CA1170597A - Method for cultivating microorganisms, particularly yeasts, on lactoserum with an association of judiciously selected strains and of specific mutants of a strain - Google Patents
Method for cultivating microorganisms, particularly yeasts, on lactoserum with an association of judiciously selected strains and of specific mutants of a strainInfo
- Publication number
- CA1170597A CA1170597A CA000388215A CA388215A CA1170597A CA 1170597 A CA1170597 A CA 1170597A CA 000388215 A CA000388215 A CA 000388215A CA 388215 A CA388215 A CA 388215A CA 1170597 A CA1170597 A CA 1170597A
- Authority
- CA
- Canada
- Prior art keywords
- strains
- lactoserum
- substrate
- association
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 30
- 240000004808 Saccharomyces cerevisiae Species 0.000 title claims abstract description 11
- 244000005700 microbiome Species 0.000 title claims abstract description 9
- 239000000758 substrate Substances 0.000 claims abstract description 35
- 239000002207 metabolite Substances 0.000 claims abstract description 11
- 238000000855 fermentation Methods 0.000 claims abstract description 10
- 230000004151 fermentation Effects 0.000 claims abstract description 10
- 241000894007 species Species 0.000 claims abstract description 10
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 5
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 5
- 238000000926 separation method Methods 0.000 claims abstract description 5
- 238000011084 recovery Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 28
- 239000008101 lactose Substances 0.000 claims description 20
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 19
- 239000002609 medium Substances 0.000 claims description 15
- 235000014655 lactic acid Nutrition 0.000 claims description 14
- 239000004310 lactic acid Substances 0.000 claims description 14
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 239000008103 glucose Substances 0.000 claims description 7
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims description 6
- 241001138401 Kluyveromyces lactis Species 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 241000235646 Cyberlindnera jadinii Species 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 229930182830 galactose Natural products 0.000 claims description 5
- 238000000108 ultra-filtration Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 4
- 235000013351 cheese Nutrition 0.000 claims description 4
- 239000001963 growth medium Substances 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 241000235070 Saccharomyces Species 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 238000004255 ion exchange chromatography Methods 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 230000007717 exclusion Effects 0.000 claims description 2
- 238000002270 exclusion chromatography Methods 0.000 claims description 2
- 241000235650 Kluyveromyces marxianus Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 239000002028 Biomass Substances 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 9
- 229910052799 carbon Inorganic materials 0.000 description 9
- 229960004756 ethanol Drugs 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 9
- 244000285963 Kluyveromyces fragilis Species 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 102000011632 Caseins Human genes 0.000 description 3
- 108010076119 Caseins Proteins 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
- 235000021240 caseins Nutrition 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- FBEHFRAORPEGFH-UHFFFAOYSA-N Allyxycarb Chemical class CNC(=O)OC1=CC(C)=C(N(CC=C)CC=C)C(C)=C1 FBEHFRAORPEGFH-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000235649 Kluyveromyces Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 229940108461 rennet Drugs 0.000 description 2
- 108010058314 rennet Proteins 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 240000002129 Malva sylvestris Species 0.000 description 1
- 235000006770 Malva sylvestris Nutrition 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940021722 caseins Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229940070376 protein Drugs 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P39/00—Processes involving microorganisms of different genera in the same process, simultaneously
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/32—Processes using, or culture media containing, lower alkanols, i.e. C1 to C6
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR80/22401 | 1980-10-20 | ||
| FR8022401A FR2492403A1 (fr) | 1980-10-20 | 1980-10-20 | Procede de culture de microorganismes, en particulier de levures, sur du lactoserum avec une association de souches judicieusement choisies et des mutants specifiques d'une souche |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1170597A true CA1170597A (en) | 1984-07-10 |
Family
ID=9247095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000388215A Expired CA1170597A (en) | 1980-10-20 | 1981-10-19 | Method for cultivating microorganisms, particularly yeasts, on lactoserum with an association of judiciously selected strains and of specific mutants of a strain |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0050571B1 (enrdf_load_stackoverflow) |
| AT (1) | ATE6271T1 (enrdf_load_stackoverflow) |
| CA (1) | CA1170597A (enrdf_load_stackoverflow) |
| DE (1) | DE3162319D1 (enrdf_load_stackoverflow) |
| FR (1) | FR2492403A1 (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486368A (en) * | 1992-05-28 | 1996-01-23 | Dmv Usa, Inc. | Production of a cultured yeast product from whey permeate, yeast cream and yeast centrate |
| CN101200733B (zh) * | 2007-12-11 | 2010-12-08 | 天津科技大学 | 酵母菌混合发酵乳清生产燃料乙醇的方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595659A (en) * | 1983-10-20 | 1986-06-17 | Kraft, Inc. | Fermentation production of ascorbic acid from L-galactonic substrate |
| DD272182A3 (de) * | 1986-12-17 | 1989-10-04 | Leipzig Chemieanlagen | Verfahren zur gewinnung von hochwertigem futtereiweiss aus molke |
| DE4447352C2 (de) * | 1994-12-20 | 1998-09-17 | Steripharm Pharmazeutische Pro | Verfahren zur Herstellung Galactose enthaltender Zubereitungen für die enterale und parenterale Ernährung von Patienten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH233548A (de) * | 1941-11-29 | 1944-08-15 | Ig Farbenindustrie Ag | Verfahren zur Gewinnung von Hefe aus kohlehydrathaltigen Lösungen. |
| FR1002238A (fr) * | 1946-08-22 | 1952-03-04 | Procédé pour la fabrication directe d'extraits de levures | |
| FR1128063A (fr) * | 1955-06-22 | 1957-01-02 | Bel La Vache Qui Rit Fromage | Procédé de fabrication de levures alimentaires lactiques |
| US3818109A (en) * | 1971-03-19 | 1974-06-18 | Univ Kansas State | Conversion of whey solids to an edible yeast cell mass |
| GB1528011A (en) * | 1975-02-11 | 1978-10-11 | Shell Int Research | Continuous culture of micro-organisms |
| FR2439819A1 (fr) * | 1978-10-24 | 1980-05-23 | Bel Fromageries | Perfectionnements a la fabrication de levures lactiques |
-
1980
- 1980-10-20 FR FR8022401A patent/FR2492403A1/fr active Granted
-
1981
- 1981-10-19 EP EP81401640A patent/EP0050571B1/fr not_active Expired
- 1981-10-19 AT AT81401640T patent/ATE6271T1/de not_active IP Right Cessation
- 1981-10-19 DE DE8181401640T patent/DE3162319D1/de not_active Expired
- 1981-10-19 CA CA000388215A patent/CA1170597A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486368A (en) * | 1992-05-28 | 1996-01-23 | Dmv Usa, Inc. | Production of a cultured yeast product from whey permeate, yeast cream and yeast centrate |
| CN101200733B (zh) * | 2007-12-11 | 2010-12-08 | 天津科技大学 | 酵母菌混合发酵乳清生产燃料乙醇的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0050571B1 (fr) | 1984-02-15 |
| FR2492403A1 (fr) | 1982-04-23 |
| FR2492403B1 (enrdf_load_stackoverflow) | 1983-09-23 |
| DE3162319D1 (en) | 1984-03-22 |
| EP0050571A1 (fr) | 1982-04-28 |
| ATE6271T1 (de) | 1984-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |