CA1202616A - Sulfonate containing ester prodrugs of corticosteroids - Google Patents

Sulfonate containing ester prodrugs of corticosteroids

Info

Publication number
CA1202616A
CA1202616A CA000447557A CA447557A CA1202616A CA 1202616 A CA1202616 A CA 1202616A CA 000447557 A CA000447557 A CA 000447557A CA 447557 A CA447557 A CA 447557A CA 1202616 A CA1202616 A CA 1202616A
Authority
CA
Canada
Prior art keywords
general formula
compound
formula
compounds
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000447557A
Other languages
English (en)
French (fr)
Inventor
Bradley D. Anderson
Robert A. Conradi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of CA1202616A publication Critical patent/CA1202616A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA000447557A 1983-03-30 1984-02-15 Sulfonate containing ester prodrugs of corticosteroids Expired CA1202616A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US480,603 1983-03-30
US06/480,603 US4469689A (en) 1983-03-30 1983-03-30 Sulfonate containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
CA1202616A true CA1202616A (en) 1986-04-01

Family

ID=23908597

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000447557A Expired CA1202616A (en) 1983-03-30 1984-02-15 Sulfonate containing ester prodrugs of corticosteroids

Country Status (6)

Country Link
US (1) US4469689A (en:Method)
EP (1) EP0124233B1 (en:Method)
JP (1) JPS59191000A (en:Method)
CA (1) CA1202616A (en:Method)
DE (1) DE3479891D1 (en:Method)
ZA (1) ZA841455B (en:Method)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
WO1987002672A1 (en) * 1985-10-23 1987-05-07 The Upjohn Company Tetrahydro angiostatic steroids
US5250711A (en) * 1987-07-16 1993-10-05 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides
DE3877361T2 (de) * 1987-07-16 1993-05-13 Upjohn Co Aminosalze von alkan-1,n-dicarbonsaeure-mono-(2-sulfato-aethyl)amiden.
WO1994015947A1 (en) * 1993-01-08 1994-07-21 Astra Aktiebolag Novel colon- or ileum-specific steroid derivatives
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
CA2395119A1 (en) * 1999-12-21 2001-06-21 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of carboxy compounds such as 2(4-acetoxyphenyl)-2-chloro-n-methyl-ethylammonium chloride as anti-inflammatory agents
KR100472303B1 (ko) * 2002-05-21 2005-03-08 김영미 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체
US20040157810A1 (en) * 2002-08-23 2004-08-12 Teicher Martin H. Corticosteroid conjugates and uses thereof
CN101970042A (zh) 2008-02-25 2011-02-09 眼门药品公司 经由离子电渗法增强递送治疗药物至眼部组织
US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
JP2012516900A (ja) * 2009-02-05 2012-07-26 トーカイ ファーマシューティカルズ，インク． ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ
WO2013074988A1 (en) * 2011-11-17 2013-05-23 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations
CA2873771A1 (en) 2012-05-21 2013-11-28 The Regents Of The University Of Colorado, A Body Corporate Ledgf peptides and formulations thereof for treatment of degenerative disorders
EP2968370A4 (en) 2013-03-14 2016-09-21 Univ Maryland AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF
BR112016002970A2 (pt) 2013-08-12 2017-09-12 Tokai Pharmaceuticals Inc biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio
CA3075895A1 (en) * 2017-10-02 2019-04-11 Scientist Of Fortune S.A. Cellular transport system for transferring a sulfonic acid construct carrying a cargo into the cytoplasm of a cell

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
FR2408622A1 (fr) * 1977-05-06 1979-06-08 Roussel Uclaf Nouveaux derives du pregn 4-ene, leur procede de preparation et leur application comme medicament
DK404879A (da) * 1978-10-04 1980-04-05 Schering Ag Kortikoid-21-sulfopropionater og deres salte fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende disse forbindelser

Also Published As

Publication number Publication date
EP0124233B1 (en) 1989-09-27
ZA841455B (en) 1984-10-31
EP0124233A2 (en) 1984-11-07
JPS59191000A (ja) 1984-10-29
EP0124233A3 (en) 1985-01-16
JPH041760B2 (en:Method) 1992-01-14
US4469689A (en) 1984-09-04
DE3479891D1 (en) 1989-11-02

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Legal Events

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