CA1252790A - 4-aryl-4-piperidinecarbinols - Google Patents
4-aryl-4-piperidinecarbinolsInfo
- Publication number
- CA1252790A CA1252790A CA000427534A CA427534A CA1252790A CA 1252790 A CA1252790 A CA 1252790A CA 000427534 A CA000427534 A CA 000427534A CA 427534 A CA427534 A CA 427534A CA 1252790 A CA1252790 A CA 1252790A
- Authority
- CA
- Canada
- Prior art keywords
- carbon atoms
- alkyl
- aryl
- bridge
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37622982A | 1982-05-07 | 1982-05-07 | |
| US376,229 | 1982-05-07 | ||
| US468,040 | 1983-02-25 | ||
| US06/468,040 US4485109A (en) | 1982-05-07 | 1983-02-25 | 4-Aryl-4-piperidinecarbinols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1252790A true CA1252790A (en) | 1989-04-18 |
Family
ID=27007350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000427534A Expired CA1252790A (en) | 1982-05-07 | 1983-05-05 | 4-aryl-4-piperidinecarbinols |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4485109A (OSRAM) |
| EP (1) | EP0094018B1 (OSRAM) |
| AU (1) | AU560166B2 (OSRAM) |
| CA (1) | CA1252790A (OSRAM) |
| DE (1) | DE3375915D1 (OSRAM) |
| DK (1) | DK161699C (OSRAM) |
| ES (1) | ES522120A0 (OSRAM) |
| FI (1) | FI78685C (OSRAM) |
| GR (1) | GR77502B (OSRAM) |
| HU (1) | HU188278B (OSRAM) |
| IE (1) | IE55994B1 (OSRAM) |
| IL (1) | IL68586A0 (OSRAM) |
| NO (1) | NO162817C (OSRAM) |
| NZ (1) | NZ204150A (OSRAM) |
| PH (1) | PH18380A (OSRAM) |
| PT (1) | PT76657B (OSRAM) |
| SU (1) | SU1187718A3 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337418C (en) * | 1988-03-28 | 1995-10-24 | Engelbert Ciganek | 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5086063A (en) * | 1988-03-28 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5019650A (en) * | 1988-03-28 | 1991-05-28 | E. I. Du Pont De Nemours And Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| FR2639226B1 (fr) * | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
| JPH03135978A (ja) * | 1989-08-08 | 1991-06-10 | Merck Sharp & Dohme Ltd | 置換ピリジン、その製法、処方並びに痴呆症における使用法 |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| WO2002046156A2 (en) * | 2000-12-06 | 2002-06-13 | Sepracor, Inc. | 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands |
| ES2268095T3 (es) * | 2001-10-16 | 2007-03-16 | Endo Pharmaceuticals Inc. | Uso de carbinoles para el tratamiento de la disfuncion neuropatica. |
| BR0314821A (pt) * | 2002-11-01 | 2005-08-02 | Neurosearch As | Derivado de piperidina, composição farmacêutica, uso do derivado de piperidina, e, método para tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou uma condição de um corpo animal vivo |
| SE0401465D0 (sv) * | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| AU2005293755A1 (en) * | 2004-10-13 | 2006-04-20 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines |
| EP1802573B1 (en) * | 2004-10-13 | 2016-09-28 | Teva Pharmaceuticals International GmbH | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
| CA2856749A1 (en) | 2011-12-08 | 2013-06-13 | IVAX International GmbH | The hydrobromide salt of pridopidine |
| EP2844346B1 (en) | 2012-04-04 | 2020-01-01 | Prilenia Neurotherapeutics Ltd. | Pharmaceutical compositions for combination therapy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL88235C (OSRAM) * | 1950-12-05 | |||
| FR1049588A (fr) * | 1950-12-05 | 1953-12-30 | Schering Corp | Procédé ?? préparation de pipéridines substituées |
| US2832786A (en) * | 1956-02-27 | 1958-04-29 | Wm S Merrell Co | Phosphoramides |
| AT214445B (de) * | 1957-08-14 | 1961-04-10 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen, substituierten 1-(β-Oxyäthyl)-4-phenylpiperidinen |
| GB841120A (en) * | 1958-02-12 | 1960-07-13 | J F Macfarlan & Co Ltd | Improvements in or relating to piperidine compounds |
| GB888657A (en) * | 1958-07-14 | 1962-01-31 | J F Macfarlan & Co Ltd | Piperidine carbinols |
| US3080372A (en) * | 1960-03-25 | 1963-03-05 | Res Lab Dr C Janssen | 1-aroylalkyl-4-arylpiperidine derivatives |
| US3108211A (en) * | 1960-08-08 | 1963-10-22 | Electro Sonic Ind Inc | Activation of ferroelectric elements |
| GB1243991A (en) * | 1968-06-10 | 1971-08-25 | Ici Ltd | Piperidine, morpholine and piperazine derivatives |
| US3824242A (en) * | 1973-01-26 | 1974-07-16 | Research Corp | Synthesis of meperidine |
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US3998832A (en) * | 1975-04-16 | 1976-12-21 | G. D. Searle & Co. | Anti-diarrheal compounds |
| AU509558B2 (en) * | 1976-10-18 | 1980-05-15 | G. D. Seale & Co | 1-(3, 3, 3-triarylalkyl1) 4-phenyl-piperidinemethanol ethers |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| FR2408602A2 (fr) * | 1977-11-15 | 1979-06-08 | Synthelabo | Nouveaux derives de piperidine et leur methode de preparation |
| US4228288A (en) * | 1978-11-29 | 1980-10-14 | Eli Lilly And Company | Certain substituted 3,4,5,6-tetrahydropyridinium salt intermediates |
| US4284635A (en) * | 1978-11-29 | 1981-08-18 | Eli Lilly And Company | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
| US4277608A (en) * | 1979-06-21 | 1981-07-07 | Eli Lilly And Company | Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines |
| US4236009A (en) * | 1979-06-21 | 1980-11-25 | Eli Lilly And Company | Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines |
-
1983
- 1983-02-25 US US06/468,040 patent/US4485109A/en not_active Expired - Lifetime
- 1983-05-04 GR GR71306A patent/GR77502B/el unknown
- 1983-05-04 DE DE8383104366T patent/DE3375915D1/de not_active Expired
- 1983-05-04 EP EP83104366A patent/EP0094018B1/en not_active Expired
- 1983-05-05 IL IL68586A patent/IL68586A0/xx not_active IP Right Cessation
- 1983-05-05 ES ES522120A patent/ES522120A0/es active Granted
- 1983-05-05 CA CA000427534A patent/CA1252790A/en not_active Expired
- 1983-05-05 PH PH28859A patent/PH18380A/en unknown
- 1983-05-05 NO NO831588A patent/NO162817C/no unknown
- 1983-05-06 FI FI831567A patent/FI78685C/fi not_active IP Right Cessation
- 1983-05-06 SU SU833588607A patent/SU1187718A3/ru active
- 1983-05-06 PT PT76657A patent/PT76657B/pt not_active IP Right Cessation
- 1983-05-06 IE IE1040/83A patent/IE55994B1/en not_active IP Right Cessation
- 1983-05-06 AU AU14311/83A patent/AU560166B2/en not_active Ceased
- 1983-05-06 NZ NZ204150A patent/NZ204150A/en unknown
- 1983-05-06 HU HU831582A patent/HU188278B/hu not_active IP Right Cessation
- 1983-05-06 DK DK205083A patent/DK161699C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE55994B1 (en) | 1991-03-13 |
| DK205083D0 (da) | 1983-05-06 |
| NO162817B (no) | 1989-11-13 |
| AU560166B2 (en) | 1987-04-02 |
| DK161699B (da) | 1991-08-05 |
| DK161699C (da) | 1992-01-13 |
| PT76657B (en) | 1986-04-16 |
| ES8501750A1 (es) | 1984-12-01 |
| ES522120A0 (es) | 1984-12-01 |
| IL68586A0 (en) | 1983-09-30 |
| NZ204150A (en) | 1985-05-31 |
| EP0094018B1 (en) | 1988-03-09 |
| FI78685B (fi) | 1989-05-31 |
| GR77502B (OSRAM) | 1984-09-24 |
| PT76657A (en) | 1983-06-01 |
| IE831040L (en) | 1983-11-07 |
| HU188278B (en) | 1986-03-28 |
| EP0094018A2 (en) | 1983-11-16 |
| NO162817C (no) | 1990-02-21 |
| US4485109A (en) | 1984-11-27 |
| NO831588L (no) | 1983-11-08 |
| DE3375915D1 (de) | 1988-04-14 |
| FI78685C (fi) | 1989-09-11 |
| SU1187718A3 (ru) | 1985-10-23 |
| FI831567A0 (fi) | 1983-05-06 |
| FI831567L (fi) | 1983-11-08 |
| AU1431183A (en) | 1983-11-10 |
| EP0094018A3 (en) | 1985-11-06 |
| DK205083A (da) | 1983-11-08 |
| PH18380A (en) | 1985-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |