | 1992-07-17 |
| JPS62282601A (ja) | 1987-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |