CA1302259C - Pharmaceutical formulations - Google Patents
Pharmaceutical formulationsInfo
- Publication number
- CA1302259C CA1302259C CA000546905A CA546905A CA1302259C CA 1302259 C CA1302259 C CA 1302259C CA 000546905 A CA000546905 A CA 000546905A CA 546905 A CA546905 A CA 546905A CA 1302259 C CA1302259 C CA 1302259C
- Authority
- CA
- Canada
- Prior art keywords
- controlled release
- dosage form
- unit
- density
- units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 3
- 238000013270 controlled release Methods 0.000 claims abstract description 82
- 239000002552 dosage form Substances 0.000 claims abstract description 60
- 210000002784 stomach Anatomy 0.000 claims abstract description 56
- 230000002496 gastric effect Effects 0.000 claims abstract description 39
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 28
- 239000002775 capsule Substances 0.000 claims abstract description 26
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims abstract description 18
- 239000007787 solid Substances 0.000 claims abstract description 10
- 239000004480 active ingredient Substances 0.000 claims description 66
- 239000008188 pellet Substances 0.000 claims description 58
- 239000011230 binding agent Substances 0.000 claims description 57
- 239000011248 coating agent Substances 0.000 claims description 17
- 238000000576 coating method Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 239000004615 ingredient Substances 0.000 claims description 10
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 8
- 241000282412 Homo Species 0.000 claims description 7
- 239000005557 antagonist Substances 0.000 claims description 4
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000002503 metabolic effect Effects 0.000 claims description 4
- 206010053567 Coagulopathies Diseases 0.000 claims description 3
- 230000000840 anti-viral effect Effects 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 230000035602 clotting Effects 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000000926 neurological effect Effects 0.000 claims description 3
- 125000003259 prostaglandin group Chemical group 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 49
- 229940079593 drug Drugs 0.000 description 26
- 239000003814 drug Substances 0.000 description 26
- 239000000463 material Substances 0.000 description 24
- 239000000203 mixture Substances 0.000 description 19
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 17
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 12
- 235000013305 food Nutrition 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 230000002035 prolonged effect Effects 0.000 description 10
- 210000000936 intestine Anatomy 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 210000001035 gastrointestinal tract Anatomy 0.000 description 8
- 239000012530 fluid Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 6
- 239000001856 Ethyl cellulose Substances 0.000 description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 6
- 235000019325 ethyl cellulose Nutrition 0.000 description 6
- 229920001249 ethyl cellulose Polymers 0.000 description 6
- 230000030136 gastric emptying Effects 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 6
- 239000002151 riboflavin Substances 0.000 description 6
- 235000019192 riboflavin Nutrition 0.000 description 6
- 229960002477 riboflavin Drugs 0.000 description 6
- 230000009885 systemic effect Effects 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- -1 colourants Substances 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 210000002249 digestive system Anatomy 0.000 description 4
- 238000007455 ileostomy Methods 0.000 description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 4
- 239000008108 microcrystalline cellulose Substances 0.000 description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 229920003152 Eudragit® RS polymer Polymers 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 229940097320 beta blocking agent Drugs 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 description 3
- 239000003163 gonadal steroid hormone Substances 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 150000003180 prostaglandins Chemical class 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000009747 swallowing Effects 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 229940124549 vasodilator Drugs 0.000 description 3
- 239000003071 vasodilator agent Substances 0.000 description 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000003288 anthiarrhythmic effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- 230000000648 anti-parkinson Effects 0.000 description 2
- 230000002467 anti-pepsin effect Effects 0.000 description 2
- 230000000702 anti-platelet effect Effects 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 229940030600 antihypertensive agent Drugs 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 229960005475 antiinfective agent Drugs 0.000 description 2
- 239000000939 antiparkinson agent Substances 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 239000000812 cholinergic antagonist Substances 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 230000000112 colonic effect Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 229940030606 diuretics Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 239000000395 magnesium oxide Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 229920005615 natural polymer Polymers 0.000 description 2
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 2
- 238000005453 pelletization Methods 0.000 description 2
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- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8622482 | 1986-09-18 | ||
| GB868622482A GB8622482D0 (en) | 1986-09-18 | 1986-09-18 | Pharmaceutical formulation |
| GB878708011A GB8708011D0 (en) | 1987-04-03 | 1987-04-03 | Pharmaceutical formulation |
| GB8708011 | 1987-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1302259C true CA1302259C (en) | 1992-06-02 |
Family
ID=26291305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000546905A Expired - Lifetime CA1302259C (en) | 1986-09-18 | 1987-09-15 | Pharmaceutical formulations |
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| CH (1) | CH674146A5 (forum.php) |
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| HU (1) | HU202101B (forum.php) |
| IL (1) | IL83897A (forum.php) |
| IT (1) | IT1211484B (forum.php) |
| NZ (1) | NZ221805A (forum.php) |
| PT (1) | PT85747B (forum.php) |
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| US4983400A (en) * | 1986-06-16 | 1991-01-08 | Merck & Co., Inc. | Controlled release combination of carbidopa/levodopa |
| US5374430A (en) * | 1986-09-18 | 1994-12-20 | London School Of Pharmacy | Pharmaceutical formulation |
| GB8707416D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
| IE64726B1 (en) * | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| IE63986B1 (en) * | 1989-12-30 | 1995-06-28 | Akzo Nv | Pharmaceutical preparation for oral administration in fluid form |
| DK165090D0 (da) * | 1990-07-09 | 1990-07-09 | Kem En Tec As | Konglomererede partikler |
| GB9018839D0 (en) * | 1990-08-29 | 1990-10-10 | Newton John M | Slow release compositions |
| US5166145A (en) * | 1990-09-10 | 1992-11-24 | Alza Corporation | Antiemetic therapy |
| SE9101149D0 (sv) | 1991-04-17 | 1991-04-17 | Pharmacia Lkb Biotech | Beads for down stream processing |
| US5198229A (en) * | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
| US5252337A (en) * | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
| US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
| IT1251153B (it) * | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
| US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
| MX9304638A (es) * | 1992-07-31 | 1994-05-31 | Neose Pharm Inc | Composicion para tratar e inhibir las ulceras gastricas y duodenales. |
| WO1994003184A1 (en) * | 1992-07-31 | 1994-02-17 | Neose Pharmaceuticals, Inc. | Compositions for treating and inhibiting gastric and duodenal ulcers |
| ATE186544T1 (de) * | 1992-08-04 | 1999-11-15 | James M Dunn | Pharmazeutische formulierungen mit kontrollierter freigabe von 3'-azido-3'-deoxythymidin und verfahren zur verwendung |
| FR2703908B1 (fr) * | 1993-04-13 | 1995-06-02 | Asta Medica Ag | Forme pharmaceutique pour administration rectale de composés pharmacologiquement actifs. |
| US6706188B2 (en) | 1993-05-03 | 2004-03-16 | Amersham Biociences Ab | Process and means for down stream processing |
| US8828432B2 (en) * | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
| US7179486B1 (en) | 1997-04-01 | 2007-02-20 | Nostrum Pharmaceuticals, Inc. | Process for preparing sustained release tablets |
| EP1900283A3 (en) * | 1998-03-23 | 2010-02-10 | General Mills, Inc. | Encapsulation of components into edible products |
| US10973397B2 (en) | 1999-03-01 | 2021-04-13 | West View Research, Llc | Computerized information collection and processing apparatus |
| US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
| US20050079214A1 (en) * | 1999-09-01 | 2005-04-14 | John Cooker | Oral delivery system and method for making same |
| US20040101540A1 (en) * | 1999-09-01 | 2004-05-27 | John Cooker | Oral delivery system and method for making same |
| US6437000B1 (en) | 1999-09-02 | 2002-08-20 | Norstrum Pharmaceuticals, Inc. | Controlled release oral dosage for suitable for oral administration |
| US20060153914A1 (en) * | 1999-12-10 | 2006-07-13 | Biovail Laboratories International S.R.L. | Chronotherapeutic diltiazem formulations and the administration thereof |
| US7108866B1 (en) | 1999-12-10 | 2006-09-19 | Biovall Laboratories International Srl | Chronotherapeutic diltiazem formulations and the administration thereof |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| WO2001080831A2 (en) | 2000-04-27 | 2001-11-01 | Verion Inc. | Zero order release and temperature-controlled microcapsules and process for the preparation thereof |
| DE10031043A1 (de) | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US20110171296A1 (en) * | 2000-10-30 | 2011-07-14 | Biohit Oyj | Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine |
| FI121528B (fi) * | 2000-10-30 | 2010-12-31 | Biohit Oyj | Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa |
| US6569808B2 (en) * | 2001-07-30 | 2003-05-27 | Lee F. Klinger | Methods and compositions useful for bryophyte remediation to improve forest health and growth |
| AUPR951501A0 (en) * | 2001-12-14 | 2002-01-24 | Smart Drug Systems Inc | Modified sustained release pharmaceutical system |
| US7131997B2 (en) | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
| US7094369B2 (en) | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| GB0214013D0 (en) * | 2002-06-18 | 2002-07-31 | Euro Celtique Sa | Pharmaceutical product |
| US20040029959A1 (en) * | 2002-08-08 | 2004-02-12 | John Devane | Isosorbide mononitrate compositions and methods of their use |
| US20040076582A1 (en) * | 2002-08-30 | 2004-04-22 | Dimatteo Kristian | Agent delivery particle |
| US8012454B2 (en) * | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
| US20070102672A1 (en) * | 2004-12-06 | 2007-05-10 | Hamilton Judd D | Ceramic radiation shielding material and method of preparation |
| US20080107727A1 (en) * | 2005-01-31 | 2008-05-08 | Katashi Nakashima | Multiple Unit Oral Sustained Release Preparation and Production Method Thereof |
| US20070087056A1 (en) * | 2005-08-09 | 2007-04-19 | Claudia Guthmann | Pharmaceutical form with sustained pH-independent active ingredient release for active ingredients having strong pH-dependent solubility |
| US7803413B2 (en) | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc. | Encapsulation of readily oxidizable components |
| SI1976532T1 (sl) | 2006-01-27 | 2016-04-29 | Yale University | Hitro delujoči zaviralec izločanja želodčne kisline |
| US8512761B2 (en) | 2006-01-27 | 2013-08-20 | Yale University | Fast acting inhibitor of gastric acid secretion |
| CN101984745B (zh) * | 2007-09-07 | 2013-08-14 | Qlt股份有限公司 | 用于持续释放治疗药物的药物核心 |
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| WO2010100414A1 (en) * | 2009-03-04 | 2010-09-10 | Orexo Ab | Abuse resistant formulation |
| CN102421419B (zh) | 2009-05-08 | 2016-05-04 | 奥瑞克索股份公司 | 用于持续药物传递的包含地聚合物粘合剂的组合物 |
| CN102458138B (zh) * | 2009-06-05 | 2014-08-20 | 通用工厂公司 | 用于制备烘烤食品的胶囊化的ω-3脂肪酸 |
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| WO2017111692A1 (en) * | 2015-12-21 | 2017-06-29 | Stockholm University | A solid form sampling tablet and its use for determining the amount of a specific analyte in a liquid sample. |
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| CA614091A (en) * | 1956-11-05 | 1961-02-07 | Commonwealth Scientific And Industrial Research Organization | Time delay pill for ruminant |
| GB936386A (en) * | 1959-01-16 | 1963-09-11 | Wellcome Found | Pellets for supplying biologically active substances to ruminants |
| CH582002A5 (forum.php) * | 1972-06-09 | 1976-11-30 | Purdue Research Foundation | |
| GB1590574A (en) * | 1976-08-06 | 1981-06-03 | Atomic Energy Authority Uk | Biologically active gels |
| GB1590573A (en) * | 1976-08-06 | 1981-06-03 | Atomic Energy Authority Uk | Biologically active gels |
| GB1576376A (en) * | 1977-03-30 | 1980-10-08 | Benzon As Alfred | Multiple-unit drug dose |
| GB2015875B (en) * | 1978-02-24 | 1982-10-20 | Novex Foreign Trade Co Ltd | Solid oral pharaceutical product with increased efficacy and predetermined steady state of solubility |
| JPS6024767B2 (ja) * | 1979-08-24 | 1985-06-14 | 塩野義製薬株式会社 | 腸溶性硬カプセル剤 |
| GR69960B (forum.php) * | 1979-09-12 | 1982-07-22 | Barbara Ellen Simpson | |
| GB2100602B (en) * | 1981-06-24 | 1984-11-14 | May & Baker Ltd | Device for delivering biologically active substances to the digestive tract. |
| ZA825384B (en) * | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
| GB2123690A (en) * | 1982-07-20 | 1984-02-08 | Nat Res Dev | Sustained release device |
| GB2123693B (en) * | 1982-07-20 | 1987-05-13 | Nat Res Dev | Sustained release device |
| DE3306250A1 (de) * | 1983-02-23 | 1984-08-23 | Basf Ag, 6700 Ludwigshafen | Sphaerische einkristalle fuer pharmazeutische zwecke |
| FR2560768A1 (fr) * | 1984-03-07 | 1985-09-13 | Crb Virbac Sa | Dispositif a liberation programmee |
| DE3431861A1 (de) * | 1984-08-30 | 1986-03-13 | Troponwerke GmbH & Co KG, 5000 Köln | Pellet-zubereitung |
| US4609374A (en) * | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
-
1987
- 1987-09-09 EP EP87307973A patent/EP0265061B1/en not_active Expired - Lifetime
- 1987-09-09 ES ES198787307973T patent/ES2038669T3/es not_active Expired - Lifetime
- 1987-09-09 DE DE87307973T patent/DE3775880D1/de not_active Expired - Lifetime
- 1987-09-09 AT AT87307973T patent/ATE71293T1/de active
- 1987-09-09 GB GB8721186A patent/GB2196252B/en not_active Expired - Lifetime
- 1987-09-14 NZ NZ221805A patent/NZ221805A/xx unknown
- 1987-09-14 IL IL83897A patent/IL83897A/xx not_active IP Right Cessation
- 1987-09-15 CA CA000546905A patent/CA1302259C/en not_active Expired - Lifetime
- 1987-09-15 FR FR8712782A patent/FR2604090B1/fr not_active Expired - Lifetime
- 1987-09-17 CH CH3591/87A patent/CH674146A5/fr not_active IP Right Cessation
- 1987-09-17 DK DK488287A patent/DK488287A/da not_active Application Discontinuation
- 1987-09-17 AU AU78481/87A patent/AU606353B2/en not_active Ceased
- 1987-09-17 HU HU874139A patent/HU202101B/hu not_active IP Right Cessation
- 1987-09-17 PT PT85747A patent/PT85747B/pt not_active IP Right Cessation
- 1987-09-17 US US07/097,943 patent/US4938967A/en not_active Expired - Fee Related
- 1987-09-17 IT IT8767796A patent/IT1211484B/it active
- 1987-09-17 BE BE8701047A patent/BE1000616A5/fr not_active IP Right Cessation
- 1987-09-18 KR KR1019870010376A patent/KR890004686B1/ko not_active Expired
-
1992
- 1992-04-02 GR GR920400623T patent/GR3004268T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB8721186D0 (en) | 1987-10-14 |
| FR2604090B1 (fr) | 1990-06-15 |
| AU606353B2 (en) | 1991-02-07 |
| IT1211484B (it) | 1989-11-03 |
| HU202101B (en) | 1991-02-28 |
| NZ221805A (en) | 1991-02-26 |
| IL83897A (en) | 1991-06-10 |
| IL83897A0 (en) | 1988-02-29 |
| DK488287D0 (da) | 1987-09-17 |
| GR3004268T3 (forum.php) | 1993-03-31 |
| ATE71293T1 (de) | 1992-01-15 |
| US4938967A (en) | 1990-07-03 |
| HUT45194A (en) | 1988-06-28 |
| EP0265061A1 (en) | 1988-04-27 |
| GB2196252A (en) | 1988-04-27 |
| EP0265061B1 (en) | 1992-01-08 |
| FR2604090A1 (fr) | 1988-03-25 |
| BE1000616A5 (fr) | 1989-02-21 |
| PT85747A (en) | 1987-10-01 |
| DK488287A (da) | 1988-03-19 |
| AU7848187A (en) | 1988-03-24 |
| CH674146A5 (forum.php) | 1990-05-15 |
| DE3775880D1 (forum.php) | 1992-02-20 |
| PT85747B (pt) | 1991-02-08 |
| IT8767796A0 (it) | 1987-09-17 |
| KR890004686B1 (ko) | 1989-11-25 |
| GB2196252B (en) | 1990-10-17 |
| KR880003617A (ko) | 1988-05-28 |
| ES2038669T3 (es) | 1993-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |