CA1259070A - Derives de substitution de 2-¬noyaux condenses (3,4- 4,5-, 5,6-)-pyridylalcoylenesulfinyl|- benzimidazoles - Google Patents

Derives de substitution de 2-¬noyaux condenses (3,4- 4,5-, 5,6-)-pyridylalcoylenesulfinyl|- benzimidazoles

Info

Publication number
CA1259070A
CA1259070A CA000456621A CA456621A CA1259070A CA 1259070 A CA1259070 A CA 1259070A CA 000456621 A CA000456621 A CA 000456621A CA 456621 A CA456621 A CA 456621A CA 1259070 A CA1259070 A CA 1259070A
Authority
CA
Canada
Prior art keywords
formula
compound
yield
chart
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000456621A
Other languages
English (en)
Inventor
John C. Sih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of CA1259070A publication Critical patent/CA1259070A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000456621A 1983-07-01 1984-06-14 Derives de substitution de 2-¬noyaux condenses (3,4- 4,5-, 5,6-)-pyridylalcoylenesulfinyl|- benzimidazoles Expired CA1259070A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51046883A 1983-07-01 1983-07-01
US510,468 1983-07-01

Publications (1)

Publication Number Publication Date
CA1259070A true CA1259070A (fr) 1989-09-05

Family

ID=24030850

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000456621A Expired CA1259070A (fr) 1983-07-01 1984-06-14 Derives de substitution de 2-¬noyaux condenses (3,4- 4,5-, 5,6-)-pyridylalcoylenesulfinyl|- benzimidazoles

Country Status (15)

Country Link
EP (1) EP0130729A3 (fr)
JP (1) JPS6036483A (fr)
KR (1) KR890000881B1 (fr)
AU (1) AU573744B2 (fr)
CA (1) CA1259070A (fr)
DK (1) DK321884A (fr)
ES (1) ES8601914A1 (fr)
FI (1) FI83514C (fr)
GR (1) GR81445B (fr)
IL (1) IL72159A (fr)
MX (1) MX161283A (fr)
NO (1) NO164472C (fr)
NZ (1) NZ208553A (fr)
PH (1) PH20625A (fr)
ZA (1) ZA844953B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3585252D1 (de) 1984-07-06 1992-03-05 Fisons Plc Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen.
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
EP0187977B1 (fr) * 1984-12-18 1990-08-29 Otsuka Pharmaceutical Co., Ltd. Dérivés de tétrahydroquinoline, leur procédé de préparation et compositions anti-ulcère gastrique les contenant
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
EP0204215B1 (fr) 1985-05-24 1993-08-11 G.D. Searle & Co. [(1H-benzimidazol-yl-2-sulfonyl)méthyl]-2-benzèneamines
FI864138A (fi) * 1985-10-16 1987-04-17 Fisons Plc Heterocykliska blandningar.
EP0239129B1 (fr) * 1986-03-28 1991-09-25 Otsuka Pharmaceutical Co., Ltd. Composés hydroquinoléine, compositions les contenant et procédé pour leur préparation
ATE56717T1 (de) * 1986-07-01 1990-10-15 Shionogi & Co Substituierte isoquinolinderivate und antiulcusmittel.
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
US4839365A (en) * 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
JPS6452782A (en) * 1987-05-19 1989-02-28 Shionogi & Co Thienopyridine derivative and antiulcer agent
WO1995029897A1 (fr) 1994-04-29 1995-11-09 G.D. Searle & Co. Procede d'utilisation d'inhibiteurs de (h+/k+)atpase comme agents antiviraux
WO1997000875A1 (fr) * 1995-06-21 1997-01-09 Korea Research Institute Of Chemical Technology Derives du benzimidazole contenant des pyridines fondues
ATE262332T1 (de) * 1995-09-21 2004-04-15 Pharma Pass Ii Llc Lansoprazolhaltige arzneizusammensetzung und herstellungsverfahren
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds

Also Published As

Publication number Publication date
FI842631A (fi) 1985-01-02
FI842631A0 (fi) 1984-06-29
GR81445B (fr) 1984-12-11
ES533853A0 (es) 1985-12-01
FI83514C (fi) 1991-07-25
IL72159A (en) 1987-12-31
DK321884D0 (da) 1984-06-29
JPS6036483A (ja) 1985-02-25
KR850001201A (ko) 1985-03-16
EP0130729A2 (fr) 1985-01-09
NO842645L (no) 1985-01-02
NO164472B (no) 1990-07-02
NO164472C (no) 1990-10-10
ES8601914A1 (es) 1985-12-01
PH20625A (en) 1987-03-06
AU573744B2 (en) 1988-06-23
EP0130729A3 (fr) 1986-08-06
AU2999684A (en) 1985-01-03
ZA844953B (en) 1985-02-27
NZ208553A (en) 1987-07-31
MX161283A (es) 1990-08-28
KR890000881B1 (ko) 1989-04-12
FI83514B (fi) 1991-04-15
DK321884A (da) 1985-01-02
IL72159A0 (en) 1984-10-31

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