ATE28874T1 - 3,6-disubstituierte triazolo(3,4a>phthalazinderivate. - Google Patents
3,6-disubstituierte triazolo(3,4a>phthalazinderivate.Info
- Publication number
- ATE28874T1 ATE28874T1 AT84107562T AT84107562T ATE28874T1 AT E28874 T1 ATE28874 T1 AT E28874T1 AT 84107562 T AT84107562 T AT 84107562T AT 84107562 T AT84107562 T AT 84107562T AT E28874 T1 ATE28874 T1 AT E28874T1
- Authority
- AT
- Austria
- Prior art keywords
- triazolo
- disubstituted
- formula
- phthalazine derivatives
- alkoxy
- Prior art date
Links
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 3,6-disubstituted-1,2,4-triazolo[3,4-a]phthalazine Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22014/83A IT1194310B (it) | 1983-07-12 | 1983-07-12 | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| EP84107562A EP0134946B1 (en) | 1983-07-12 | 1984-06-29 | 3,6-Disubstituted-triazolo[3,4-a]phthalazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE28874T1 true ATE28874T1 (de) | 1987-08-15 |
Family
ID=11190206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84107562T ATE28874T1 (de) | 1983-07-12 | 1984-06-29 | 3,6-disubstituierte triazolo(3,4a>phthalazinderivate. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4783461A (enExample) |
| EP (1) | EP0134946B1 (enExample) |
| JP (1) | JPS6056982A (enExample) |
| AT (1) | ATE28874T1 (enExample) |
| AU (1) | AU560726B2 (enExample) |
| CA (1) | CA1234114A (enExample) |
| DE (1) | DE3465309D1 (enExample) |
| DK (1) | DK164704C (enExample) |
| IT (1) | IT1194310B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU724076B2 (en) * | 1996-07-25 | 2000-09-14 | Merck Sharp & Dohme Limited | Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAalpha5 receptor subtype |
| IL127911A0 (en) | 1996-07-25 | 1999-11-30 | Merck Sharp & Dohme | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
| DE69807074T2 (de) | 1997-05-08 | 2003-04-03 | Merck Sharp & Dohme Ltd., Hoddesdon | Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden |
| GB9715977D0 (en) | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9723999D0 (en) | 1997-11-13 | 1998-01-14 | Merck Sharp & Dohme | Therapeutic use |
| GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9726699D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9726701D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| US6110915A (en) * | 1997-12-18 | 2000-08-29 | Merck & Co., Inc. | Antiemetic use of triazolo-pyridazine derivatives |
| EP1047697A1 (en) | 1998-01-14 | 2000-11-02 | MERCK SHARP & DOHME LTD. | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| MXPA00007135A (es) * | 1998-01-21 | 2002-11-07 | Merck Sharp & Dohme | Derivados de triazolo-piridazina como ligandos para receptores gaba. |
| GB9801208D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801202D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801234D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801210D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801397D0 (en) | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801538D0 (en) | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
| YU46500A (sh) | 1998-02-25 | 2002-11-15 | Merck Charp & Dohme Limited | Substituisani 1,2,4-triazolo /3,4-a/piridazin |
| IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| GB9824897D0 (en) | 1998-11-12 | 1999-01-06 | Merck Sharp & Dohme | Therapeutic compounds |
| EP1129094A2 (en) | 1998-11-12 | 2001-09-05 | Merck & Co., Inc. | Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same |
| WO2001034603A2 (en) * | 1999-11-12 | 2001-05-17 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
| GB0028583D0 (en) | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
| CN101103033B (zh) * | 2005-01-05 | 2010-08-04 | 尼科梅德有限责任公司 | 作为pde2抑制剂的三唑并酞嗪 |
| EP1874775B1 (en) * | 2005-01-05 | 2012-10-10 | Nycomed GmbH | Triazolophthalazines as pde2-inhibitors |
| ES2428236T3 (es) | 2009-01-29 | 2013-11-06 | Basf Se | Agente absorbente que contiene aminoácido y promotor ácido para la eliminación de gases ácidos |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2484029A (en) * | 1945-12-21 | 1949-10-11 | Ciba Pharm Prod Inc | Hydrazine derivatives of pyridazine compounds |
| GB629177A (en) * | 1945-12-21 | 1949-09-14 | Ciba Ltd | Manufacture of new hydrazine compounds and derivatives thereof |
| US3711481A (en) * | 1970-04-24 | 1973-01-16 | G Hardtmann | 6-aryl-imidazo(2,1-a)phthalazines |
| US3694442A (en) * | 1970-07-28 | 1972-09-26 | William J Houlihan | SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO{8 1,2-b{9 PHTHALAZINES |
| US3704300A (en) * | 1971-04-09 | 1972-11-28 | Sandoz Ag | Imidazo(2,1-a)phthalazines |
| JPS603080B2 (ja) * | 1976-08-10 | 1985-01-25 | 三菱化学株式会社 | Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類 |
| GR70309B (enExample) * | 1979-10-29 | 1982-09-08 | Dow Chemical Co | |
| PH21834A (en) * | 1982-01-18 | 1988-03-17 | Lepetit Spa | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives |
| US4485106A (en) * | 1982-07-12 | 1984-11-27 | The Dow Chemical Company | Substituted tetrahydrotetrazolo[5,1-a]phthalazines |
| US4391807A (en) * | 1982-07-12 | 1983-07-05 | The Dow Chemical Company | 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators |
| US4487930A (en) * | 1982-09-07 | 1984-12-11 | The Dow Chemical Company | 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines |
-
1983
- 1983-07-12 IT IT22014/83A patent/IT1194310B/it active
-
1984
- 1984-06-29 EP EP84107562A patent/EP0134946B1/en not_active Expired
- 1984-06-29 AT AT84107562T patent/ATE28874T1/de not_active IP Right Cessation
- 1984-06-29 DE DE8484107562T patent/DE3465309D1/de not_active Expired
- 1984-07-03 AU AU30224/84A patent/AU560726B2/en not_active Ceased
- 1984-07-06 DK DK331884A patent/DK164704C/da not_active IP Right Cessation
- 1984-07-10 JP JP59141573A patent/JPS6056982A/ja active Granted
- 1984-07-11 US US06/629,658 patent/US4783461A/en not_active Expired - Fee Related
- 1984-07-11 CA CA000458575A patent/CA1234114A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT1194310B (it) | 1988-09-14 |
| JPS6056982A (ja) | 1985-04-02 |
| DK331884A (da) | 1985-01-13 |
| EP0134946B1 (en) | 1987-08-12 |
| IT8322014A0 (it) | 1983-07-12 |
| AU3022484A (en) | 1985-01-17 |
| DE3465309D1 (de) | 1987-09-17 |
| DK164704C (da) | 1992-12-21 |
| CA1234114A (en) | 1988-03-15 |
| DK164704B (da) | 1992-08-03 |
| JPH051267B2 (enExample) | 1993-01-07 |
| AU560726B2 (en) | 1987-04-16 |
| DK331884D0 (da) | 1984-07-06 |
| US4783461A (en) | 1988-11-08 |
| EP0134946A1 (en) | 1985-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |