CA1234114A - 3,6-disubstituted triazolo¬3,4-a|phthalazine derivatives - Google Patents

3,6-disubstituted triazolo¬3,4-a|phthalazine derivatives

Info

Publication number
CA1234114A
CA1234114A CA000458575A CA458575A CA1234114A CA 1234114 A CA1234114 A CA 1234114A CA 000458575 A CA000458575 A CA 000458575A CA 458575 A CA458575 A CA 458575A CA 1234114 A CA1234114 A CA 1234114A
Authority
CA
Canada
Prior art keywords
formula
alkyl
triazolo
phenyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000458575A
Other languages
English (en)
French (fr)
Inventor
Emilio Occelli
Giorgio Tarzia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA filed Critical Gruppo Lepetit SpA
Application granted granted Critical
Publication of CA1234114A publication Critical patent/CA1234114A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA000458575A 1983-07-12 1984-07-11 3,6-disubstituted triazolo¬3,4-a|phthalazine derivatives Expired CA1234114A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22014A/83 1983-07-12
IT22014/83A IT1194310B (it) 1983-07-12 1983-07-12 Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti

Publications (1)

Publication Number Publication Date
CA1234114A true CA1234114A (en) 1988-03-15

Family

ID=11190206

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000458575A Expired CA1234114A (en) 1983-07-12 1984-07-11 3,6-disubstituted triazolo¬3,4-a|phthalazine derivatives

Country Status (9)

Country Link
US (1) US4783461A (enExample)
EP (1) EP0134946B1 (enExample)
JP (1) JPS6056982A (enExample)
AT (1) ATE28874T1 (enExample)
AU (1) AU560726B2 (enExample)
CA (1) CA1234114A (enExample)
DE (1) DE3465309D1 (enExample)
DK (1) DK164704C (enExample)
IT (1) IT1194310B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0915875B1 (en) 1996-07-25 2003-04-09 MERCK SHARP & DOHME LTD. Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
EP0915877A1 (en) * 1996-07-25 1999-05-19 MERCK SHARP & DOHME LTD. SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE
WO1998050385A1 (en) 1997-05-08 1998-11-12 Merck Sharp & Dohme Limited SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en) * 1998-01-14 2002-05-02 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
MXPA00007135A (es) 1998-01-21 2002-11-07 Merck Sharp & Dohme Derivados de triazolo-piridazina como ligandos para receptores gaba.
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
US6448249B1 (en) 1998-02-25 2002-09-10 Merck Sharp & Dohme Ltd. Substituted 1,2,4-triazolo[3,4-A]phthalazine derivatives as GABAα5 ligands
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
CA2349700A1 (en) 1998-11-12 2000-05-18 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
AU1481701A (en) * 1999-11-12 2001-06-06 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
JP5130053B2 (ja) * 2005-01-05 2013-01-30 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン
MX2007008137A (es) * 2005-01-05 2007-07-19 Altana Pharma Ag Triazoloftalazinas como inhibidores de pde2.
CN102292139B (zh) 2009-01-29 2014-09-03 巴斯夫欧洲公司 用于除去酸性气体的包含氨基酸和酸性促进剂的吸收剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
US3711481A (en) * 1970-04-24 1973-01-16 G Hardtmann 6-aryl-imidazo(2,1-a)phthalazines
US3694442A (en) * 1970-07-28 1972-09-26 William J Houlihan SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO{8 1,2-b{9 PHTHALAZINES
US3704300A (en) * 1971-04-09 1972-11-28 Sandoz Ag Imidazo(2,1-a)phthalazines
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (enExample) * 1979-10-29 1982-09-08 Dow Chemical Co
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4391807A (en) * 1982-07-12 1983-07-05 The Dow Chemical Company 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators
US4485106A (en) * 1982-07-12 1984-11-27 The Dow Chemical Company Substituted tetrahydrotetrazolo[5,1-a]phthalazines
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines

Also Published As

Publication number Publication date
JPS6056982A (ja) 1985-04-02
US4783461A (en) 1988-11-08
DK331884A (da) 1985-01-13
EP0134946A1 (en) 1985-03-27
IT8322014A0 (it) 1983-07-12
AU560726B2 (en) 1987-04-16
DK164704B (da) 1992-08-03
AU3022484A (en) 1985-01-17
DE3465309D1 (de) 1987-09-17
EP0134946B1 (en) 1987-08-12
DK164704C (da) 1992-12-21
DK331884D0 (da) 1984-07-06
IT1194310B (it) 1988-09-14
JPH051267B2 (enExample) 1993-01-07
ATE28874T1 (de) 1987-08-15

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