CA1297458C - Method for improved uniformity in dispensing - Google Patents
Method for improved uniformity in dispensingInfo
- Publication number
- CA1297458C CA1297458C CA000499043A CA499043A CA1297458C CA 1297458 C CA1297458 C CA 1297458C CA 000499043 A CA000499043 A CA 000499043A CA 499043 A CA499043 A CA 499043A CA 1297458 C CA1297458 C CA 1297458C
- Authority
- CA
- Canada
- Prior art keywords
- container
- liquid
- pressure
- dispensing
- signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 54
- 230000003213 activating effect Effects 0.000 claims abstract description 3
- 230000008859 change Effects 0.000 claims description 8
- 208000036366 Sensation of pressure Diseases 0.000 abstract description 8
- 230000000875 corresponding effect Effects 0.000 abstract description 4
- 206010052804 Drug tolerance Diseases 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 26
- 238000012360 testing method Methods 0.000 description 20
- 230000005499 meniscus Effects 0.000 description 7
- 230000007423 decrease Effects 0.000 description 6
- 206010003504 Aspiration Diseases 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 230000009850 completed effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000013022 venting Methods 0.000 description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 241000479907 Devia <beetle> Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000001660 aspiration Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/1083—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with one horizontal degree of freedom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Auxiliary Methods And Devices For Loading And Unloading (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US718,319 | 1985-04-01 | ||
| US06/718,319 US4675301A (en) | 1985-04-01 | 1985-04-01 | Method for correcting for changes in air pressure above a liquid to be dispensed from a container mounted on a probe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1297458C true CA1297458C (en) | 1992-03-17 |
Family
ID=24885665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000499043A Expired - Fee Related CA1297458C (en) | 1985-04-01 | 1986-01-06 | Method for improved uniformity in dispensing |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4675301A (enExample) |
| EP (1) | EP0199466B1 (enExample) |
| JP (1) | JPS61231463A (enExample) |
| CA (1) | CA1297458C (enExample) |
| DE (1) | DE3673549D1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3614955C1 (de) * | 1986-05-02 | 1987-08-06 | Schulz Peter | Proben-Verteiler-System |
| JPS62299769A (ja) * | 1986-06-20 | 1987-12-26 | Fuji Photo Film Co Ltd | 分注器 |
| JPS6375565A (ja) * | 1986-09-18 | 1988-04-05 | Toshiba Corp | サンプリングモニタ |
| JPS63177530A (ja) * | 1987-01-19 | 1988-07-21 | Toshiba Corp | ダイボンデイング方法とその装置 |
| JPH076998B2 (ja) * | 1987-12-04 | 1995-01-30 | 富士写真フイルム株式会社 | 自動分注器および点着方法 |
| US4967606A (en) * | 1988-04-29 | 1990-11-06 | Caveo Scientific Instruments, Inc. | Method and apparatus for pipetting liquids |
| WO1989010193A1 (en) * | 1988-04-29 | 1989-11-02 | Cavro Scientific Instruments, Inc. | Improved method and apparatus for pipetting liquids |
| US5204269A (en) * | 1989-03-13 | 1993-04-20 | Beckman Instruments, Inc. | Sample handling for chemistry analyzers |
| US5089229A (en) | 1989-11-22 | 1992-02-18 | Vettest S.A. | Chemical analyzer |
| US5250262A (en) | 1989-11-22 | 1993-10-05 | Vettest S.A. | Chemical analyzer |
| JPH081471Y2 (ja) * | 1990-09-06 | 1996-01-17 | プレシジョン・システム・サイエンス株式会社 | 分注装置 |
| US5111703A (en) * | 1990-09-10 | 1992-05-12 | Eastman Kodak Company | Liquid aspirating pipette and dispensing system |
| US5409841A (en) * | 1991-03-14 | 1995-04-25 | Chow; Timothy | Ultraviolet light sterilized sampling device and method of sampling |
| US5143849A (en) * | 1991-03-21 | 1992-09-01 | Eastman Kodak Company | Tip to surface spacing for optimum dispensing controlled by a detected pressure change in the tip |
| US5133392A (en) * | 1991-04-10 | 1992-07-28 | Eastman Kodak Company | Liquid injection using container bottom sensing |
| JP2539126Y2 (ja) * | 1991-08-26 | 1997-06-25 | 東亜医用電子株式会社 | 自動調整機能を備えた試料吸引監視装置 |
| JP2515938B2 (ja) * | 1991-10-18 | 1996-07-10 | アロカ株式会社 | 液体の吸引方法 |
| US6849462B1 (en) | 1991-11-22 | 2005-02-01 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| US6943034B1 (en) | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| ATE293011T1 (de) * | 1991-11-22 | 2005-04-15 | Affymetrix Inc A Delaware Corp | Kombinatorische strategien für die polymersynthese |
| DE4209620C1 (de) * | 1992-03-25 | 1993-12-16 | Eppendorf Geraetebau Netheler | Verfahren zur Korrektur des Volumenfehlers ïV bei einem Pipettiersystem |
| FI96666C (fi) * | 1992-05-04 | 1996-08-12 | Wallac Oy | Menetelmä ja ilmamäntäpipetti nesteen annostelemiseksi |
| DE69320632T2 (de) * | 1992-06-08 | 1999-04-15 | Behring Diagnostics Inc., Westwood, Mass. | Flüssigkeitsspendersystem |
| JP3386505B2 (ja) * | 1993-03-02 | 2003-03-17 | 株式会社東芝 | 自動分析装置 |
| US5368196A (en) * | 1993-03-25 | 1994-11-29 | Fluid Management Limited Partnership | Apparatus for metering and dispensing flowable materials to form a blended composition |
| AU4982093A (en) * | 1993-08-31 | 1995-03-22 | Abbott Laboratories | Pipetting apparatus equipped with closure detection function |
| JP3420824B2 (ja) * | 1994-04-15 | 2003-06-30 | 富士写真フイルム株式会社 | 乾式分析フイルム片への試料液点着方法およびその装置 |
| US5503036A (en) * | 1994-05-09 | 1996-04-02 | Ciba Corning Diagnostics Corp. | Obstruction detection circuit for sample probe |
| US7323298B1 (en) | 1994-06-17 | 2008-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Microarray for determining the relative abundances of polynuceotide sequences |
| US7625697B2 (en) | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| CA2175001A1 (en) * | 1995-05-01 | 1996-11-02 | Andrew Shelley Foote | Method of avoiding decreased-size first drops when aspirating from immersed rest conditions |
| US5811306A (en) * | 1995-09-04 | 1998-09-22 | Fuji Photo Film Co., Ltd. | Liquid spotting method |
| US5965828A (en) * | 1995-12-14 | 1999-10-12 | Abbott Laboratories | Fluid handler and method of handling a fluid |
| US5723795A (en) * | 1995-12-14 | 1998-03-03 | Abbott Laboratories | Fluid handler and method of handling a fluid |
| US5915282A (en) * | 1995-12-14 | 1999-06-22 | Abbott Laboratories | Fluid handler and method of handling a fluid |
| JP2804951B2 (ja) * | 1996-02-23 | 1998-09-30 | 九州日本電気株式会社 | 精密定量吐出方法および吐出装置 |
| US5853665A (en) * | 1997-09-16 | 1998-12-29 | Coulter International Corp. | Apparatus and method for monitoring vent line vacuum |
| SE9803048D0 (sv) | 1998-09-09 | 1998-09-09 | Siemens Elema Ab | Dispenser unit for non-gaseous flowable material |
| AU2790300A (en) * | 1999-03-01 | 2000-09-21 | Sanjeev Chandra | Apparatus and method for generating droplets |
| US6370942B1 (en) | 2000-05-15 | 2002-04-16 | Dade Behring Inc. | Method for verifying the integrity of a fluid transfer |
| JP3903015B2 (ja) * | 2003-02-05 | 2007-04-11 | 株式会社日立ハイテクノロジーズ | 化学分析装置 |
| US7273591B2 (en) * | 2003-08-12 | 2007-09-25 | Idexx Laboratories, Inc. | Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same |
| WO2005036294A1 (en) * | 2003-10-06 | 2005-04-21 | Nordson Corporation | Compensating pressure controller for fluid dispenser and method |
| US7396512B2 (en) | 2003-11-04 | 2008-07-08 | Drummond Scientific Company | Automatic precision non-contact open-loop fluid dispensing |
| US7588733B2 (en) | 2003-12-04 | 2009-09-15 | Idexx Laboratories, Inc. | Retaining clip for reagent test slides |
| US7479391B2 (en) * | 2004-12-10 | 2009-01-20 | Tecan Trading Ag | Pipetting apparatus with integrated liquid level and/or gas bubble detection |
| EP1745851B1 (de) | 2005-07-22 | 2015-02-25 | Tecan Trading AG | Verfahren, Vorrichtung und Computerprogrammprodukt zum Klassifizieren einer Flüssigkeit |
| DE202006010293U1 (de) * | 2005-07-22 | 2006-08-31 | Tecan Trading Ag | Pipettiergerät mit Computerprogrammprodukt zum Akzeptieren oder Verwerfen von pipettierten Flüssigkeitsproben |
| WO2008140742A1 (en) * | 2007-05-08 | 2008-11-20 | Idexx Laboratories, Inc. | Chemical analyzer |
| JP2013076674A (ja) * | 2011-09-30 | 2013-04-25 | Fujifilm Corp | 分注装置および吸引ノズル位置制御方法 |
| DE102012209314B4 (de) | 2012-06-01 | 2015-04-02 | Albert-Ludwigs-Universität Freiburg | Vorrichtung und Verfahren zur Abgabe oder Aufnahme eines Flüssigkeitsvolumens |
| GB201212155D0 (en) | 2012-07-09 | 2012-08-22 | Stratec Biomedical Ag | A device and method for uptake or release of a liquid |
| US9797916B2 (en) | 2014-01-10 | 2017-10-24 | Idexx Laboratories, Inc. | Chemical analyzer |
| DE102017002046A1 (de) | 2017-03-03 | 2018-09-06 | aquila biolabs GmbH | Verfahren und Vorrichtung zur Dosierung und Aufbewahrung von Flüssigkeiten mittels permanent offener Behälter |
| WO2022011265A2 (en) | 2020-07-10 | 2022-01-13 | Idexx Laboratories Inc. | Point-of-care medical diagnostic analyzer and devices, systems, and methods for medical diagnostic analysis of samples |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE355076B (enExample) * | 1971-03-26 | 1973-04-02 | Aga Ab | |
| US3992158A (en) * | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
| US4041995A (en) * | 1975-01-30 | 1977-08-16 | Eastman Kodak Company | Gas pressure-activated drop dispenser |
| US4053381A (en) * | 1976-05-19 | 1977-10-11 | Eastman Kodak Company | Device for determining ionic activity of components of liquid drops |
| US4258001A (en) * | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
| US4287155A (en) * | 1980-06-16 | 1981-09-01 | Eastman Kodak Company | Sample tray and carrier for chemical analyzer |
| US4340390A (en) * | 1980-06-16 | 1982-07-20 | Eastman Kodak Company | Method and apparatus for metering biological fluids |
| US4452899A (en) * | 1982-06-10 | 1984-06-05 | Eastman Kodak Company | Method for metering biological fluids |
| CA1252173A (en) * | 1984-07-19 | 1989-04-04 | Thomas C. Jessop | Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid |
-
1985
- 1985-04-01 US US06/718,319 patent/US4675301A/en not_active Expired - Lifetime
-
1986
- 1986-01-06 CA CA000499043A patent/CA1297458C/en not_active Expired - Fee Related
- 1986-03-26 DE DE8686302223T patent/DE3673549D1/de not_active Expired - Lifetime
- 1986-03-26 EP EP86302223A patent/EP0199466B1/en not_active Expired - Lifetime
- 1986-04-01 JP JP61075395A patent/JPS61231463A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| US4675301A (en) | 1987-06-23 |
| DE3673549D1 (de) | 1990-09-27 |
| EP0199466B1 (en) | 1990-08-22 |
| EP0199466A3 (en) | 1987-08-19 |
| JPS61231463A (ja) | 1986-10-15 |
| JPH0355791B2 (enExample) | 1991-08-26 |
| EP0199466A2 (en) | 1986-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |