CA1199579A - Process for the purification of physiologically active substance having antitumor activity - Google Patents

Process for the purification of physiologically active substance having antitumor activity

Info

Publication number
CA1199579A
CA1199579A CA000405748A CA405748A CA1199579A CA 1199579 A CA1199579 A CA 1199579A CA 000405748 A CA000405748 A CA 000405748A CA 405748 A CA405748 A CA 405748A CA 1199579 A CA1199579 A CA 1199579A
Authority
CA
Canada
Prior art keywords
active substance
substance
physiologically active
rabbit
subjecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000405748A
Other languages
English (en)
French (fr)
Inventor
Katsuyuki Haranaka
Lloyd J. Old
Elizabeth C. Richards
Barbara Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP56209840A priority Critical patent/JPS57140725A/ja
Priority to EP82301853A priority patent/EP0090892B1/en
Priority to AT82301853T priority patent/ATE23540T1/de
Priority to FR8206351A priority patent/FR2524891B1/fr
Priority to BE0/207819A priority patent/BE892846A/fr
Application filed by Dainippon Pharmaceutical Co Ltd, Asahi Kasei Kogyo KK filed Critical Dainippon Pharmaceutical Co Ltd
Priority to CA000405748A priority patent/CA1199579A/en
Application granted granted Critical
Publication of CA1199579A publication Critical patent/CA1199579A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compounds Of Unknown Constitution (AREA)
CA000405748A 1981-12-28 1982-06-22 Process for the purification of physiologically active substance having antitumor activity Expired CA1199579A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP56209840A JPS57140725A (en) 1981-12-28 1981-12-28 Physiologically active substance having carcinostatic action
EP82301853A EP0090892B1 (en) 1981-12-28 1982-04-07 Process for the purification of physiologically active substance having antitumour activity
AT82301853T ATE23540T1 (de) 1981-12-28 1982-04-07 Verfahren zur reinigung einer physiologisch aktiven substanz mit antitumor aktivitaet.
FR8206351A FR2524891B1 (fr) 1981-12-28 1982-04-13 Procede pour purifier une substance proteinee douee d'activite antitumorale
BE0/207819A BE892846A (fr) 1981-12-28 1982-04-14 Procede de purification de substance physiologiquement active a activite antitumorale, et substance ainsi obtenue
CA000405748A CA1199579A (en) 1981-12-28 1982-06-22 Process for the purification of physiologically active substance having antitumor activity

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP56209840A JPS57140725A (en) 1981-12-28 1981-12-28 Physiologically active substance having carcinostatic action
EP82301853A EP0090892B1 (en) 1981-12-28 1982-04-07 Process for the purification of physiologically active substance having antitumour activity
FR8206351A FR2524891B1 (fr) 1981-12-28 1982-04-13 Procede pour purifier une substance proteinee douee d'activite antitumorale
BE0/207819A BE892846A (fr) 1981-12-28 1982-04-14 Procede de purification de substance physiologiquement active a activite antitumorale, et substance ainsi obtenue
CA000405748A CA1199579A (en) 1981-12-28 1982-06-22 Process for the purification of physiologically active substance having antitumor activity

Publications (1)

Publication Number Publication Date
CA1199579A true CA1199579A (en) 1986-01-21

Family

ID=27507588

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000405748A Expired CA1199579A (en) 1981-12-28 1982-06-22 Process for the purification of physiologically active substance having antitumor activity

Country Status (6)

Country Link
EP (1) EP0090892B1 (https=)
JP (1) JPS57140725A (https=)
AT (1) ATE23540T1 (https=)
BE (1) BE892846A (https=)
CA (1) CA1199579A (https=)
FR (1) FR2524891B1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140725A (en) * 1981-12-28 1982-08-31 Dainippon Pharmaceut Co Ltd Physiologically active substance having carcinostatic action
US4920196A (en) * 1982-07-30 1990-04-24 Genentech, Inc. Human lymphotoxin
AU8956582A (en) * 1982-10-06 1984-04-24 Makitsubo, T. Process for extracting tumor necrosis factor from macrophage
JPS59118716A (ja) * 1982-12-24 1984-07-09 Otsuka Pharmaceut Co Ltd 制ガン作用を有する低分子蛋白質
JPS6019719A (ja) 1983-07-15 1985-01-31 Asahi Chem Ind Co Ltd 抗腫瘍活性を有する蛋白質
GB8330969D0 (en) * 1983-11-21 1983-12-29 Wellcome Found Promoting healing
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
GB2161813B (en) * 1984-07-20 1988-07-13 Michiko Koga Anti-tumor agent
EP0178050A1 (en) * 1984-08-13 1986-04-16 The Wellcome Foundation Limited Proteinaceous substance
JPS6163698A (ja) * 1984-09-05 1986-04-01 Asahi Chem Ind Co Ltd 生理活性物質に対するモノクロ−ナル抗体とそれを用いる生理活性物質の精製方法
US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
JPH0688906B2 (ja) * 1988-08-10 1994-11-09 株式会社生体調節研究所 制癌作用を有する生物活性物質の製造方法およびそれにより得られる制癌作用を有する生物活性物質
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140725A (en) * 1981-12-28 1982-08-31 Dainippon Pharmaceut Co Ltd Physiologically active substance having carcinostatic action

Also Published As

Publication number Publication date
ATE23540T1 (de) 1986-11-15
FR2524891A1 (fr) 1983-10-14
BE892846A (fr) 1982-10-14
EP0090892A1 (en) 1983-10-12
FR2524891B1 (fr) 1988-01-08
EP0090892B1 (en) 1986-11-12
JPS57140725A (en) 1982-08-31
JPS6363558B2 (https=) 1988-12-07

Similar Documents

Publication Publication Date Title
CA1199579A (en) Process for the purification of physiologically active substance having antitumor activity
EP0132125B2 (en) A protein having antitumor activity
US4845078A (en) Method for treating hematopoietic diseases
JP3713277B2 (ja) 精製方法
US5023320A (en) Process for the purification of physiologically active substance having antitumor activity
KR890004692B1 (ko) 항종양 생리학적 활성물질의 정제방법
CA1207262A (en) Human leucocyte pepsin-like enzyme, method for preparation of the enzyme, and method and therapeutic agent for treating allergic disorders, immune complex diseases and tumors containing the same as an effective ingredient
JPS6019720A (ja) ヒト内来性癌制御因子およびその製造法
EP0100366A1 (en) Agent for treating allergic disease, immunity complex disease, and tumour
EP0134247A1 (en) Protein with oncostatic effect, process for its preparation, and oncostatic drug containing it
JPH064675B2 (ja) 抗腫瘍性ポリペプチド
JPS60226816A (ja) 抗腫瘍活性をもつヒト由来蛋白質
EP0085556B1 (en) A method of fractional collection of gastric acid secretion inhibiting components
JPS6363559B2 (https=)
US4676983A (en) Tumor cytostatic-citocidal factor from blood platelets
NO850152L (no) Fremgangsmaate ved fremstilling av human, endogen cancerregulerende faktor.
JPS608226A (ja) 低分子蛋白質を有効成分とする制ガン剤
DK158230B (da) Fremgangsmaade til rensning af et proteinlignende fysiologisk aktivt stof med antitumorvirkning og det proteinlignende fysiologisk aktive stof, der er renset ved denne fremgangsmaade
JPS6137730A (ja) 制ガン作用を有する蛋白質
JPH0259840B2 (https=)
JPS5982315A (ja) 腫瘍壊死因子の製造法
JPS59118714A (ja) 制ガン作用を有する低分子蛋白質
CH656623A5 (en) Process for the purification of a protein-containing, physiologically active substance with antitumour action
JPS60139624A (ja) 抗腫瘍作用を有する蛋白質
JPH0665296A (ja) 免疫賦活物質およびその分画方法

Legal Events

Date Code Title Description
MKEX Expiry