CA1283416C - Derives d'alkyl¬(carbamoyloxy)methyl|carbapenemes - Google Patents

Derives d'alkyl¬(carbamoyloxy)methyl|carbapenemes

Info

Publication number
CA1283416C
CA1283416C CA000523295A CA523295A CA1283416C CA 1283416 C CA1283416 C CA 1283416C CA 000523295 A CA000523295 A CA 000523295A CA 523295 A CA523295 A CA 523295A CA 1283416 C CA1283416 C CA 1283416C
Authority
CA
Canada
Prior art keywords
compound
alkyl
carboxylic acid
ester
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000523295A
Other languages
English (en)
Inventor
Shoichiro Uyeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of CA1283416C publication Critical patent/CA1283416C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
CA000523295A 1985-11-19 1986-11-18 Derives d'alkyl¬(carbamoyloxy)methyl|carbapenemes Expired - Fee Related CA1283416C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP260731/1985 1985-11-19
JP26073185 1985-11-19

Publications (1)

Publication Number Publication Date
CA1283416C true CA1283416C (fr) 1991-04-23

Family

ID=17351968

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000523295A Expired - Fee Related CA1283416C (fr) 1985-11-19 1986-11-18 Derives d'alkyl¬(carbamoyloxy)methyl|carbapenemes

Country Status (10)

Country Link
JP (1) JPS62201889A (fr)
KR (1) KR870004984A (fr)
AU (1) AU6534786A (fr)
BE (1) BE905784A (fr)
CA (1) CA1283416C (fr)
CH (1) CH671580A5 (fr)
DE (1) DE3639542C2 (fr)
FR (1) FR2590256B1 (fr)
GB (1) GB2183236B (fr)
IT (1) IT1195842B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292191A1 (fr) * 1987-05-21 1988-11-23 Merck & Co. Inc. Dérivés de 1-alkyl-carbapénème substitués en position 2 par un groupe méthylique substitué
JP2001514169A (ja) * 1997-08-27 2001-09-11 メルク エンド カムパニー インコーポレーテッド β−メチルカルバペネム中間体の製造
US6143885A (en) * 1997-08-27 2000-11-07 Merck & Co., Inc. Preparation of beta-methyl carbapenem intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
EP0184844A1 (fr) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Méthylcarbapénèmes ayant un substituant, relié par un pont alkylène-thio, en position 2

Also Published As

Publication number Publication date
CH671580A5 (fr) 1989-09-15
IT8667861A0 (it) 1986-11-19
IT1195842B (it) 1988-10-27
DE3639542C2 (de) 1995-07-13
JPS62201889A (ja) 1987-09-05
FR2590256B1 (fr) 1989-12-22
GB2183236A (en) 1987-06-03
GB2183236B (en) 1989-04-12
AU6534786A (en) 1987-05-21
GB8627656D0 (en) 1986-12-17
DE3639542A1 (de) 1987-05-21
FR2590256A1 (fr) 1987-05-22
KR870004984A (ko) 1987-06-04
BE905784A (fr) 1987-03-16

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